Ebf2
Gene Detail

Symbol

Name
ID

Ebf2
early B cell factor 2
MGI:894332

Synonyms

D14Ggc1e, Mmot1, O/E-3

Feature Type

protein coding gene

Genetic Map

Chromosome 14
34.63 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr14:67233292-67430918 bp, + strand From VEGA annotation of GRCm38   197627 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, collier type
Gene Tree: Ebf2

Human
homologs

Human Homolog		EBF2, early B-cell factor 2
NCBI Gene ID		64641
neXtProt AC		NX_Q9HAK2
Human Synonyms		COE2, EBF-2, O/E-3, OE-3
Human Chr (Location)		8p21.2; chr8:25841730-26045124 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.

 

Interactions

Ebf2 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	adipose tissue development, brown fat cell differentiation, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (42 records)

Data Summary: Results (203)    Tissues (163)    Images (33)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	193
RT-PCR	10

cDNA source data(41)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(45) cDNA(42) Primer pair(3)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000040034 (Evidence)
Ensembl Gene Model	ENSMUSG00000022053 (Evidence)
Entrez Gene	13592 (Evidence)
UniGene	319947
DFCI	TC1650595, TC1581082
DoTS	DT.486654, DT.94148087, DT.97351761
NIA Mouse Gene Index	U015793
Consensus CDS Project	CCDS27228.1
International Mouse Knockout Project Status	Ebf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040034	VEGA Gene Model | MGI Sequence Detail	197627	C57BL/6J
transcript	OTTMUST00000103954	VEGA | MGI Sequence Detail	4352	Not Applicable
polypeptide	OTTMUSP00000058129	VEGA | MGI Sequence Detail	575	Not Applicable

All sequences(39) RefSeq(6) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(918 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR003523	Transcription factor COE
InterPro	IPR018350	Transcription factor COE, conserved site
Protein Ontology	PR:000006867	transcription factor COE2

References

(Earliest) J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
(Latest) J:216370 Wang W, et al., Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71
All references(79)

Other
accession IDs

MGD-MRK-34015, MGI:106323, MGI:894328