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Hbp1
Gene Detail
 Symbol
Name
ID
Hbp1
high mobility group box transcription factor 1
MGI:894659
Synonyms 1700058O05Rik, C330012F01Rik, C86454
Feature Type protein coding gene
Genetic Map
Chromosome 12
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:31926254-31950535 bp, - strand
From VEGA annotation of GRCm38

  24282 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: HMG-box containing protein 1
Gene Tree: Hbp1

Human
homologs
Human Homolog HBP1, HMG-box transcription factor 1
NCBI Gene ID 26959
neXtProt AC  NX_O60381
Human Chr (Location)  7q22-q31; chr7:107168961-107202529 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
 
Mice heterozygous for a gene trapped allele have behavioral abnormalities and show alterations in leukocyte, platelet and NK cell number, blood urea nitrogen levels, and circulating amylase and calcium levels.
 
Interactions
Hbp1 interacts with 257 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of potassium ion transport, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (97)    Tissues (79)    Images (19)
Theiler Stages: 2, 3, 4, 5, 14, 15, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 83
RT-PCR 14
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(28) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000040005 (Evidence)
Ensembl Gene ModelENSMUSG00000002996 (Evidence)
Entrez Gene73389 (Evidence)
DFCITC1577069, TC1587100, TC1601675, TC1608664, TC1609226
NIA Mouse Gene IndexU033886
PDB1S5R, 1V06
Consensus CDS ProjectCCDS25867.2, CCDS25868.2
International Mouse Knockout Project StatusHbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040005 VEGA Gene Model | MGI Sequence Detail 24282 C57BL/6J ±  kb
transcript OTTMUST00000103885 VEGA | MGI Sequence Detail 3142 Not Applicable 
polypeptide OTTMUSP00000058073 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013723 Ataxin-1/HBP1 module (AXH)
InterPro IPR003652 Ataxin, AXH domain
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000008463 HMG box-containing protein 1
References (Earliest) J:38319 Tevosian SG, et al., HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 1997 Feb 1;11(3):383-96
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(49)
Other
accession IDs
MGI:1920639, MGI:1924485, MGI:3034670, MGI:3034710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory