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P4ha2 Gene Detail
Summary
  • Symbol
    P4ha2
  • Name
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
  • Synonyms
    P4hl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894286
    NCBI Gene: 18452
  • Gene Overview
    MyGene.info: P4HA2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54100924-54131668 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.13 cM, cytoband A5-B1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894286
protein coding gene Chr11:54100095-54131668 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018311
protein coding gene Chr11:53565193-53596737 (+)
A/J MGP_AJ_G0018280
protein coding gene Chr11:51560427-51595383 (+)
AKR/J MGP_AKRJ_G0018249
protein coding gene Chr11:53252553-53285568 (+)
BALB/cJ MGP_BALBcJ_G0018251
protein coding gene Chr11:51901393-51936082 (+)
C3H/HeJ MGP_C3HHeJ_G0018062
protein coding gene Chr11:53192385-53224550 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018703
protein coding gene Chr11:55212561-55245999 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016353
protein coding gene Chr11:49028476-49059655 (+)
CAST/EiJ MGP_CASTEiJ_G0017627
protein coding gene Chr11:53239620-53270263 (+)
CBA/J MGP_CBAJ_G0018037
protein coding gene Chr11:57832119-57866388 (+)
DBA/2J MGP_DBA2J_G0018146
protein coding gene Chr11:51279127-51310733 (+)
FVB/NJ MGP_FVBNJ_G0018138
protein coding gene Chr11:50920977-50952494 (+)
LP/J MGP_LPJ_G0018221
protein coding gene Chr11:54013488-54044765 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018164
protein coding gene Chr11:59054895-59087247 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018745
protein coding gene Chr11:53267041-53304230 (+)
PWK/PhJ MGP_PWKPhJ_G0017400
protein coding gene Chr11:51818066-51849215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017195
protein coding gene Chr11:53030385-53062913 (+)
WSB/EiJ MGP_WSBEiJ_G0017675
protein coding gene Chr11:52901570-52933631 (+)



Homology
more
  • Human Ortholog
    P4HA2, prolyl 4-hydroxylase subunit alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    P4HA2, prolyl 4-hydroxylase subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYP25
  • Links
    NCBI Gene ID: 8974
    neXtProt AC: NX_O15460
    UniProt: O15460

  • Chr Location
    5q31.1; chr5:132190147-132227863 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18452 NCBI Gene Model | MGI Sequence Detail 30745 C57BL/6J ±  kb
transcript NM_011031 RefSeq | MGI Sequence Detail 2284 C57BL/6  
polypeptide Q60716 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    Genomic 3
    cDNA 71
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143965, MGI:2144619
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:270507 Funato N, et al., Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Arch Oral Biol. 2018 Nov;95:149-155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory