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P4ha2 Gene Detail
Summary
  • Symbol
    P4ha2
  • Name
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
  • Synonyms
    P4hl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894286
    NCBI Gene: 18452
  • Gene Overview
    MyGene.info: P4HA2
Location & Maps
more
  • Sequence Map
    Chr11:54100095-54131665 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31571 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.13 cM, cytoband A5-B1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    P4HA2, prolyl 4-hydroxylase subunit alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    P4HA2, prolyl 4-hydroxylase subunit alpha 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8974
    neXtProt AC: NX_O15460

  • Chr Location
    5q31; chr5:132192009-132227863 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving P4ha2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005665 VEGA Gene Model | MGI Sequence Detail 31571 C57BL/6J ±  kb
transcript OTTMUST00000012599 VEGA | MGI Sequence Detail 2230 Not Applicable  
polypeptide OTTMUSP00000005833 VEGA | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    269 from dbSNP Build 142
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000012197 prolyl 4-hydroxylase subunit alpha-2
  • EC
  • InterPro Domains
    IPR005123 Oxoglutarate/iron-dependent dioxygenase
    IPR006620 Prolyl 4-hydroxylase, alpha subunit
    IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 75
    Genomic 3
    cDNA 70
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2143965, MGI:2144619
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:25202 Helaakoski T, et al., Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4427-31
  • Latest
    J:222764 Aro E, et al., Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I. J Biol Chem. 2015 Jul 3;290(27):16964-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory