About   Help   FAQ
Rap1b
Gene Detail
Symbol

Name
ID
Rap1b
RAS related protein 1b
MGI:894315
Synonyms
2810443E11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
66.32 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:117814597-117845974 bp, - strand
From NCBI annotation of GRCm38

  31378 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAP1B
Protein SuperFamily: ras protein
Gene Tree: Rap1b

Human
homologs
RAP1B, RAP1B, member of RAS oncogene family
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5908
neXtProt AC: NX_P61224

Human Synonyms: K-REV, RAL1B

Human Chr (Location): 12q14; chr12:68610839-68660605 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
 
Interactions
Rap1b interacts with 374 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell proliferation, cellular response to cAMP, ...
Component cell-cell junction, cell junction, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rap1b ; ZFIN rap1b    NEW 
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000052681 (Evidence)
Entrez Gene 215449 (Evidence)
DFCI TC1572119, TC1736484, TC1626560
DoTS DT.496250, DT.101393721, DT.101393713
NIA Mouse Gene Index U080686
Consensus CDS Project CCDS24196.1
International Mouse Phenotyping Consortium Status Rap1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified 
polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013720 ras-related protein Rap-1b
Graphical View of Protein Domain Structure
References
(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:218107 Kumar S, et al., The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. J Exp Med. 2014 Aug 25;211(9):1741-58
All references(52)
Other
accession IDs
MGI:1919983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory