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Hlcs Gene Detail
Summary
  • Symbol
    Hlcs
  • Name
    holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
  • Synonyms
    410I21.SP6, D16Jhu34
  • Feature Type
    protein coding gene
  • IDs
    MGI:894646
    NCBI Gene: 110948
Location & Maps
more
  • Sequence Map
    Chr16:94129195-94313563 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      184369 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HLCS, holocarboxylase synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HLCS, holocarboxylase synthetase
    Orthology source: HomoloGene
  • Synonyms
    HCS
  • Links
    NCBI Gene ID: 3141
    neXtProt AC: NX_P50747

  • Chr Location
    21q22.13; chr21:36750888-36990246 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HLCS associations

Human Disease Mouse Models
       Holocarboxylase Synthetase Deficiency   OMIM: 253270
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    26 phenotype references
  • All Mutations and Alleles
    25
  • Gene trapped
    15
  • Targeted
    8
  • Transgenic
    2
  • Genomic Mutations
    8 involving Hlcs
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040820 Ensembl Gene Model | MGI Sequence Detail 184369 C57BL/6J ±  kb
transcript ENSMUST00000163193 Ensembl | MGI Sequence Detail 5060 Not Applicable  
polypeptide ENSMUSP00000130981 Ensembl | MGI Sequence Detail 722 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    778 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    Genomic 7
    cDNA 30
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1338005
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory