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Ranbp2
Gene Detail
Symbol

Name
ID
Ranbp2
RAN binding protein 2
MGI:894323
Synonyms
A430087B05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:58446852-58494155 bp, + strand
From NCBI annotation of GRCm38

  47304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87808  Vertebrate Homology Class
7 human; 1 mouse; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RANBP2, RGPD1, RGPD2, RGPD3, RGPD4, RGPD5, RGPD6, RGPD8
Protein SuperFamily: Ran-binding protein 2
Gene Tree: Ranbp2

Human
homologs
RANBP2, RAN binding protein 2
Orthology source: HGNC

IDs:
NCBI Gene ID: 5903
neXtProt AC: NX_P49792

Human Synonyms: ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2

Human Chr (Location): 2q12.3; chr2:108719446-108785811 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RANBP2

  7 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.
 
Interactions
Ranbp2 interacts with 216 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process intracellular transport, mRNA transport, ...
Component membrane, mitochondrion, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (76)    Tissues (26)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
Western blot 1
RT-PCR 15
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ranbp2    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000003226 (Evidence)
Entrez Gene 19386 (Evidence)
DFCI TC1574641, TC1589713, TC1615431, TC1663326, TC1663728, TC1690452
DoTS DT.101708068, DT.103567282, DT.110612682, DT.492970, DT.524631, DT.55233565, DT.91334332, DT.99851291
NIA Mouse Gene Index U043077, U336391
EC 6.3.2.-
Consensus CDS Project CCDS23861.1
International Mouse Phenotyping Consortium Status Ranbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified 
polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029000 Cyclophilin-like domain
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
InterPro IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
InterPro IPR022011 Nup358/RanBP2 E3 ligase domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR000156 Ran binding domain
InterPro IPR011990 Tetratricopeptide-like helical domain
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR001440 Tetratricopeptide repeat 1
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000013712 E3 SUMO-protein ligase RanBP2
Graphical View of Protein Domain Structure
References
(Earliest) J:33514 Wilken N, et al., Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995 Nov;68(3):211-9
(Latest) J:209507 Cho KI, et al., Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem. 2014 Feb 21;289(8):4600-25
All references(50)
Other
accession IDs
MGI:2143551, MGI:2443460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory