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Serpinb8 Gene Detail
Summary
  • Symbol
    Serpinb8
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 8
  • Synonyms
    CAP2, CAP-2, NK10, ovalbumin, Spi8
  • Feature Type
    protein coding gene
  • IDs
    MGI:894657
    NCBI Gene: 20725
  • Gene Overview
    MyGene.info: SERPINB8
Location & Maps
more
  • Sequence Map
    Chr1:107590006-107610484 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20479 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 50.34 cM, cytoband D
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SERPINB8, serpin family B member 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SERPINB8, serpin family B member 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAP2, PI8
  • Links
    NCBI Gene ID: 5271
    neXtProt AC: NX_P50452

  • Chr Location
    18q22.1; chr18:63970028-64006821 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Serpinb8
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020994 VEGA Gene Model | MGI Sequence Detail 20479 C57BL/6J ±  kb
transcript OTTMUST00000049638 VEGA | MGI Sequence Detail 3001 Not Applicable  
polypeptide OTTMUSP00000023032 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    264 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:41085 Sun J, et al., A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem. 1997 Jun 13;272(24):15434-41
  • Latest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory