Acsl6 MGI Mouse Gene Detail - MGI:894291 - acyl-CoA synthetase long-chain family member 6

Symbol

Acsl6
Name

acyl-CoA synthetase long-chain family member 6
Synonyms

A330035H04Rik, Facl6, Lacsl

Feature Type

protein coding gene
IDs

MGI:894291
NCBI Gene: 216739
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:54194624-54255582 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

4 experiments

SNPs within 2kb

534 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894291	protein coding gene	Chr11:54194580-54255582 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018314	protein coding gene	Chr11:53776013-53836563 (+)
A/J	MGP_AJ_G0018283	protein coding gene	Chr11:51766984-51828238 (+)
AKR/J	MGP_AKRJ_G0018252	protein coding gene	Chr11:53462965-53530002 (+)
BALB/cJ	MGP_BALBcJ_G0018254	protein coding gene	Chr11:52110733-52172451 (+)
C3H/HeJ	MGP_C3HHeJ_G0018065	protein coding gene	Chr11:53400148-53471780 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018706	protein coding gene	Chr11:55428010-55494155 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016356	protein coding gene	Chr11:49229794-49290466 (+)
CAST/EiJ	MGP_CASTEiJ_G0017630	protein coding gene	Chr11:53446862-53506781 (+)
CBA/J	MGP_CBAJ_G0018040	protein coding gene	Chr11:58066300-58126892 (+)
DBA/2J	MGP_DBA2J_G0018149	protein coding gene	Chr11:51480545-51541653 (+)
FVB/NJ	MGP_FVBNJ_G0018141	protein coding gene	Chr11:51124078-51184444 (+)
LP/J	MGP_LPJ_G0018224	protein coding gene	Chr11:54224366-54289101 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018167	protein coding gene	Chr11:59265274-59327340 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018748	protein coding gene	Chr11:53481799-53542178 (+)
PWK/PhJ	MGP_PWKPhJ_G0017403	protein coding gene	Chr11:52023030-52085369 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017198	protein coding gene	Chr11:53257180-53323924 (+)
WSB/EiJ	MGP_WSBEiJ_G0017678	protein coding gene	Chr11:53109377-53174379 (+)

Human Ortholog

ACSL6, acyl-CoA synthetase long chain family member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSL6, acyl-CoA synthetase long chain family member 6
Synonyms

ACS2, FACL6, LACS2, LACS5, LACS 6
Links

HGNC:16496

NCBI Gene ID: 23305

neXtProt AC: NX_Q9UKU0

UniProt: Q9UKU0
Chr Location

5q31.1; chr5:131949973-132012068 (-) GRCh38.p7

Alliance of Genome Resources

Acsl6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACSL6
Gene Tree

Acsl6

Diseases

2 with human ACSL6 associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				leukemia IDs leukemia DOID:1240 DOID:9145 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 UMLS_CUI:C0023418

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 2 alleles in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving Acsl6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Knockout mice show altered or impaired lipogenesis and amino acid and nucleotide metabolism in the brain as well as changes to coordination and startle reflex.

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All GO Annotations

36
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

976
Tissues

111
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acsl6

ZFIN acsl6

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Acsl6 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

122
RefSeq

34
UniProt

15
CCDS

CCDS24694.1, CCDS24695.1, CCDS24696.1, CCDS24697.1

Ensembl

ENSMUSG00000020333 (Evidence)
NCBI Gene

216739

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020333	Ensembl Gene Model \| MGI Sequence Detail	60959	C57BL/6J	± kb
transcript	ENSMUST00000108904	Ensembl \| MGI Sequence Detail	2594	Not Applicable
polypeptide	ENSMUSP00000104532	Ensembl \| MGI Sequence Detail	722	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000003663 long-chain-fatty-acid--CoA ligase 6

(term hierarchy)
EC

6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR000873 AMP-dependent synthetase/ligase

IPR042099 ANL, N-terminal domain

IPR045311 Long-chain fatty acid CoA synthetase, eukaryotic

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All nucleic 17

Genomic 2

cDNA 12

Primer pair 2

Other 1

Microarray probesets 6

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MGI:2144490, MGI:2444956

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 7
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:325774 Fernandez RF, et al., Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. JCI Insight. 2021 Jun 8;6(11)

TSS for Acsl6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101480	Chr11:54194628-54194670 (+)	25 bp
Tssr101481	Chr11:54194874-54194885 (+)	256 bp
Tssr101482	Chr11:54194965-54194983 (+)	350 bp
Tssr101483	Chr11:54195006-54195062 (+)	410 bp
Tssr101484	Chr11:54195074-54195085 (+)	456 bp
Tssr101485	Chr11:54205754-54205783 (+)	11,145 bp
Tssr101486	Chr11:54205786-54205825 (+)	11,182 bp
Tssr101487	Chr11:54205855-54205864 (+)	11,236 bp
Tssr101488	Chr11:54217852-54217859 (+)	23,232 bp
Tssr101489	Chr11:54217870-54217879 (+)	23,251 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 11/22/2022 MGI 6.22