Rab12
Gene Detail

Symbol

Name
ID

Rab12
RAB12, member RAS oncogene family
MGI:894284

Synonyms

2900054P15Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17
37.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:66494512-66519717 bp, - strand From VEGA annotation of GRCm38   25206 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:103879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab12

Human
homologs

Human Homolog		RAB12, RAB12, member RAS oncogene family
NCBI Gene ID		201475
neXtProt AC		NX_Q6IQ22
Human Chr (Location)		18p11.22; chr18:8609445-8639383 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(11)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Rab12 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (29 annotations)

Process	autophagy, cellular protein catabolic process, ...
Component	autophagic vacuole, cell, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(68) cDNA(67) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000021023 (Evidence)
Ensembl Gene Model	ENSMUSG00000023460 (Evidence)
Entrez Gene	19328 (Evidence)
UniGene	248313
DFCI	TC1583087, TC1599203, TC1610918, TC1606616
DoTS	DT.101364950, DT.101254766, DT.534599
NIA Mouse Gene Index	U038018
Consensus CDS Project	CCDS50169.1
International Mouse Knockout Project Status	Rab12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021023	VEGA Gene Model | MGI Sequence Detail	25206	C57BL/6J
transcript	OTTMUST00000049704	VEGA | MGI Sequence Detail	2057	Not Applicable
polypeptide	OTTMUSP00000023081	VEGA | MGI Sequence Detail	291	Not Applicable

All sequences(48) RefSeq(7) UniProt(2)

Polymorphisms

SNPs within 2kb(5 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000014380	ras-related protein Rab-12

References

(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:211234 Sirohi K, et al., M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013 Apr;9(4):510-27
All references(39)

Other
accession IDs

MGI:1920280, MGI:2147089, MGI:2147118