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Bche
Gene Detail
Symbol

Name
ID
Bche
butyrylcholinesterase
MGI:894278
Synonyms
C730038G20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
33.61 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:73635808-73708415 bp, - strand
From VEGA annotation of GRCm38

  72608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: BCHE
Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Bche

Human
homologs
BCHE, butyrylcholinesterase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 590
neXtProt AC: NX_P06276

Human Synonyms: CHE1, CHE2, E1

Human Chr (Location): 3q26.1-q26.2; chr3:165772904-165837472 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities.
 
Human Diseases Modeled in Mice Using Bche (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Bche interacts with 411 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process choline metabolic process, learning, ...
Component blood microparticle, endoplasmic reticulum, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bche    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000026601 (Evidence)
Ensembl Gene Model ENSMUSG00000027792 (Evidence)
Entrez Gene 12038 (Evidence)
DoTS DT.40183821, DT.91290694
NIA Mouse Gene Index U024155
EC 3.1.1.-, 3.1.1.8
Consensus CDS Project CCDS17411.1
International Mouse Phenotyping Consortium Status Bche
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026601 VEGA Gene Model | MGI Sequence Detail 72608 C57BL/6J ±  kb
transcript OTTMUST00000065820 VEGA | MGI Sequence Detail 6210 Not Applicable 
polypeptide OTTMUSP00000032857 VEGA | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014788 Acetylcholinesterase, tetramerisation domain
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000997 Cholinesterase
Protein Ontology PR:000004685 cholinesterase
References
(Earliest) J:41300 Rachinsky TL, et al., Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Neuron. 1990 Sep;5(3):317-27
(Latest) J:220003 Chen VP, et al., Plasma butyrylcholinesterase regulates ghrelin to control aggression. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2251-6
All references(37)
Disease annotation references (1)
Other
accession IDs
MGI:2445138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory