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Serpinb8
Gene Detail
 Symbol
Name
ID
Serpinb8
serine (or cysteine) peptidase inhibitor, clade B, member 8
MGI:894657
Synonyms CAP2, CAP-2, NK10, ovalbumin, Spi8
Feature Type protein coding gene
Genetic Map
Chromosome 1
50.34 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:107590006-107608909 bp, + strand
From VEGA annotation of GRCm38

  18904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpinb8

Human
homologs
Human Homolog SERPINB8, serpin peptidase inhibitor, clade B (ovalbumin), member 8
NCBI Gene ID 5271
neXtProt AC  NX_P50452
Human Synonyms  CAP2, PI8
Human Chr (Location)  18q22.1; chr18:63970028-63989374 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Serpinb8 interacts with 225 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component cytoplasm, cytosol, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020994 (Evidence)
Ensembl Gene ModelENSMUSG00000026315 (Evidence)
Entrez Gene20725 (Evidence)
UniGene83909
DFCITC1582709
DoTSDT.87067894, DT.91575784
Consensus CDS ProjectCCDS15220.1
International Mouse Knockout Project StatusSerpinb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020994 VEGA Gene Model | MGI Sequence Detail 18904 C57BL/6J ±  kb
transcript OTTMUST00000049637 VEGA | MGI Sequence Detail 3006 Not Applicable 
polypeptide OTTMUSP00000023031 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR000240 Serpin B9/maspin
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014699 serpin B8
References (Earliest) J:41085 Sun J, et al., A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem. 1997 Jun 13;272(24):15434-41
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory