Ebf2 MGI Mouse Gene Detail - MGI:894332

Symbol

Ebf2
Name

early B cell factor 2
Synonyms

D14Ggc1e, Mmot1, O/E-3

Feature Type

protein coding gene
IDs

MGI:894332
NCBI Gene: 13592
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:67233292-67430918 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.63 cM, cytoband D-E1
Mapping Data

7 experiments

SNPs within 2kb

907 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894332	protein coding gene	Chr14:67233292-67430952 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021503	protein coding gene	Chr14:61954848-62158953 (+)
A/J	MGP_AJ_G0021462	protein coding gene	Chr14:60465053-60667868 (+)
AKR/J	MGP_AKRJ_G0021438	protein coding gene	Chr14:62539380-62742553 (+)
BALB/cJ	MGP_BALBcJ_G0021468	protein coding gene	Chr14:60461370-60663282 (+)
C3H/HeJ	MGP_C3HHeJ_G0021245	protein coding gene	Chr14:62265658-62466083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021907	protein coding gene	Chr14:64775925-64989960 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019447	protein coding gene	Chr14:58375521-58576239 (+)
CAST/EiJ	MGP_CASTEiJ_G0020762	protein coding gene	Chr14:58745846-58957961 (+)
CBA/J	MGP_CBAJ_G0021212	protein coding gene	Chr14:66762626-66980907 (+)
DBA/2J	MGP_DBA2J_G0021335	protein coding gene	Chr14:60104561-60304715 (+)
FVB/NJ	MGP_FVBNJ_G0021314	protein coding gene	Chr14:59509878-59710563 (+)
LP/J	MGP_LPJ_G0021410	protein coding gene	Chr14:63012957-63218440 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021343	protein coding gene	Chr14:65765231-65976986 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021930	protein coding gene	Chr14:61765004-61972440 (+)
PWK/PhJ	MGP_PWKPhJ_G0020506	protein coding gene	Chr14:56856778-57060059 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020339	protein coding gene	Chr14:57734005-57934898 (+)
WSB/EiJ	MGP_WSBEiJ_G0020815	protein coding gene	Chr14:62086498-62295621 (+)

Human Ortholog

EBF2, EBF transcription factor 2

Vertebrate Orthologs

10

Human Ortholog

EBF2, EBF transcription factor 2
Orthology source: HomoloGene, HGNC
Synonyms

COE2, EBF-2, O/E-3, OE-3
Links

HGNC:19090

NCBI Gene ID: 64641

neXtProt AC: NX_Q9HAK2

UniProt: Q9HAK2
Chr Location

8p21.2; chr8:25841730-26045124 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56471
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: EBF2
Protein SuperFamily

transcription factor, collier type
Gene Tree

Ebf2

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Phenotype Summary

45 phenotypes from 8 alleles in 9 genetic backgrounds
4 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

8
Genomic Mutations

1 involving Ebf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

2

Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.

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All GO Annotations

21
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

268
Tissues

210
cDNA Data

44
Literature Summary

49

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EBF2

Xenbase ebf2

ZFIN ebf2

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Ebf2 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS27228.1
UniGene

319947

Ensembl

ENSMUSG00000022053 (Evidence)
NCBI Gene

13592

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022053	Ensembl Gene Model \| MGI Sequence Detail	197627	C57BL/6J	± kb
transcript	ENSMUST00000022637	Ensembl \| MGI Sequence Detail	4352	Not Applicable
polypeptide	ENSMUSP00000022637	Ensembl \| MGI Sequence Detail	575	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006867 transcription factor COE2

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR003523 Transcription factor COE

IPR018350 Transcription factor COE, conserved site

IPR032200 Transcription factor COE, DNA-binding domain

IPR038173 Transcription factor COE, DNA-binding domain superfamily

IPR032201 Transcription factor COE, helix-loop-helix domain

IPR038006 Transcription factor COE, IPT domain

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All nucleic 50

cDNA 45

Primer pair 3

Other 2

Microarray probesets 5

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MGD-MRK-34015, MGI:106323, MGI:894328

Summaries

All 93

Developmental Gene Expression 49

Gene Ontology 7

Phenotypes 25
Earliest

J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
Latest

J:272505 Catela C, et al., An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2

TSS for Ebf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126327	Chr14:67233182-67233208 (+)	-97 bp
Tssr126328	Chr14:67233286-67233346 (+)	24 bp
Tssr126329	Chr14:67233435-67233456 (+)	154 bp
Tssr126330	Chr14:67233902-67233910 (+)	614 bp
Tssr126331	Chr14:67234588-67234617 (+)	1,311 bp
Tssr126332	Chr14:67234620-67234645 (+)	1,341 bp
Tssr126333	Chr14:67234731-67234736 (+)	1,442 bp
Tssr126334	Chr14:67234795-67234837 (+)	1,524 bp
Tssr126335	Chr14:67234845-67234865 (+)	1,563 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14