Ranbp2 MGI Mouse Gene Detail - MGI:894323

Symbol

Ranbp2
Name

RAN binding protein 2
Synonyms

A430087B05Rik

Feature Type

protein coding gene
IDs

MGI:894323
NCBI Gene: 19386
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:58282674-58329977 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.34 cM
Mapping Data

4 experiments

SNPs within 2kb

100 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894323	protein coding gene	Chr10:58282674-58330178 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017247	protein coding gene	Chr10:57549458-57601122 (+)
A/J	MGP_AJ_G0017224	protein coding gene	Chr10:55885195-55934805 (+)
AKR/J	MGP_AKRJ_G0017183	protein coding gene	Chr10:57341976-57389250 (+)
BALB/cJ	MGP_BALBcJ_G0017185	protein coding gene	Chr10:55972758-56020746 (+)
C3H/HeJ	MGP_C3HHeJ_G0017008	protein coding gene	Chr10:57259235-57308673 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017643	protein coding gene	Chr10:59646304-59697393 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015334	protein coding gene	Chr10:52995707-53045865 (+)
CAST/EiJ	MGP_CASTEiJ_G0016579	protein coding gene	Chr10:57169504-57235407 (+)
CBA/J	MGP_CBAJ_G0016980	protein coding gene	Chr10:61774138-61832769 (+)
DBA/2J	MGP_DBA2J_G0017085	protein coding gene	Chr10:55212475-55264939 (+)
FVB/NJ	MGP_FVBNJ_G0017079	protein coding gene	Chr10:54452411-54501117 (+)
LP/J	MGP_LPJ_G0017160	protein coding gene	Chr10:57939381-57994233 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017107	protein coding gene	Chr10:64343849-64393055 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017680	protein coding gene	Chr10:57151691-57202926 (+)
PWK/PhJ	MGP_PWKPhJ_G0016362	protein coding gene	Chr10:54991774-55042465 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016147	protein coding gene	Chr10:56520425-56570146 (+)
WSB/EiJ	MGP_WSBEiJ_G0016643	protein coding gene	Chr10:57053029-57100548 (+)

Human Ortholog

RANBP2, RAN binding protein 2

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RANBP2, RAN binding protein 2
Synonyms

ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2
Links

HGNC:9848

NCBI Gene ID: 5903

neXtProt AC: NX_P49792

UniProt: P49792
Chr Location

2q13; chr2:108719482-109842301 (+) GRCh38

Human Ortholog

RGPD1, RANBP2 like and GRIP domain containing 1
Synonyms

RanBP2L2, ranBP2L6, RGP1, RGPD2
Links

HGNC:32414

NCBI Gene ID: 400966

neXtProt AC: NX_P0DJD0

UniProt: P0DJD0
Chr Location

2p11.2; chr2:86913659-87013976 (+) GRCh38

Human Ortholog

RGPD2, RANBP2 like and GRIP domain containing 2
Synonyms

NUP358, RANBP2L2, RGP2
Links

HGNC:32415

NCBI Gene ID: 729857

neXtProt AC: NX_P0DJD1

UniProt: P0DJD1
Chr Location

2p11.2; chr2:87755960-87989818 (-) GRCh38

Human Ortholog

RGPD3, RANBP2 like and GRIP domain containing 3
Synonyms

RGP3
Links

HGNC:32416

NCBI Gene ID: 653489

neXtProt AC: NX_A6NKT7

UniProt: A6NKT7
Chr Location

2q12.2; chr2:106391290-106470935 (-) GRCh38

Human Ortholog

RGPD4, RANBP2 like and GRIP domain containing 4
Synonyms

RGP4
Links

HGNC:32417

NCBI Gene ID: 285190

neXtProt AC: NX_Q7Z3J3

UniProt: Q7Z3J3
Chr Location

2q12.3; chr2:107826892-107892544 (+) GRCh38

Human Ortholog

RGPD5, RANBP2 like and GRIP domain containing 5
Synonyms

BS63, BS-63, HEL161, RGP5
Links

HGNC:32418

NCBI Gene ID: 84220

neXtProt AC: NX_Q99666

UniProt: Q99666
Chr Location

2q13; chr2:109760618-109857705 (+) GRCh38

Human Ortholog

RGPD6, RANBP2 like and GRIP domain containing 6
Synonyms

RanBP2L1, RanBP2L2, RGP6, RGPD7
Links

HGNC:32419

NCBI Gene ID: 729540

neXtProt AC: NX_Q99666

UniProt: Q99666
Chr Location

2q13; chr2:110513802-110611056 (-) GRCh38

Human Ortholog

RGPD8, RANBP2 like and GRIP domain containing 8
Synonyms

RanBP2alpha, RANBP2L1, RGP8
Links

HGNC:9849

NCBI Gene ID: 727851

neXtProt AC: NX_O14715

UniProt: O14715
Chr Location

2q14.1

MGI Vertebrate Homology

Ranbp2 stringent orthology
8 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RANBP2, RGPD1, RGPD2, RGPD3, RGPD4, RGPD5, RGPD6, RGPD8
Gene Tree

Ranbp2

Diseases

2 with human RANBP2 associations

				Human Disease	Mouse Models
				brain disease IDs brain disease DOID:936 DOID:8510 ICD10CM:G93.40 ICD10CM:G93.9 ICD9CM:348.3 ICD9CM:348.30 ICD9CM:348.9 MESH:D001927 NCI:C26920 NCI:C96413 UMLS_CUI:C0006111 UMLS_CUI:C0085584
				inflammatory myofibroblastic tumor IDs inflammatory myofibroblastic tumor DOID:0050905

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

25 phenotypes from 4 alleles in 6 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Ranbp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

114 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.

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All GO Annotations

49
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

965
Tissues

85
cDNA Data

17
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ranbp2

ZFIN ranbp2

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS23861.1

Ensembl

ENSMUSG00000003226 (Evidence)
NCBI Gene

19386

			Length	Strain/Species	Flank
genomic	19386	NCBI Gene Model \| MGI Sequence Detail	47304	C57BL/6J	± kb
transcript	NM_011240	RefSeq \| MGI Sequence Detail	9477	Not Specified
polypeptide	Q9ERU9	UniProt \| EBI \| MGI Sequence Detail	3053	Not Applicable

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UniProt

3 Sequences
EC

2.3.2.-
InterPro Domains

IPR029000 Cyclophilin-like domain superfamily

IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain

IPR026054 Nuclear pore complex protein

IPR022011 Nup358/RanBP2 E3 ligase domain

IPR011993 PH-like domain superfamily

IPR000156 Ran binding domain

IPR045255 Ran binding protein RanBP1-like

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 4

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MGI:2143551, MGI:2443460

Summaries

All 79

Developmental Gene Expression 8

Gene Ontology 15

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:331499 Kragness S, et al., An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age. PLoS One. 2022;17(6):e0269404

TSS for Ranbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93446	Chr10:58282562-58282565 (+)	-110 bp
Tssr93447	Chr10:58282646-58282657 (+)	-22 bp
Tssr93448	Chr10:58282667-58282750 (+)	35 bp
Tssr93449	Chr10:58312144-58312159 (+)	29,478 bp
Tssr93450	Chr10:58314106-58314125 (+)	31,442 bp
Tssr93451	Chr10:58315845-58315872 (+)	33,185 bp
Tssr93452	Chr10:58319864-58319873 (+)	37,195 bp
Tssr93453	Chr10:58321575-58321586 (+)	38,907 bp
Tssr93454	Chr10:58321702-58321707 (+)	39,031 bp
Tssr93455	Chr10:58321811-58321825 (+)	39,144 bp
Tssr93456	Chr10:58328882-58328922 (+)	46,228 bp
Tssr93457	Chr10:58329591-58329642 (+)	46,943 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23