Mast2 MGI Mouse Gene Detail - MGI:894676 - microtubule associated serine/threonine kinase 2

Symbol

Mast2
Name

microtubule associated serine/threonine kinase 2
Synonyms

MAST205, mKIAA0807, Mtssk

Feature Type

protein coding gene
IDs

MGI:894676
NCBI Gene: 17776
Gene Overview

MyGene.info: MAST2
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:116306762-116464183 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.10 cM, cytoband C7
Mapping Data

2 experiments

SNPs within 2kb

288 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894676	protein coding gene	Chr4:116306760-116464223 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028624	protein coding gene	Chr4:117179650-117347244 (-)
A/J	MGP_AJ_G0028585	protein coding gene	Chr4:112706200-112866334 (-)
AKR/J	MGP_AKRJ_G0028535	protein coding gene	Chr4:115128580-115293929 (-)
BALB/cJ	MGP_BALBcJ_G0028606	protein coding gene	Chr4:113333162-113493133 (-)
C3H/HeJ	MGP_C3HHeJ_G0028320	protein coding gene	Chr4:116701044-116861368 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029047	protein coding gene	Chr4:121727195-121901192 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026331	protein coding gene	Chr4:106748352-106904986 (-)
CAST/EiJ	MGP_CASTEiJ_G0027754	protein coding gene	Chr4:113929944-114095297 (-)
CBA/J	MGP_CBAJ_G0028287	protein coding gene	Chr4:125040354-125202985 (-)
DBA/2J	MGP_DBA2J_G0028435	protein coding gene	Chr4:113342416-113499166 (-)
FVB/NJ	MGP_FVBNJ_G0028403	protein coding gene	Chr4:111841887-111998592 (-)
LP/J	MGP_LPJ_G0028537	protein coding gene	Chr4:117387454-117554774 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028430	protein coding gene	Chr4:130028705-130198743 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029084	protein coding gene	Chr4:116285079-116445170 (-)
PWK/PhJ	MGP_PWKPhJ_G0027480	protein coding gene	Chr4:110116314-110275682 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027303	protein coding gene	Chr4:112551969-112722341 (-)
WSB/EiJ	MGP_WSBEiJ_G0027833	protein coding gene	Chr4:116157759-116325448 (-)

Human Ortholog

MAST2, microtubule associated serine/threonine kinase 2

Vertebrate Orthologs

10

Human Ortholog

MAST2, microtubule associated serine/threonine kinase 2
Orthology source: HomoloGene, HGNC
Synonyms

MAST205, MTSSK
Links

HGNC:19035

NCBI Gene ID: 23139

neXtProt AC: NX_Q6P0Q8

UniProt: Q6P0Q8
Chr Location

1p34.1; chr1:45786992-46036124 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7428
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MAST2
Gene Tree

Mast2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

2
Gene trapped

13
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Mast2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

No phenotype has been reported for a gene trap strain; however, it is not yet known whether the gene trap insertion affects expression of the gene.

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All GO Annotations

27
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

53
cDNA Data

205
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mast2

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Mast2 interacts with 50 markers (Mir1a-1, Mir1a-2, Mir19a, ...) View All

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All Sequences

114
RefSeq

40
UniProt

10
CCDS

CCDS38849.1, CCDS38850.1
UniGene

9287

Ensembl

ENSMUSG00000003810 (Evidence)
NCBI Gene

17776

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003810	Ensembl Gene Model \| MGI Sequence Detail	157422	C57BL/6J	± kb
transcript	ENSMUST00000106486	Ensembl \| MGI Sequence Detail	5723	Not Applicable
polypeptide	ENSMUSP00000102095	Ensembl \| MGI Sequence Detail	1800	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010196 microtubule-associated serine/threonine-protein kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR028779 Microtubule-associated serine/threonine-protein kinase 2

IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain

IPR015022 Microtubule-associated serine/threonine-protein kinase, domain

IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily

IPR001478 PDZ domain

IPR041489 PDZ domain 6

IPR036034 PDZ superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 207

cDNA 206

Primer pair 1

Microarray probesets 3

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 17
Earliest

J:41184 Walden PD, et al., A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Mol Cell Biol. 1993 Dec;13(12):7625-35
Latest

J:268904 Tripathy R, et al., Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations. Neuron. 2018 Dec 19;100(6):1354-1368.e5

TSS for Mast2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42882	Chr4:116464151-116464274 (-)	-30 bp
Tssr42881	Chr4:116406845-116406861 (-)	57,330 bp
Tssr42880	Chr4:116406134-116406238 (-)	57,997 bp
Tssr42879	Chr4:116406108-116406120 (-)	58,069 bp
Tssr42877	Chr4:116371801-116371818 (-)	92,373 bp
Tssr42876	Chr4:116371769-116371783 (-)	92,407 bp
Tssr42875	Chr4:116371748-116371759 (-)	92,429 bp
Tssr42874	Chr4:116371724-116371743 (-)	92,449 bp
Tssr42873	Chr4:116371659-116371663 (-)	92,522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16