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Rap1b
Gene Detail
 Symbol
Name
ID
Rap1b
RAS related protein 1b
MGI:894315
Synonyms 2810443E11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
66.32 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:117814597-117845974 bp, - strand
From NCBI annotation of GRCm38

  31378 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Rap1b

Human
homologs
Human Homolog RAP1B, RAP1B, member of RAS oncogene family
NCBI Gene ID 5908
neXtProt AC  NX_P61224
Human Synonyms  K-REV, RAL1B
Human Chr (Location)  12q14; chr12:68610839-68660605 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
 
Interactions
Rap1b interacts with 374 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell proliferation, cellular response to cAMP, ...
Component cell-cell junction, cell junction, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000052681 (Evidence)
Entrez Gene215449 (Evidence)
DFCITC1572119, TC1626560, TC1736484
DoTSDT.101393713, DT.101393721, DT.496250
NIA Mouse Gene IndexU080686
Consensus CDS ProjectCCDS24196.1
International Mouse Knockout Project StatusRap1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified 
polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013720 ras-related protein Rap-1b
Graphical View of Protein Domain Structure
References (Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:209591 Potla U, et al., Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr 1;124(4):1757-69
All references(52)
Other
accession IDs
MGI:1919983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory