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Ebf2
Gene Detail
Symbol

Name
ID
Ebf2
early B cell factor 2
MGI:894332
Synonyms
D14Ggc1e, Mmot1, O/E-3
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.63 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:67233292-67430918 bp, + strand
From VEGA annotation of GRCm38

  197627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, collier type
Gene Tree: Ebf2

Human
homologs
Human Homolog EBF2, early B-cell factor 2
NCBI Gene ID 64641
neXtProt AC  NX_Q9HAK2
Human Synonyms  COE2, EBF-2, O/E-3, OE-3
Human Chr (Location)  8p21.2; chr8:25841730-26045124 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.
 
Interactions
Ebf2 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process adipose tissue development, brown fat cell differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (203)    Tissues (163)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 10
cDNA source data(41)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(42) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000040034 (Evidence)
Ensembl Gene ModelENSMUSG00000022053 (Evidence)
Entrez Gene13592 (Evidence)
UniGene319947
DFCITC1581082, TC1650595
DoTSDT.486654, DT.94148087, DT.97351761
NIA Mouse Gene IndexU015793
Consensus CDS ProjectCCDS27228.1
International Mouse Knockout Project StatusEbf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040034 VEGA Gene Model | MGI Sequence Detail 197627 C57BL/6J ±  kb
transcript OTTMUST00000103957 VEGA | MGI Sequence Detail 2784 Not Applicable 
polypeptide OTTMUSP00000058131 VEGA | MGI Sequence Detail 575 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(918 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003523 Transcription factor COE
InterPro IPR018350 Transcription factor COE, conserved site
Protein Ontology PR:000006867 transcription factor COE2
References
(Earliest) J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
(Latest) J:203672 Hoxha E, et al., Motor dysfunction and cerebellar Purkinje cell firing impairment in Ebf2 null mice. Mol Cell Neurosci. 2013 Jan;52:51-61
All references(78)
Other
accession IDs
MGD-MRK-34015, MGI:106323, MGI:894328

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory