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Mast2 Gene Detail
Summary
  • Symbol
    Mast2
  • Name
    microtubule associated serine/threonine kinase 2
  • Synonyms
    MAST205, mKIAA0807, Mtssk
  • Feature Type
    protein coding gene
  • IDs
    MGI:894676
    NCBI Gene: 17776
  • Gene Overview
    MyGene.info: MAST2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:116306762-116463922 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      157161 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.10 cM, cytoband C7
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAST205, MTSSK
  • Links
    NCBI Gene ID: 23139
    neXtProt AC: NX_Q6P0Q8
    UniProt: Q6P0Q8

  • Chr Location
    1p34.1; chr1:45786992-46036124 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7428
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MAST2
  • Gene Tree
    Mast2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
No phenotype has been reported for a gene trap strain; however, it is not yet known whether the gene trap insertion affects expression of the gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    60
  • Tissues
    53
  • cDNA Data
    205
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009403 VEGA Gene Model | MGI Sequence Detail 157161 C57BL/6J ±  kb
    transcript OTTMUST00000021417 VEGA | MGI Sequence Detail 5292 Not Applicable  
    polypeptide OTTMUSP00000009793 VEGA | MGI Sequence Detail 1739 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      288 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR000961 AGC-kinase, C-terminal
      IPR028779 Microtubule-associated serine/threonine-protein kinase 2
      IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
      IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
      IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 207
      cDNA 206
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:41184 Walden PD, et al., A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Mol Cell Biol. 1993 Dec;13(12):7625-35
    • Latest
      J:236302 Zhang X, et al., Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory