About   Help   FAQ
Bche Gene Detail
Summary
  • Symbol
    Bche
  • Name
    butyrylcholinesterase
  • Synonyms
    C730038G20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894278
    NCBI Gene: 12038
  • Gene Overview
    MyGene.info: BCHE
Location & Maps
more
  • Sequence Map
    Chr3:73635808-73708415 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72608 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 33.61 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BCHE, butyrylcholinesterase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCHE, butyrylcholinesterase
    Orthology source: HomoloGene
  • Synonyms
    CHE1, CHE2, E1
  • Links
    NCBI Gene ID: 590
    neXtProt AC: NX_P06276

  • Chr Location
    3q26.1-q26.2; chr3:165772904-165837472 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Bche mouse models; 1 with human BCHE associations

Human Disease Mouse Models
       Butyrylcholinesterase; BCHE   OMIM: 177400 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    2 involving Bche
  • Incidental Mutations
Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026601 VEGA Gene Model | MGI Sequence Detail 72608 C57BL/6J ±  kb
transcript OTTMUST00000065820 VEGA | MGI Sequence Detail 6210 Not Applicable  
polypeptide OTTMUSP00000032857 VEGA | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    312 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2445138
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:41300 Rachinsky TL, et al., Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Neuron. 1990 Sep;5(3):317-27
  • Latest
    J:227529 Maurice T, et al., Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse. Behav Brain Res. 2016 Jan 1;296:351-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory