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Rab12
Gene Detail
Symbol

Name
ID
Rab12
RAB12, member RAS oncogene family
MGI:894284
Synonyms
2900054P15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
37.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:66494512-66519717 bp, - strand
From VEGA annotation of GRCm38

  25206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:103879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB12
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab12

Human
homologs
RAB12, RAB12, member RAS oncogene family
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 201475
neXtProt AC: NX_Q6IQ22

Human Chr (Location): 18p11.22; chr18:8609445-8639383 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Rab12 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process autophagy, cellular protein catabolic process, ...
Component autophagosome, cell, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab12 ; ZFIN rab12    NEW 
Molecular
reagents
All nucleic(69) cDNA(68) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021023 (Evidence)
Ensembl Gene Model ENSMUSG00000023460 (Evidence)
Entrez Gene 19328 (Evidence)
UniGene 248313
DFCI TC1583087, TC1599203, TC1606616, TC1610918
DoTS DT.101254766, DT.101364950, DT.534599
NIA Mouse Gene Index U038018
Consensus CDS Project CCDS50169.1
International Mouse Phenotyping Consortium Status Rab12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021023 VEGA Gene Model | MGI Sequence Detail 25206 C57BL/6J ±  kb
transcript OTTMUST00000049704 VEGA | MGI Sequence Detail 2057 Not Applicable 
polypeptide OTTMUSP00000023081 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014380 ras-related protein Rab-12
References
(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:211234 Sirohi K, et al., M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013 Apr;9(4):510-27
All references(37)
Other
accession IDs
MGI:1920280, MGI:2147089, MGI:2147118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory