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Hlcs
Gene Detail
Symbol

Name
ID
Hlcs
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
MGI:894646
Synonyms
410I21.SP6, D16Jhu34
Feature Type
protein coding gene
Genetic Map
Chromosome 16
55.12 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:94129195-94313563 bp, - strand
From Ensembl annotation of GRCm38

  184369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HLCS
Protein SuperFamily: biotin--protein ligase
Gene Tree: Hlcs

Human
homologs
HLCS, holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3141
neXtProt AC: NX_P50747

Human Synonyms: HCS

Human Chr (Location): 21q22.13; chr21:36750888-36990246 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HLCS

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(15) Targeted(5)
Genomic Mutations involving Hlcs (5)
Incidental mutations (data from Mutagenetix , APF )
Mutations Annotated to Human Diseases (1)   
Interactions
Hlcs interacts with 291 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell proliferation, cellular protein modification process, ...
Component chromatin, cytoplasm, ...
Function ATP binding, biotin-[acetyl-CoA-carboxylase] ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (161)    Tissues (134)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
RT-PCR 18
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hlcs    NEW 
Molecular
reagents
All nucleic(40) Genomic(7) cDNA(30) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000040820 (Evidence)
Entrez Gene 110948 (Evidence)
UniGene 30921
DFCI TC1583235, TC1645999
DoTS DT.101172227, DT.101319414, DT.489008, DT.91331535
NIA Mouse Gene Index U037326
EC 6.3.4.-, 6.3.4.10, 6.3.4.11, 6.3.4.15, 6.3.4.9
Consensus CDS Project CCDS28346.1
International Mouse Phenotyping Consortium Status Hlcs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040820 Ensembl Gene Model | MGI Sequence Detail 184369 C57BL/6J ±  kb
transcript ENSMUST00000163193 Ensembl | MGI Sequence Detail 5060 Not Applicable 
polypeptide ENSMUSP00000130981 Ensembl | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(20) UniProt(3)
Polymorphisms
SNPs within 2kb(781 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004408 Biotin--acetyl-CoA-carboxylase ligase
InterPro IPR004143 Biotin/lipoate A/B protein ligase
InterPro IPR003142 Biotin protein ligase, C-terminal
Protein Ontology PR:000008617 biotin--protein ligase
References
(Earliest) J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(40)
Other
accession IDs
MGI:1338005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory