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Ldb2
Gene Detail
Symbol

Name
ID
Ldb2
LIM domain binding 2
MGI:894670
Synonyms
CLIM1, CLIM-1a, CLIM-1b, CLP-36, Ldb3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
24.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:44472133-44799707 bp, - strand
From Ensembl annotation of GRCm38

  327575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:989  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LDB2
Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb2

Human
homologs
LDB2, LIM domain binding 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9079
neXtProt AC: NX_O43679

Human Synonyms: CLIM1, LDB1, LDB-2

Human Chr (Location): 4p16; chr4:16501534-16898809 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Radiation induced(2) Targeted(1)
Genomic Mutations involving Ldb2 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in no obvious phenotype.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Ldb2 interacts with 207 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process epithelial structure maintenance, hair follicle development, ...
Component nucleus, transcription factor complex
Function enzyme binding, LIM domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (84)    Tissues (82)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 76
RT-PCR 8
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA LDB2 ; Xenbase ldb2 ; ZFIN ldb2a, ldb2b    NEW 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000039706 (Evidence)
Entrez Gene 16826 (Evidence)
DFCI TC1582170, TC1612074, TC1774420, TC1694632
DoTS DT.99822105, DT.40181101, DT.101381925, DT.99855203
NIA Mouse Gene Index U026165
Consensus CDS Project CCDS19271.1
International Mouse Phenotyping Consortium Status Ldb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039706 Ensembl Gene Model | MGI Sequence Detail 327575 C57BL/6J ±  kb
transcript ENSMUST00000070748 Ensembl | MGI Sequence Detail 2485 Not Applicable 
polypeptide ENSMUSP00000067737 Ensembl | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(20) UniProt(1)
Polymorphisms
SNPs within 2kb(2072 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002691 LIM-domain binding protein
Protein Ontology PR:000009737 LIM domain-binding protein 2
References
(Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(56)
Other
accession IDs
MGI:2140800, MGI:2141166, MGI:894768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory