Ranbp2
Gene Detail

Symbol Name ID

Ranbp2 RAN binding protein 2 MGI:894323

Synonyms

A430087B05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10

29.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:58446852-58494155 bp, + strand From NCBI annotation of GRCm38   47304 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Ran-binding protein 2
Gene Tree: Ranbp2

Human homologs

Human Homolog		RANBP2, Ran binding protein 2
NCBI Gene ID		5903
neXtProt AC		NX_P49792
Human Synonyms		ANE1, IIAE3, NUP358, TRP1, TRP2
Human Chr (Location)		2q12.3; chr2:109335937-109402267 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RANBP2

Alleles and phenotypes

All alleles(18) : Targeted(5) Gene trapped(13)
 

Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	intracellular transport, mRNA transport, ...
Component	nuclear inclusion body, nuclear membrane, ...
Function	isomerase activity, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (75)    Tissues (26)    Images (19)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	60
RT-PCR	15

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000003226 (Evidence)
Entrez Gene	19386 (Evidence)
DFCI	TC1574641, TC1589713, TC1615431, TC1663326, TC1663728, TC1690452
DoTS	DT.101708068, DT.103567282, DT.110612682, DT.492970, DT.524631, DT.55233565, DT.91334332, DT.99851291
NIA Mouse Gene Index	U043077, U336391
EC	6.3.2.-, 5.2.1.8
Consensus CDS Project	CCDS23861.1
International Mouse Knockout Project Status	Ranbp2

Sequences

Length	Strain/Species
genomic	19386	NCBI Gene Model | MGI Sequence Detail	47304	C57BL/6J
transcript	NM_011240	RefSeq | MGI Sequence Detail	9477	Not Specified
polypeptide	Q9ERU9	UniProt | EBI | MGI Sequence Detail	3053	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002130	Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
InterPro	IPR022011	Nup358/RanBP2 E3 ligase domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000156	Ran binding domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
InterPro	IPR001876	Zinc finger, RanBP2-type
Protein Ontology	PR:000013712	E3 SUMO-protein ligase RanBP2

Graphical View of Protein Domain Structure

References

(Earliest) J:33514 Wilken N, et al., Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995 Nov;68(3):211-9
(Latest) J:176959 Hamada M, et al., Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol. 2011 Aug 22;194(4):597-612
All references(47)

Other accession IDs

MGI:2143551, MGI:2443460