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Rap1b Gene Detail
Summary
  • Symbol
    Rap1b
  • Name
    RAS related protein 1b
  • Synonyms
    2810443E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894315
    NCBI Gene: 215449
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117650502-117681879 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.32 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894315
protein coding gene Chr10:117649776-117681940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017764
protein coding gene Chr10:120780715-120813223 (-)
A/J MGP_AJ_G0017739
protein coding gene Chr10:116040281-116072221 (-)
AKR/J MGP_AKRJ_G0017703
protein coding gene Chr10:119440409-119471858 (-)
BALB/cJ MGP_BALBcJ_G0017703
protein coding gene Chr10:116438726-116475118 (-)
C3H/HeJ MGP_C3HHeJ_G0017528
protein coding gene Chr10:119676416-119707651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018158
protein coding gene Chr10:124920971-124953299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015839
protein coding gene Chr10:110606123-110637972 (-)
CAST/EiJ MGP_CASTEiJ_G0017088
protein coding gene Chr10:119971657-120003106 (-)
CBA/J MGP_CBAJ_G0017497
protein coding gene Chr10:129869485-129902701 (-)
DBA/2J MGP_DBA2J_G0017602
protein coding gene Chr10:115187435-115219361 (-)
FVB/NJ MGP_FVBNJ_G0017596
protein coding gene Chr10:114150928-114182549 (-)
LP/J MGP_LPJ_G0017675
protein coding gene Chr10:121317665-121349114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017626
protein coding gene Chr10:132689392-132720868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018198
protein coding gene Chr10:119513699-119547231 (-)
PWK/PhJ MGP_PWKPhJ_G0016872
protein coding gene Chr10:115288805-115320658 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016662
protein coding gene Chr10:118294363-118322495 (-)
WSB/EiJ MGP_WSBEiJ_G0017149
protein coding gene Chr10:119706501-119737886 (-)



Homology
more
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Synonyms
    K-REV, RAL1B
  • Links
    NCBI Gene ID: 5908
    neXtProt AC: NX_P61224
    UniProt: P61224

  • Chr Location
    12q15; chr12:68610839-68660605 (+)  GRCh38.p7

  • Human Ortholog
    RAP1BL, RAP1B like (pseudogene)
  • Links
    NCBI Gene ID: 643752
    UniProt: A6NIZ1

  • Chr Location
    5q13.3; chr5:76170085-76174354 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
    transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified  
    polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 32
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919983
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 46
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:322712 Lagarrigue F, et al., Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4(+) T Cells. J Immunol. 2022 Mar 15;208(6):1378-1388

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/09/2022
    MGI 6.21
    The Jackson Laboratory