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Mast2 Gene Detail
Summary
  • Symbol
    Mast2
  • Name
    microtubule associated serine/threonine kinase 2
  • Synonyms
    MAST205, mKIAA0807, Mtssk
  • Feature Type
    protein coding gene
  • IDs
    MGI:894676
    NCBI Gene: 17776
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116163957-116321420 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.10 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5919 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894676
 protein coding gene Chr4:116163957-116321471 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028624
 protein coding gene Chr4:117179650-117347244 (-)
A/J MGP_AJ_G0028585
 protein coding gene Chr4:112706200-112866334 (-)
AKR/J MGP_AKRJ_G0028535
 protein coding gene Chr4:115128580-115293929 (-)
BALB/cJ MGP_BALBcJ_G0028606
 protein coding gene Chr4:113333162-113493133 (-)
C3H/HeJ MGP_C3HHeJ_G0028320
 protein coding gene Chr4:116701044-116861368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029047
 protein coding gene Chr4:121727195-121901192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026331
 protein coding gene Chr4:106748352-106904986 (-)
CAST/EiJ MGP_CASTEiJ_G0027754
 protein coding gene Chr4:113929944-114095297 (-)
CBA/J MGP_CBAJ_G0028287
 protein coding gene Chr4:125040354-125202985 (-)
DBA/2J MGP_DBA2J_G0028435
 protein coding gene Chr4:113342416-113499166 (-)
FVB/NJ MGP_FVBNJ_G0028403
 protein coding gene Chr4:111841887-111998592 (-)
LP/J MGP_LPJ_G0028537
 protein coding gene Chr4:117387454-117554774 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028430
 protein coding gene Chr4:130028705-130198743 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029084
 protein coding gene Chr4:116285079-116445170 (-)
PWK/PhJ MGP_PWKPhJ_G0027480
 protein coding gene Chr4:110116314-110275682 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027303
 protein coding gene Chr4:112551969-112722341 (-)
WSB/EiJ MGP_WSBEiJ_G0027833
 protein coding gene Chr4:116157759-116325448 (-)



Homology
more
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
  • Synonyms
    MAST205, MTSSK
  • Links
    NCBI Gene ID: 23139
    UniProt: Q6P0Q8

  • Chr Location
    1p34.1; chr1:45786987-46036122 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
No phenotype has been reported for a gene trap strain; however, it is not yet known whether the gene trap insertion affects expression of the gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    54
  • cDNA Data
    205
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17776 NCBI Gene Model | MGI Sequence Detail 157464 C57BL/6J ±  kb
    transcript NM_001369061 RefSeq | MGI Sequence Detail 5766 C57BL/6  
    polypeptide Q60592 UniProt | EBI | MGI Sequence Detail 1734 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000010196 microtubule-associated serine/threonine-protein kinase 2
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR000961 AGC-kinase, C-terminal
      IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
      IPR015022 Microtubule-associated serine/threonine-protein kinase, pre-PK domain
      IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
      IPR051067 Na+/H+ exchange regulatory cofactor
      IPR001478 PDZ domain
      IPR041489 PDZ domain 6
      IPR036034 PDZ superfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR050236 Serine/threonine-protein kinases, AGC
    • GlyGen
      Q60592 2 sites
    Molecular
    Reagents
    less
    • All nucleic 207
      cDNA 206
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:41184 Walden PD, et al., A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Mol Cell Biol. 1993 Dec;13(12):7625-35
    • Latest
      J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory