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Pick1 Gene Detail
Summary
  • Symbol
    Pick1
  • Name
    protein interacting with C kinase 1
  • Synonyms
    Prkcabp
  • Feature Type
    protein coding gene
  • IDs
    MGI:894645
    NCBI Gene: 18693
  • Gene Overview
    MyGene.info: PICK1
Location & Maps
more
  • Sequence Map
    Chr15:79229173-79256674 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27502 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PICK1, protein interacting with PRKCA 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PICK1, protein interacting with PRKCA 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PICK, PRKCABP
  • Links
    NCBI Gene ID: 9463
    neXtProt AC: NX_Q9NRD5

  • Chr Location
    22q13.1; chr22:38056420-38075701 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7470
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PICK1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    5 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Pick1
  • Incidental Mutations
    APF
Mice homozygous for a null allele show impaired synaptic plasticity and lack of long-term depression; males are infertile due to reduced sperm count and impaired sperm motility, and display small testes and seminiferous tubules, malformed acrosomes, globozoospermia, and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036025 VEGA Gene Model | MGI Sequence Detail 27502 C57BL/6J ±  kb
transcript OTTMUST00000092450 VEGA | MGI Sequence Detail 2415 Not Applicable  
polypeptide OTTMUSP00000051100 VEGA | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR030798 Arfaptin family
    IPR010504 Arfaptin homology (AH) domain
    IPR027267 Arfaptin homology (AH) domain/BAR domain
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR001079 Galectin, carbohydrate recognition domain
    IPR001478 PDZ domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 65
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 11
    Phenotypes 41
  • Earliest
    J:41185 Staudinger J, et al., PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995 Feb;128(3):263-71
  • Latest
    J:221875 Mignogna ML, et al., The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition. Nat Commun. 2015;6:6504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory