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Gene Detail

RAN binding protein 2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.34 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr10:58446852-58494155 bp, + strand
From NCBI annotation of GRCm38

  47304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:87808  Vertebrate Homology Class
7 human; 1 mouse; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ran-binding protein 2
Gene Tree: Ranbp2

Human Homolog   RGPD1, RANBP2-like and GRIP domain containing 1
NCBI Gene ID 400966
neXtProt AC  NX_P0DJD0
Human Synonyms  RanBP2L2, RGP1, RGPD2
Human Chr (Location)  2p11.2; chr2:86913573-87013976 (+)  GRCh38.p2
Human Homolog   RGPD2, RANBP2-like and GRIP domain containing 2
NCBI Gene ID 729857
neXtProt AC  NX_P0DJD1
Human Synonyms  NUP358, RANBP2L2, RGP2
Human Chr (Location)  2p11.2; chr2:87757198-87985814 (-)  GRCh38.p2
Human Homolog   RGPD3, RANBP2-like and GRIP domain containing 3
NCBI Gene ID 653489
neXtProt AC  NX_A6NKT7
Human Synonyms  RGP3
Human Chr (Location)  2q13; chr2:106391360-106468345 (-)  GRCh38.p2
Human Homolog   RGPD4, RANBP2-like and GRIP domain containing 4
NCBI Gene ID 285190
neXtProt AC  NX_Q7Z3J3
Human Synonyms  RGP4
Human Chr (Location)  2q12.3; chr2:107826932-107892544 (+)  GRCh38.p2
Human Homolog   RGPD5, RANBP2-like and GRIP domain containing 5
NCBI Gene ID 84220
neXtProt AC  NX_Q99666
Human Synonyms  BS63, BS-63, HEL161, RGP5
Human Chr (Location)  2q13; chr2:109760607-109857691 (+)  GRCh38.p2
Human Homolog   RGPD6, RANBP2-like and GRIP domain containing 6
NCBI Gene ID 729540
neXtProt AC  NX_Q99666
Human Synonyms  RanBP2L1, RanBP2L2, RGP6, RGPD7
Human Chr (Location)  2q13; chr2:110513802-110610888 (-)  GRCh38.p2
Human Homolog   RGPD8, RANBP2-like and GRIP domain containing 8
NCBI Gene ID 727851
neXtProt AC  NX_O14715
Human Synonyms  RanBP2alpha, RANBP2L1, RGP8
Human Chr (Location)  2q13; chr2:112368369-112433645 (-)  GRCh38.p2
alleles, and
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.
Ranbp2 interacts with 216 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
All GO classifications: (29 annotations)
Process intracellular transport, mRNA transport, ...
Component membrane, mitochondrion, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (75)    Tissues (26)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
Ensembl Gene ModelENSMUSG00000003226 (Evidence)
Entrez Gene19386 (Evidence)
DFCITC1690452, TC1663728, TC1574641, TC1663326, TC1615431, TC1589713
DoTSDT.492970, DT.110612682, DT.103567282, DT.101708068, DT.55233565, DT.524631, DT.91334332, DT.99851291
NIA Mouse Gene IndexU336391, U043077
Consensus CDS ProjectCCDS23861.1
International Mouse Knockout Project StatusRanbp2
Representative SequencesLengthStrain/SpeciesFlank
genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified 
polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
SNPs within 2kb(100 from dbSNP Build 137)
InterPro IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
InterPro IPR022011 Nup358/RanBP2 E3 ligase domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000156 Ran binding domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000013712 E3 SUMO-protein ligase RanBP2
Graphical View of Protein Domain Structure
(Earliest) J:33514 Wilken N, et al., Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995 Nov;68(3):211-9
(Latest) J:209507 Cho KI, et al., Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem. 2014 Feb 21;289(8):4600-25
All references(51)
accession IDs
MGI:2143551, MGI:2443460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory