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Hlcs
Gene Detail
 Symbol
Name
ID
Hlcs
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
MGI:894646
Synonyms 410I21.SP6, D16Jhu34
Feature Type protein coding gene
Genetic Map
Chromosome 16
55.12 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:94129306-94287856 bp, - strand
From NCBI annotation of GRCm38

  158551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: biotin--protein ligase
Gene Tree: Hlcs

Human
homologs
Human Homolog HLCS, holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
NCBI Gene ID 3141
neXtProt AC  NX_P50747
Human Synonyms  HCS
Human Chr (Location)  21q22.13; chr21:36750888-36990245 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLCS
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Genomic Mutations involving Hlcs (2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hlcs interacts with 291 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell proliferation, cellular protein modification process, ...
Component chromatin, cytoplasm, ...
Function ATP binding, biotin-[acetyl-CoA-carboxylase] ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (161)    Tissues (133)    Images (2)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 143
RT-PCR 18
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(7) cDNA(30) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040820 (Evidence)
Entrez Gene110948 (Evidence)
UniGene30921
DFCITC1583235, TC1645999
DoTSDT.101172227, DT.101319414, DT.489008, DT.91331535
NIA Mouse Gene IndexU037326
EC6.3.4.-, 6.3.4.10, 6.3.4.11, 6.3.4.15, 6.3.4.9
Consensus CDS ProjectCCDS28346.1
International Mouse Knockout Project StatusHlcs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 110948 NCBI Gene Model | MGI Sequence Detail 158551 C57BL/6J ±  kb
transcript NM_139145 RefSeq | MGI Sequence Detail 4833 C57BL/6 
polypeptide Q920N2 UniProt | EBI | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(20) UniProt(3)
Polymorphisms SNPs within 2kb(754 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004408 Biotin--acetyl-CoA-carboxylase ligase
InterPro IPR004143 Biotin/lipoate A/B protein ligase
InterPro IPR003142 Biotin protein ligase, C-terminal
Protein Ontology PR:000008617 biotin--protein ligase
Graphical View of Protein Domain Structure
References (Earliest) J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
All references(40)
Other
accession IDs
MGI:1338005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory