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Tmem165 Gene Detail
Summary
  • Symbol
    Tmem165
  • Name
    transmembrane protein 165
  • Synonyms
    pFT27, Tpardl, Tparl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894407
    NCBI Gene: 21982
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76183880-76209244 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.56 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894407
protein coding gene Chr5:76183880-76209245 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029641
protein coding gene Chr5:76360485-76385135 (+)
A/J MGP_AJ_G0029609
protein coding gene Chr5:73436243-73464142 (+)
AKR/J MGP_AKRJ_G0029557
protein coding gene Chr5:75823056-75852737 (+)
BALB/cJ MGP_BALBcJ_G0029618
protein coding gene Chr5:74181107-74205696 (+)
C3H/HeJ MGP_C3HHeJ_G0029341
protein coding gene Chr5:76211470-76239030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030072
protein coding gene Chr5:79421868-79451093 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027313
protein coding gene Chr5:69096227-69124539 (+)
CAST/EiJ MGP_CASTEiJ_G0028749
protein coding gene Chr5:75394177-75420186 (+)
CBA/J MGP_CBAJ_G0029310
protein coding gene Chr5:82009232-82033798 (+)
DBA/2J MGP_DBA2J_G0029455
protein coding gene Chr5:73513275-73545147 (+)
FVB/NJ MGP_FVBNJ_G0029416
protein coding gene Chr5:72691546-72719822 (+)
LP/J MGP_LPJ_G0029542
protein coding gene Chr5:76801219-76825931 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029444
protein coding gene Chr5:85191079-85219568 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030105
protein coding gene Chr5:75391047-75416638 (+)
PWK/PhJ MGP_PWKPhJ_G0028472
protein coding gene Chr5:72519739-72549042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028307
protein coding gene Chr5:74750760-74782119 (+)
WSB/EiJ MGP_WSBEiJ_G0028829
protein coding gene Chr5:75695720-75724444 (+)



Homology
more
  • Human Ortholog
    TMEM165, transmembrane protein 165
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMEM165, transmembrane protein 165
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDG2K, FT27, GDT1, TMPT27, TPARL
  • Links
    NCBI Gene ID: 55858
    neXtProt AC: NX_Q9HC07
    UniProt: Q9HC07

  • Chr Location
    4q12; chr4:55395913-55453397 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TMEM165 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Spontaneous
    2
  • Targeted
    3
  • Genomic Mutations
    5 involving Tmem165
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21982 NCBI Gene Model | MGI Sequence Detail 25365 C57BL/6J ±  kb
transcript NM_011626 RefSeq | MGI Sequence Detail 1896 C57BL/6  
polypeptide P52875 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    Genomic 4
    cDNA 123

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141106
References
more
  • Summaries
    All 39
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:276293 Snyder NA, et al., Milk biosynthesis requires the Golgi cation exchanger TMEM165. J Biol Chem. 2019 Mar 1;294(9):3181-3191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory