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Rab12 Gene Detail
Summary
  • Symbol
    Rab12
  • Name
    RAB12, member RAS oncogene family
  • Synonyms
    2900054P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894284
    NCBI Gene: 19328
Location & Maps
more
  • Sequence Map
    Chr17:66494512-66519717 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      25206 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 37.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAB12, RAB12, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB12, RAB12, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 201475
    neXtProt AC: NX_Q6IQ22

  • Chr Location
    18p11.22; chr18:8609445-8639383 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    12
  • Endonuclease-mediated
    1
  • Gene trapped
    11
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    68
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021023 VEGA Gene Model | MGI Sequence Detail 25206 C57BL/6J ±  kb
transcript OTTMUST00000049704 VEGA | MGI Sequence Detail 2057 Not Applicable  
polypeptide OTTMUSP00000023081 VEGA | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014380 ras-related protein Rab-12
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 69
    cDNA 68
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920280, MGI:2147089, MGI:2147118
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
  • Latest
    J:211234 Sirohi K, et al., M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013 Apr;9(4):510-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory