Hlcs
Gene Detail

Symbol Name ID

Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) MGI:894646

Synonyms

410I21.SP6, D16Jhu34

Feature Type

protein coding gene

Genetic Map

Chromosome 16

55.12 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:94129306-94287856 bp, - strand From NCBI annotation of GRCm38   158551 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: biotin--protein ligase
Gene Tree: Hlcs

Human homologs

Human Homolog		HLCS, holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
NCBI Gene ID		3141
neXtProt AC		NX_P50747
Human Synonyms		HCS
Human Chr (Location)		21q22.13; chr21:38123189-38362545 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HLCS

Alleles and phenotypes

All alleles(3) : Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cell proliferation, cellular protein modification process, ...
Component	chromatin, cytoplasm, ...
Function	ATP binding, biotin-[acetyl-CoA-carboxylase] ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (161)    Tissues (133)    Images (2)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	143
RT-PCR	18

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(7) cDNA(10) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000040820 (Evidence)
Entrez Gene	110948 (Evidence)
DFCI	TC1583235
DoTS	DT.101172227, DT.101319414, DT.489008, DT.91331535
NIA Mouse Gene Index	U037326
EC	6.3.4.-, 6.3.4.10, 6.3.4.11, 6.3.4.15, 6.3.4.9
Consensus CDS Project	CCDS28346.1
International Mouse Knockout Project Status	Hlcs

Sequences

Length	Strain/Species
genomic	110948	NCBI Gene Model | MGI Sequence Detail	158551	C57BL/6J
transcript	NM_139145	RefSeq | MGI Sequence Detail	4833	C57BL/6
polypeptide	Q920N2	UniProt | EBI | MGI Sequence Detail	722	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(665 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004408	Biotin--acetyl-CoA-carboxylase ligase
InterPro	IPR004143	Biotin/lipoate A/B protein ligase
InterPro	IPR003142	Biotin protein ligase, C-terminal
Protein Ontology	PR:000008617	biotin--protein ligase

Graphical View of Protein Domain Structure

References

(Earliest) J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
All references(39)

Other accession IDs

MGI:1338005