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Tnfrsf18
Gene Detail
Symbol

Name
ID
Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
MGI:894675
Synonyms
Gitr
Feature Type
protein coding gene
Genetic Map
Chromosome 4
87.76 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:156026164-156028895 bp, + strand
From VEGA annotation of GRCm38

  2732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48270  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TNFRSF18
Gene Tree: Tnfrsf18

Human
homologs
TNFRSF18, tumor necrosis factor receptor superfamily, member 18
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8784
neXtProt AC: NX_Q9Y5U5

Human Synonyms: AITR, CD357, GITR, GITR-D

Human Chr (Location): 1p36.3; chr1:1203508-1206709 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display dysregulation of T-cell receptor/CD3-driven T-cell activation and programmed cell death.
 
Interactions
Tnfrsf18 interacts with 30 markers (Mir125b-2, Mir210, Mir218-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, positive regulation of cell adhesion, ...
Component external side of plasma membrane, extracellular region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (28)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 25
RT-PCR 10
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tnfrsf18    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010984 (Evidence)
Ensembl Gene Model ENSMUSG00000041954 (Evidence)
Entrez Gene 21936 (Evidence)
UniGene 3180
DFCI TC1584580, TC1595847, TC1661189
DoTS DT.101270277, DT.110831573, DT.483437
NIA Mouse Gene Index U005229
Consensus CDS Project CCDS19056.1, CCDS19057.1
International Mouse Phenotyping Consortium Status Tnfrsf18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010984 VEGA Gene Model | MGI Sequence Detail 2732 C57BL/6J ±  kb
transcript OTTMUST00000025764 VEGA | MGI Sequence Detail 1078 Not Applicable 
polypeptide OTTMUSP00000036862 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 EGF-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022318 Tumour necrosis factor receptor 18
Protein Ontology PR:000016482 tumor necrosis factor receptor superfamily member 18
References
(Earliest) J:40999 Nocentini G, et al., A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6216-21
(Latest) J:210752 Murphy JT, et al., Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice. Blood. 2014 Apr 3;123(14):2172-80
All references(79)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory