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Mast2 Gene Detail
Summary
  • Symbol
    Mast2
  • Name
    microtubule associated serine/threonine kinase 2
  • Synonyms
    MAST205, mKIAA0807, Mtssk
  • Feature Type
    protein coding gene
  • IDs
    MGI:894676
    NCBI Gene: 17776
  • Gene Overview
    MyGene.info: MAST2
Location & Maps
more
  • Sequence Map
    Chr4:116306762-116463922 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      157161 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.10 cM, cytoband C7
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAST2, microtubule associated serine/threonine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAST205, MTSSK
  • Links
    NCBI Gene ID: 23139
    neXtProt AC: NX_Q6P0Q8

  • Chr Location
    1p34.1; chr1:45786992-46036124 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 7428
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MAST2
  • Gene Tree
    Mast2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Mast2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
No phenotype has been reported for a gene trap strain; however, it is not yet known whether the gene trap insertion affects expression of the gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    60
  • Tissues
    53
  • cDNA Data
    204
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009403 VEGA Gene Model | MGI Sequence Detail 157161 C57BL/6J ±  kb
transcript OTTMUST00000021417 VEGA | MGI Sequence Detail 5292 Not Applicable  
polypeptide OTTMUSP00000009793 VEGA | MGI Sequence Detail 1739 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    288 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000010196 microtubule-associated serine/threonine-protein kinase 2
  • EC
    2.7.11.1
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR028779 Microtubule-associated serine/threonine-protein kinase 2
    IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
    IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain
    IPR001478 PDZ domain
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 206
    cDNA 205
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:41184 Walden PD, et al., A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Mol Cell Biol. 1993 Dec;13(12):7625-35
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory