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Ebf2 Gene Detail
Summary
  • Symbol
    Ebf2
  • Name
    early B cell factor 2
  • Synonyms
    D14Ggc1e, Mmot1, O/E-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894332
    NCBI Gene: 13592
Location & Maps
more
  • Sequence Map
    Chr14:67233292-67430918 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      197627 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EBF2, early B-cell factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EBF2, early B-cell factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COE2, EBF-2, O/E-3, OE-3
  • Links
    NCBI Gene ID: 64641
    neXtProt AC: NX_Q9HAK2

  • Chr Location
    8p21.2; chr8:25841730-26045124 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Ebf2
  • Incidental Mutations
Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040034 VEGA Gene Model | MGI Sequence Detail 197627 C57BL/6J ±  kb
transcript OTTMUST00000103955 VEGA | MGI Sequence Detail 5204 Not Applicable  
polypeptide OTTMUSP00000058130 VEGA | MGI Sequence Detail 575 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    918 from dbSNP Build 137
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006867 transcription factor COE2
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR002909 IPT domain
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003523 Transcription factor COE
    IPR018350 Transcription factor COE, conserved site
    IPR032200 Transcription factor COE, DNA-binding domain
    IPR032201 Transcription factor COE, helix-loop-helix domain
Molecular
Reagents
less
  • All nucleic 45
    cDNA 42
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-34015, MGI:106323, MGI:894328
References
more
  • Summaries
    All 75
    Developmental Gene Expression 42
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
  • Latest
    J:216370 Wang W, et al., Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory