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Ranbp2 Gene Detail
Summary
  • Symbol
    Ranbp2
  • Name
    RAN binding protein 2
  • Synonyms
    A430087B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894323
    NCBI Gene: 19386
Location & Maps
more
  • Sequence Map
    Chr10:58446852-58494155 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47304 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    RANBP2, RAN binding protein 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RANBP2, RAN binding protein 2
    Orthology source: HGNC
  • Synonyms
    ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2
  • Links
    NCBI Gene ID: 5903
    neXtProt AC: NX_P49792

  • Chr Location
    2q12.3; chr2:108719446-108785811 (+)  GRCh38.p2

  • Human Ortholog
    RGPD1, RANBP2-like and GRIP domain containing 1
    Orthology source: HomoloGene
  • Synonyms
    RanBP2L2, RGP1, RGPD2
  • Links
    NCBI Gene ID: 400966
    neXtProt AC: NX_P0DJD0

  • Chr Location
    2p11.2; chr2:86913573-87013976 (+)  GRCh38.p2

  • Human Ortholog
    RGPD2, RANBP2-like and GRIP domain containing 2
    Orthology source: HomoloGene
  • Synonyms
    NUP358, RANBP2L2, RGP2
  • Links
    NCBI Gene ID: 729857
    neXtProt AC: NX_P0DJD1

  • Chr Location
    2p11.2; chr2:87757198-87985814 (-)  GRCh38.p2

  • Human Ortholog
    RGPD3, RANBP2-like and GRIP domain containing 3
    Orthology source: HomoloGene
  • Synonyms
    RGP3
  • Links
    NCBI Gene ID: 653489
    neXtProt AC: NX_A6NKT7

  • Chr Location
    2q13; chr2:106391360-106468345 (-)  GRCh38.p2

  • Human Ortholog
    RGPD4, RANBP2-like and GRIP domain containing 4
    Orthology source: HomoloGene
  • Synonyms
    RGP4
  • Links
    NCBI Gene ID: 285190
    neXtProt AC: NX_Q7Z3J3

  • Chr Location
    2q12.3; chr2:107826932-107892544 (+)  GRCh38.p2

  • Human Ortholog
    RGPD5, RANBP2-like and GRIP domain containing 5
    Orthology source: HomoloGene
  • Synonyms
    BS63, BS-63, HEL161, RGP5
  • Links
    NCBI Gene ID: 84220
    neXtProt AC: NX_Q99666

  • Chr Location
    2q13; chr2:109760607-109857691 (+)  GRCh38.p2

  • Human Ortholog
    RGPD6, RANBP2-like and GRIP domain containing 6
    Orthology source: HomoloGene
  • Synonyms
    RanBP2L1, RanBP2L2, RGP6, RGPD7
  • Links
    NCBI Gene ID: 729540
    neXtProt AC: NX_Q99666

  • Chr Location
    2q13; chr2:110513802-110610888 (-)  GRCh38.p2

  • Human Ortholog
    RGPD8, RANBP2-like and GRIP domain containing 8
    Orthology source: HomoloGene
  • Synonyms
    RanBP2alpha, RANBP2L1, RGP8
  • Links
    NCBI Gene ID: 727851
    neXtProt AC: NX_O14715

  • Chr Location
    2q13; chr2:112368369-112433645 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RANBP2 associations

Human Disease Mouse Models
       Encephalopathy, Acute, Infection-Induced, Susceptibility to, 3; IIAE3   OMIM: 608033
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Ranbp2
  • Incidental Mutations
Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified  
polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    100 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR022011 Nup358/RanBP2 E3 ligase domain
    IPR011993 PH domain-like
    IPR000156 Ran binding domain
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
    IPR001876 Zinc finger, RanBP2-type
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143551, MGI:2443460
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:33514 Wilken N, et al., Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995 Nov;68(3):211-9
  • Latest
    J:209507 Cho KI, et al., Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem. 2014 Feb 21;289(8):4600-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory