About   Help   FAQ
Ranbp2
Gene Detail
 Symbol
Name
ID
Ranbp2
RAN binding protein 2
MGI:894323
Synonyms A430087B05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
29.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:58446852-58494155 bp, + strand
From NCBI annotation of GRCm38

  47304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Ran-binding protein 2
Gene Tree: Ranbp2

Human
homologs
Human Homolog RANBP2, Ran binding protein 2
NCBI Gene ID 5903
neXtProt AC  NX_P49792
Human Synonyms  ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2
Human Chr (Location)  2q12.3; chr2:108719446-108785811 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RANBP2
Alleles
and
phenotypes
All alleles(18) : Targeted(5) Gene trapped(13)
 
Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process intracellular transport, mRNA transport, ...
Component membrane, mitochondrion, ...
Function ligase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (75)    Tissues (26)    Images (19)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 60
RT-PCR 15
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003226 (Evidence)
Entrez Gene19386 (Evidence)
DFCITC1574641, TC1589713, TC1615431, TC1663326, TC1663728, TC1690452
DoTSDT.101708068, DT.103567282, DT.110612682, DT.492970, DT.524631, DT.55233565, DT.91334332, DT.99851291
NIA Mouse Gene IndexU043077, U336391
EC6.3.2.-
Consensus CDS ProjectCCDS23861.1
International Mouse Knockout Project StatusRanbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified 
polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
InterPro IPR022011 Nup358/RanBP2 E3 ligase domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000156 Ran binding domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000013712 E3 SUMO-protein ligase RanBP2
Graphical View of Protein Domain Structure
References (Earliest) J:33514 Wilken N, et al., Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995 Nov;68(3):211-9
(Latest) J:199143 Cho KI, et al., Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors. PLoS Genet. 2013 Jun;9(6):e1003555
All references(47)
Other
accession IDs
MGI:2143551, MGI:2443460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory