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Acsl6 Gene Detail
Summary
  • Symbol
    Acsl6
  • Name
    acyl-CoA synthetase long-chain family member 6
  • Synonyms
    A330035H04Rik, Facl6, Lacsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894291
    NCBI Gene: 216739
  • Gene Overview
    MyGene.info: ACSL6
Location & Maps
more
  • Sequence Map
    Chr11:54303798-54364756 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      60959 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ACSL6, acyl-CoA synthetase long-chain family member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACSL6, acyl-CoA synthetase long-chain family member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACS2, FACL6, LACS2, LACS5, LACS 6
  • Links
    NCBI Gene ID: 23305
    neXtProt AC: NX_Q9UKU0

  • Chr Location
    5q31.1; chr5:131949973-132012068 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Acsl6
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    270
  • Tissues
    111
  • cDNA Data
    11
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005668 VEGA Gene Model | MGI Sequence Detail 60959 C57BL/6J ±  kb
transcript OTTMUST00000012610 VEGA | MGI Sequence Detail 2594 Not Applicable  
polypeptide OTTMUSP00000005837 VEGA | MGI Sequence Detail 722 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    534 from dbSNP Build 142
Protein
Information
less
  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000003663 long-chain-fatty-acid--CoA ligase 6
  • EC
    6.2.1.3
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR025110 AMP-binding enzyme C-terminal domain
    IPR000873 AMP-dependent synthetase/ligase
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2144490, MGI:2444956
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:40314 Frazer KA, et al., Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. Genome Res. 1997 May;7(5):495-512
  • Latest
    J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory