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Ranbp2 Gene Detail
Summary
  • Symbol
    Ranbp2
  • Name
    RAN binding protein 2
  • Synonyms
    A430087B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894323
    NCBI Gene: 19386
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:58446852-58494155 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47304 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 29.34 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RANBP2, RAN binding protein 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RANBP2, RAN binding protein 2
    Orthology source: HGNC
  • Synonyms
    ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2
  • Links
    NCBI Gene ID: 5903
    neXtProt AC: NX_P49792
    UniProt: P49792

  • Chr Location
    2q13; chr2:108719446-109842301 (+)  GRCh38.p7

  • Human Ortholog
    RGPD1, RANBP2-like and GRIP domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RanBP2L2, RGP1, RGPD2
  • Links
    NCBI Gene ID: 400966
    neXtProt AC: NX_P0DJD0
    UniProt: P0DJD0

  • Chr Location
    2p11.2; chr2:86913575-87013976 (+)  GRCh38.p7

  • Human Ortholog
    RGPD2, RANBP2-like and GRIP domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NUP358, RANBP2L2, RGP2
  • Links
    NCBI Gene ID: 729857
    neXtProt AC: NX_P0DJD1
    UniProt: P0DJD1

  • Chr Location
    2p11.2; chr2:87756955-87992819 (-)  GRCh38.p7

  • Human Ortholog
    RGPD3, RANBP2-like and GRIP domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGP3
  • Links
    NCBI Gene ID: 653489
    neXtProt AC: NX_A6NKT7
    UniProt: A6NKT7

  • Chr Location
    2q12.2; chr2:106404680-106470935 (-)  GRCh38.p7

  • Human Ortholog
    RGPD4, RANBP2-like and GRIP domain containing 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGP4
  • Links
    NCBI Gene ID: 285190
    neXtProt AC: NX_Q7Z3J3
    UniProt: Q7Z3J3

  • Chr Location
    2q12.3; chr2:107826921-107892544 (+)  GRCh38.p7

  • Human Ortholog
    RGPD5, RANBP2-like and GRIP domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BS63, BS-63, HEL161, RGP5
  • Links
    NCBI Gene ID: 84220
    neXtProt AC: NX_Q99666
    UniProt: Q99666

  • Chr Location
    2q13; chr2:109760592-109857691 (+)  GRCh38.p7

  • Human Ortholog
    RGPD6, RANBP2-like and GRIP domain containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RanBP2L1, RanBP2L2, RGP6, RGPD7
  • Links
    NCBI Gene ID: 729540
    neXtProt AC: NX_Q99666
    UniProt: Q99666

  • Chr Location
    2q13; chr2:110513802-110610903 (-)  GRCh38.p7

  • Human Ortholog
    RGPD8, RANBP2-like and GRIP domain containing 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RanBP2alpha, RANBP2L1, RGP8
  • Links
    NCBI Gene ID: 727851
    neXtProt AC: NX_O14715
    UniProt: O14715

  • Chr Location
    2q14.1; chr2:112368369-112433645 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
    transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified  
    polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      100 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
      IPR026054 Nuclear pore complex protein
      IPR037625 Nuclear pore complex protein Nup153
      IPR022011 Nup358/RanBP2 E3 ligase domain
      IPR011993 PH-like domain superfamily
      IPR000156 Ran binding domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
      IPR001876 Zinc finger, RanBP2-type
      IPR036443 Zinc finger, RanBP2-type superfamily
    Molecular
    Reagents
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    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143551, MGI:2443460
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:241665 Cho KI, et al., Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Dis Model Mech. 2017 May 01;10(5):559-579

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory