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Rab12 Gene Detail
Summary
  • Symbol
    Rab12
  • Name
    RAB12, member RAS oncogene family
  • Synonyms
    2900054P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894284
    NCBI Gene: 19328
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66494512-66519729 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 37.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894284
 protein coding gene Chr17:66494512-66519750 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023988
 protein coding gene Chr17:68715890-68742273 (-)
A/J MGP_AJ_G0023946
 protein coding gene Chr17:66636183-66661394 (-)
AKR/J MGP_AKRJ_G0023915
 protein coding gene Chr17:67583256-67608457 (-)
BALB/cJ MGP_BALBcJ_G0023947
 protein coding gene Chr17:66588721-66613777 (-)
C3H/HeJ MGP_C3HHeJ_G0023711
 protein coding gene Chr17:68455781-68480995 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024393
 protein coding gene Chr17:71340311-71368835 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021839
 protein coding gene Chr17:62640438-62665819 (-)
CAST/EiJ MGP_CASTEiJ_G0023193
 protein coding gene Chr17:68827601-68852573 (-)
CBA/J MGP_CBAJ_G0023687
 protein coding gene Chr17:74143791-74168943 (-)
DBA/2J MGP_DBA2J_G0023815
 protein coding gene Chr17:65371187-65396369 (-)
FVB/NJ MGP_FVBNJ_G0023781
 protein coding gene Chr17:64868756-64894832 (-)
LP/J MGP_LPJ_G0023897
 protein coding gene Chr17:69423678-69449890 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023809
 protein coding gene Chr17:74217882-74245616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024437
 protein coding gene Chr17:68011282-68037811 (-)
PWK/PhJ MGP_PWKPhJ_G0022939
 protein coding gene Chr17:64665778-64691737 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022750
 protein coding gene Chr17:64720992-64745841 (-)
WSB/EiJ MGP_WSBEiJ_G0023259
 protein coding gene Chr17:68755315-68780413 (-)



Homology
more
  • Human Ortholog
    RAB12, RAB12, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB12, RAB12, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 201475
    neXtProt AC: NX_Q6IQ22
    UniProt: Q6IQ22

  • Chr Location
    18p11.22; chr18:8609428-8639383 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • cDNA Data
    69
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023460 Ensembl Gene Model | MGI Sequence Detail 25218 C57BL/6J ±  kb
transcript ENSMUST00000070538 Ensembl | MGI Sequence Detail 2069 Not Applicable  
polypeptide ENSMUSP00000070134 Ensembl | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920280, MGI:2147089, MGI:2147118
References
more
  • Summaries
    All 37
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
  • Latest
    J:211234 Sirohi K, et al., M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013 Apr;9(4):510-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/05/2021
MGI 6.16 		The Jackson Laboratory