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Rap1b Gene Detail
Summary
  • Symbol
    Rap1b
  • Name
    RAS related protein 1b
  • Synonyms
    2810443E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894315
    NCBI Gene: 215449
  • Gene Overview
    MyGene.info: RAP1B
Location & Maps
more
  • Sequence Map
    Chr10:117814597-117845974 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31378 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.32 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K-REV, RAL1B
  • Links
    NCBI Gene ID: 5908
    neXtProt AC: NX_P61224

  • Chr Location
    12q14; chr12:68610839-68660605 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Targeted
    3
  • Genomic Mutations
    1 involving Rap1b
  • Incidental Mutations
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified  
polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013720 ras-related protein Rap-1b
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 31
    cDNA 31

    Microarray probesets 5
Other
Accession IDs
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MGI:1919983
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
  • Latest
    J:228314 Ishihara S, et al., Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis. Nat Commun. 2015;6:8982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory