Rab12 Gene Detail

Summary

• Symbol
  Rab12
• Name
  RAB12, member RAS oncogene family
• Synonyms
  2900054P15Rik

• Feature Type
  protein coding gene
• IDs
  MGI:894284
  NCBI Gene: 19328

Location & Maps

• Sequence Map
  Chr17:66494512-66519717 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    25206 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 37.88 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  RAB12, RAB12, member RAS oncogene family

• Vertebrate Orthologs
  10

• Human Ortholog
  RAB12, RAB12, member RAS oncogene family
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:31332

  NCBI Gene ID: 201475

  neXtProt AC: NX_Q6IQ22

  UniProt: Q6IQ22

  
  
• Chr Location
  18p11.22; chr18:8609428-8639383 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 103879
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: RAB12
• Protein SuperFamily
  Ras-related protein Rab
• Gene Tree
  Rab12
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  12
• Endonuclease-mediated
  1
• Gene trapped
  11
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  15 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  7

• External Resources
  FuncBase

Expression

• cDNA Data
  68

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rab12
  ZFIN rab12

Interactions

• Rab12 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  7
• UniProt
  2
• CCDS
  CCDS50169.1
• UniGene
  248313

• VEGA
  OTTMUSG00000021023 (Evidence)
• Ensembl
  ENSMUSG00000023460 (Evidence)
• NCBI Gene
  19328

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000021023	VEGA Gene Model | MGI Sequence Detail	25206	C57BL/6J
transcript	OTTMUST00000049704	VEGA | MGI Sequence Detail	2057	Not Applicable
polypeptide	OTTMUSP00000023081	VEGA | MGI Sequence Detail	291	Not Applicable

Polymorphisms

• SNPs within 2kb
  5 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000014380 ras-related protein Rab-12
  (term hierarchy)
• InterPro Domains
  IPR027417 P-loop containing nucleoside triphosphate hydrolase
  IPR001806 Small GTPase superfamily
  IPR005225 Small GTP-binding protein domain

Molecular
Reagents

• All nucleic 69

  cDNA 68

  Other 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1920280, MGI:2147089, MGI:2147118

References

• Summaries
  All 35

  Gene Ontology 7

  Phenotypes 5
• Earliest
  J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
• Latest
  J:211234 Sirohi K, et al., M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013 Apr;9(4):510-27