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Acsl6 Gene Detail
Summary
  • Symbol
    Acsl6
  • Name
    acyl-CoA synthetase long-chain family member 6
  • Synonyms
    A330035H04Rik, Facl6, Lacsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894291
    NCBI Gene: 216739
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54194624-54255582 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1689 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894291
 protein coding gene Chr11:54194580-54255582 (+)
129S1/SvImJ ENSMUSG00200039794
 protein coding gene Chr11:51191525-51251888 (+)
A/J ENSMUSG00195031953
 protein coding gene Chr11:51128856-51189209 (+)
AKR/J ENSMUSG00220036967
 protein coding gene Chr11:51317364-51377948 (+)
BALB/cJ ENSMUSG00180041372
 protein coding gene Chr11:51193556-51254113 (+)
C3H/HeJ ENSMUSG00175035490
 protein coding gene Chr11:51160101-51220470 (+)
C57BL/6NJ ENSMUSG00215020291
 protein coding gene Chr11:50982506-51043066 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016356
 protein coding gene Chr11:49229794-49290466 (+)
CAST/EiJ ENSTCUG00005039433
 protein coding gene Chr11:50756465-50816702 (+)
CBA/J ENSMUSG00210028631
 protein coding gene Chr11:51015968-51076342 (+)
DBA/2J ENSMUSG00185043360
 protein coding gene Chr11:51228939-51289522 (+)
FVB/NJ ENSMUSG00205034052
 protein coding gene Chr11:51058420-51118791 (+)
JF1/MsJ ENSUMUG00000034620
 protein coding gene Chr11:51605960-51667339 (+)
LP/J ENSMUSG00230048489
 protein coding gene Chr11:52409127-52469491 (+)
NOD/ShiLtJ ENSMUSG00190042917
 protein coding gene Chr11:51279536-51339963 (+)
NZO/HlLtJ ENSMUSG00225032399
 protein coding gene Chr11:54458615-54519982 (+)
PWK/PhJ ENSLUMG00010031463
 protein coding gene Chr11:51054703-51114975 (+)
SPRET/EiJ ENSMSPG00010029237
 protein coding gene Chr11:51751830-51812496 (+)
WSB/EiJ ENSIUOG00005038669
 protein coding gene Chr11:51066366-51126952 (+)



Homology
more
  • Human Ortholog
    ACSL6, acyl-CoA synthetase long chain family member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACSL6, acyl-CoA synthetase long chain family member 6
  • Synonyms
    ACS2, FACL6, LACS2, LACS5, LACS 6
  • Links
    NCBI Gene ID: 23305
    UniProt: Q9UKU0

  • Chr Location
    5q31.1; chr5:131949973-132012243 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ACSL6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice show altered or impaired lipogenesis and amino acid and nucleotide metabolism in the brain as well as changes to coordination and startle reflex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    112
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020333 Ensembl Gene Model | MGI Sequence Detail 60959 C57BL/6J ±  kb
    transcript ENSMUST00000108904 Ensembl | MGI Sequence Detail 2594 Not Applicable  
    polypeptide ENSMUSP00000104532 Ensembl | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144490, MGI:2444956
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:367126 Wang Y, et al., Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes. Commun Biol. 2024 Aug 21;7(1):1027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory