Ebf2 MGI Mouse Gene Detail - MGI:894332

Symbol

Ebf2
Name

early B cell factor 2
Synonyms

D14Ggc1e, Mmot1, O/E-3

Feature Type

protein coding gene
IDs

MGI:894332
NCBI Gene: 13592
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr14:67470741-67668367 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.63 cM, cytoband D-E1
Mapping Data

7 experiments

SNPs within 2kb

4581 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894332	protein coding gene	Chr14:67470741-67668401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021503	protein coding gene	Chr14:61954848-62158953 (+)
A/J	MGP_AJ_G0021462	protein coding gene	Chr14:60465053-60667868 (+)
AKR/J	MGP_AKRJ_G0021438	protein coding gene	Chr14:62539380-62742553 (+)
BALB/cJ	MGP_BALBcJ_G0021468	protein coding gene	Chr14:60461370-60663282 (+)
C3H/HeJ	MGP_C3HHeJ_G0021245	protein coding gene	Chr14:62265658-62466083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021907	protein coding gene	Chr14:64775925-64989960 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019447	protein coding gene	Chr14:58375521-58576239 (+)
CAST/EiJ	MGP_CASTEiJ_G0020762	protein coding gene	Chr14:58745846-58957961 (+)
CBA/J	MGP_CBAJ_G0021212	protein coding gene	Chr14:66762626-66980907 (+)
DBA/2J	MGP_DBA2J_G0021335	protein coding gene	Chr14:60104561-60304715 (+)
FVB/NJ	MGP_FVBNJ_G0021314	protein coding gene	Chr14:59509878-59710563 (+)
LP/J	MGP_LPJ_G0021410	protein coding gene	Chr14:63012957-63218440 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021343	protein coding gene	Chr14:65765231-65976986 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021930	protein coding gene	Chr14:61765004-61972440 (+)
PWK/PhJ	MGP_PWKPhJ_G0020506	protein coding gene	Chr14:56856778-57060059 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020339	protein coding gene	Chr14:57734005-57934898 (+)
WSB/EiJ	MGP_WSBEiJ_G0020815	protein coding gene	Chr14:62086498-62295621 (+)

Human Ortholog

EBF2, EBF transcription factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EBF2, EBF transcription factor 2
Synonyms

COE2, EBF-2, O/E-3, OE-3
Links

HGNC:19090

NCBI Gene ID: 64641

UniProt: Q9HAK2
Chr Location

8p21.2; chr8:25841725-26045413 (-) GRCh38

MGI Vertebrate Homology

Ebf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EBF2
Gene Tree

Ebf2

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Phenotype Summary

71 phenotypes from 9 alleles in 10 genetic backgrounds
4 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

9
Genomic Mutations

1 involving Ebf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.

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All GO Annotations

27
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1096
Tissues

266
cDNA Data

47
Literature Summary

71

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EBF2

Xenbase ebf2

ZFIN ebf2

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS27228.1

Ensembl

ENSMUSG00000022053 (Evidence)
NCBI Gene

13592

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022053	Ensembl Gene Model \| MGI Sequence Detail	197627	C57BL/6J	± kb
transcript	ENSMUST00000022637	Ensembl \| MGI Sequence Detail	4352	Not Applicable
polypeptide	ENSMUSP00000022637	Ensembl \| MGI Sequence Detail	575	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006867 transcription factor COE2

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR003523 Transcription factor COE

IPR018350 Transcription factor COE, conserved site

IPR032200 Transcription factor COE, DNA-binding domain

IPR038173 Transcription factor COE, DNA-binding domain superfamily

IPR032201 Transcription factor COE, helix-loop-helix domain

IPR038006 Transcription factor COE, IPT domain
GlyGen

O08792 1 site

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All nucleic 60

cDNA 49

Primer pair 6

Other 5

Microarray probesets 5

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MGD-MRK-34015, MGI:106323, MGI:894328

Summaries

All 124

Developmental Gene Expression 71

Gene Ontology 10

Phenotypes 31
Earliest

J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
Latest

J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465

TSS for Ebf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126327	Chr14:67470631-67470657 (+)	-97 bp
Tssr126328	Chr14:67470735-67470795 (+)	24 bp
Tssr126329	Chr14:67470884-67470905 (+)	154 bp
Tssr126330	Chr14:67471351-67471359 (+)	614 bp
Tssr126331	Chr14:67472037-67472066 (+)	1,311 bp
Tssr126332	Chr14:67472069-67472094 (+)	1,341 bp
Tssr126333	Chr14:67472180-67472185 (+)	1,442 bp
Tssr126334	Chr14:67472244-67472286 (+)	1,524 bp
Tssr126335	Chr14:67472294-67472314 (+)	1,563 bp
Tssr126336	Chr14:67475157-67475194 (+)	4,435 bp
Tssr126337	Chr14:67493969-67493972 (+)	23,230 bp
Tssr126339	Chr14:67536793-67536797 (+)	66,054 bp
Tssr126340	Chr14:67553567-67553570 (+)	82,828 bp
Tssr126341	Chr14:67636275-67636314 (+)	165,554 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24