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Ldb2
Gene Detail
 Symbol
Name
ID
Ldb2
LIM domain binding 2
MGI:894670
Synonyms CLIM1, CLIM-1a, CLIM-1b, CLP-36, Ldb3
Feature Type protein coding gene
Genetic Map
Chromosome 5
24.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:44472133-44799707 bp, - strand
From NCBI annotation of GRCm38

  327575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:989  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LIM-domain-binding protein
Gene Tree: Ldb2

Human
homologs
Human Homolog LDB2, LIM domain binding 2
NCBI Gene ID 9079
neXtProt AC  NX_O43679
Human Synonyms  CLIM1, LDB1
Human Chr (Location)  4p16; chr4:16501541-16898801 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(1)
Genomic Mutations involving Ldb2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in no obvious phenotype.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Ldb2 interacts with 207 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process epithelial structure maintenance, hair follicle development, ...
Component nucleus, transcription factor complex
Function enzyme binding, LIM domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (91)    Tissues (84)    Images (9)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 26, 28
Assay TypeResults
RNA in situ 76
RT-PCR 15
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000039706 (Evidence)
Entrez Gene16826 (Evidence)
DFCITC1582170, TC1612074, TC1694632, TC1774420
DoTSDT.101381925, DT.40181101, DT.99822105, DT.99855203
NIA Mouse Gene IndexU026165
Consensus CDS ProjectCCDS19271.1
International Mouse Knockout Project StatusLdb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16826 NCBI Gene Model | MGI Sequence Detail 327575 C57BL/6J ±  kb
transcript NM_001286348 RefSeq | MGI Sequence Detail 2667 C57BL/6 
polypeptide O55203 UniProt | EBI | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(20) UniProt(1)
Polymorphisms SNPs within 2kb(2072 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002691 LIM-domain binding protein
Protein Ontology PR:000009737 LIM domain-binding protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
(Latest) J:208600 Hunter CS, et al., Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 Mar;62(3):875-86
All references(55)
Other
accession IDs
MGI:2140800, MGI:2141166, MGI:894768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory