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Rap1b Gene Detail
Summary
  • Symbol
    Rap1b
  • Name
    RAS related protein 1b
  • Synonyms
    2810443E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894315
    NCBI Gene: 215449
  • Gene Overview
    MyGene.info: RAP1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:117814597-117845974 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31378 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.32 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K-REV, RAL1B
  • Links
    NCBI Gene ID: 5908
    neXtProt AC: NX_P61224
    UniProt: P61224

  • Chr Location
    12q15; chr12:68610839-68660605 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
    transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified  
    polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      148 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001806 Small GTPase superfamily
      IPR020849 Small GTPase superfamily, Ras-type
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919983
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:244369 Kondo N, et al., NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization. Mol Cell Biol. 2017 Apr 15;37(8):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory