Ebf2 MGI Mouse Gene Detail - MGI:894332

Ebf2 Gene Detail

Symbol

Ebf2
Name

early B cell factor 2
Synonyms

D14Ggc1e, Mmot1, O/E-3

Feature Type

protein coding gene
IDs

MGI:894332
NCBI Gene: 13592
Alliance

gene page

Sequence Map

Chr14:67233292-67430918 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

197627 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.63 cM, cytoband D-E1
Mapping Data

7 experiments

Human Ortholog

EBF2, early B-cell factor 2

Vertebrate Orthologs

10

Human Ortholog

EBF2, early B-cell factor 2
Orthology source: HomoloGene, HGNC
Synonyms

COE2, EBF-2, O/E-3, OE-3
Links

HGNC:19090

NCBI Gene ID: 64641

neXtProt AC: NX_Q9HAK2

UniProt: Q9HAK2
Chr Location

8p21.2; chr8:25841730-26045124 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56471
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: EBF2
Protein SuperFamily

transcription factor, collier type
Gene Tree

Ebf2

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Phenotype Summary

45 phenotypes from 8 alleles in 9 genetic backgrounds
4 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Targeted

8
Genomic Mutations

1 involving Ebf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.

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All GO Annotations

18
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

205
Tissues

164
cDNA Data

41
Literature Summary

45

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EBF2

ZFIN ebf2

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Ebf2 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS27228.1
UniGene

319947

			Length	Strain/Species	Flank
genomic	OTTMUSG00000040034	VEGA Gene Model \| MGI Sequence Detail	197627	C57BL/6J	± kb
transcript	OTTMUST00000103954	VEGA \| MGI Sequence Detail	4352	Not Applicable
polypeptide	OTTMUSP00000058129	VEGA \| MGI Sequence Detail	575	Not Applicable

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SNPs within 2kb

907 from dbSNP Build 142

PCR

1

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UniProt

1 Sequence
Protein Ontology

PR:000006867 transcription factor COE2

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR003523 Transcription factor COE

IPR018350 Transcription factor COE, conserved site

IPR032200 Transcription factor COE, DNA-binding domain

IPR032201 Transcription factor COE, helix-loop-helix domain

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All nucleic 46

cDNA 42

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-34015, MGI:106323, MGI:894328

Summaries

All 82

Developmental Gene Expression 45

Gene Ontology 5

Phenotypes 22
Earliest

J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
Latest

J:242983 Shapira SN, et al., EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes Dev. 2017 Apr 01;31(7):660-673

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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