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Tmem165 Gene Detail
Summary
  • Symbol
    Tmem165
  • Name
    transmembrane protein 165
  • Synonyms
    pFT27, Tpardl, Tparl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894407
    NCBI Gene: 21982
Location & Maps
more
  • Sequence Map
    Chr5:76183880-76209245 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25366 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.56 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TMEM165, transmembrane protein 165
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMEM165, transmembrane protein 165
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDG2K, FT27, GDT1, TMPT27, TPARL
  • Links
    NCBI Gene ID: 55858
    neXtProt AC: NX_Q9HC07

  • Chr Location
    4q12; chr4:55395913-55452974 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TMEM165 associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type Iik; CDG2K   OMIM: 614727
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Tmem165
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026458 VEGA Gene Model | MGI Sequence Detail 25366 C57BL/6J ±  kb
transcript OTTMUST00000065429 VEGA | MGI Sequence Detail 1897 Not Applicable  
polypeptide OTTMUSP00000032613 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    187 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 126
    Genomic 4
    cDNA 122

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141106
References
more
  • Summaries
    All 34
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:39942 Akagi J, et al., Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein. Biochem Biophys Res Commun. 1988 Dec 15;157(2):548-57
  • Latest
    J:233978 Mizuno S, et al., Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Sci Rep. 2015;5:13632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory