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Sept8 Gene Detail
Summary
  • Symbol
    Sept8
  • Name
    septin 8
  • Synonyms
    mKIAA0202, Sepl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894310
    NCBI Gene: 20362
  • Gene Overview
    MyGene.info: SEPTIN8
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53519736-53549603 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894310
protein coding gene Chr11:53519257-53549603 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018298
protein coding gene Chr11:52908003-52941029 (+)
A/J MGP_AJ_G0018267
protein coding gene Chr11:50920523-50950053 (+)
AKR/J MGP_AKRJ_G0018237
protein coding gene Chr11:52586250-52615756 (+)
BALB/cJ MGP_BALBcJ_G0018238
protein coding gene Chr11:51278450-51307986 (+)
C3H/HeJ MGP_C3HHeJ_G0018049
protein coding gene Chr11:52551569-52580908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018690
protein coding gene Chr11:54502581-54534143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016340
protein coding gene Chr11:48465871-48496305 (+)
CAST/EiJ MGP_CASTEiJ_G0017614
protein coding gene Chr11:52601186-52636472 (+)
CBA/J MGP_CBAJ_G0018024
protein coding gene Chr11:57082027-57119013 (+)
DBA/2J MGP_DBA2J_G0018134
protein coding gene Chr11:50668532-50697933 (+)
FVB/NJ MGP_FVBNJ_G0018126
protein coding gene Chr11:50309957-50340668 (+)
LP/J MGP_LPJ_G0018208
protein coding gene Chr11:53357234-53386632 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018150
protein coding gene Chr11:58407949-58439332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018732
protein coding gene Chr11:52612400-52642308 (+)
PWK/PhJ MGP_PWKPhJ_G0017389
protein coding gene Chr11:51191459-51221911 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017184
protein coding gene Chr11:52434804-52464220 (+)
WSB/EiJ MGP_WSBEiJ_G0017661
protein coding gene Chr11:52254716-52284708 (+)



Homology
more
  • Human Ortholog
    SEPTIN8, septin 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEPTIN8, septin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SEP2, SEPT8
  • Links
    NCBI Gene ID: 23176
    neXtProt AC: NX_Q92599
    UniProt: Q92599

  • Chr Location
    5q31.1; chr5:132750817-132778216 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit myelin outfoldings and reduced nerve conduction velocity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20362 NCBI Gene Model | MGI Sequence Detail 29868 C57BL/6J ±  kb
    transcript NM_033144 RefSeq | MGI Sequence Detail 4647 C57BL/6  
    polypeptide Q8CHH9 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      Genomic 5
      cDNA 120
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144480
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246510 Kurkinen KM, et al., SEPT8 modulates beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016 Jun 01;129(11):2224-38

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory