Serpinb8
Gene Detail

Symbol Name ID

Serpinb8 serine (or cysteine) peptidase inhibitor, clade B, member 8 MGI:894657

Synonyms

CAP2, CAP-2, NK10, ovalbumin, Spi8

Feature Type

protein coding gene

Genetic Map

Chromosome 1

50.34 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:107590006-107608909 bp, + strand From VEGA annotation of GRCm38   18904 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpinb8

Human homologs

Human Homolog		SERPINB8, serpin peptidase inhibitor, clade B (ovalbumin), member 8
NCBI Gene ID		5271
neXtProt AC		NX_P50452
Human Synonyms		CAP2, PI8
Human Chr (Location)		18q22.1; chr18:61637263-61656608 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	cytoplasm, cytosol
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020994 (Evidence)
Ensembl Gene Model	ENSMUSG00000026315 (Evidence)
Entrez Gene	20725 (Evidence)
UniGene	83909
DFCI	TC1582709
DoTS	DT.87067894, DT.91575784
Consensus CDS Project	CCDS15220.1
International Mouse Knockout Project Status	Serpinb8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020994	VEGA Gene Model | MGI Sequence Detail	18904	C57BL/6J
transcript	OTTMUST00000049637	VEGA | MGI Sequence Detail	3006	Not Applicable
polypeptide	OTTMUSP00000023031	VEGA | MGI Sequence Detail	374	Not Applicable

All sequences(37) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(227 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR000240	Serpin B9/maspin
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014699	serpin B8

References

(Earliest) J:41085 Sun J, et al., A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem. 1997 Jun 13;272(24):15434-41
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
All references(30)