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Bche
Gene Detail
Symbol

Name
ID
Bche
butyrylcholinesterase
MGI:894278
Synonyms
C730038G20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
33.61 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:73635808-73708415 bp, - strand
From VEGA annotation of GRCm38

  72608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Bche

Human
homologs
Human Homolog BCHE, butyrylcholinesterase
NCBI Gene ID 590
neXtProt AC  NX_P06276
Human Synonyms  CHE1, CHE2, E1
Human Chr (Location)  3q26.1-q26.2; chr3:165772904-165837472 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human BCHE
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities.
 
Human Diseases Modeled Using Mouse Bche (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Bche interacts with 411 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process choline metabolic process, learning, ...
Component blood microparticle, endoplasmic reticulum, ...
Function acetylcholinesterase activity, carboxylic ester hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026601 (Evidence)
Ensembl Gene ModelENSMUSG00000027792 (Evidence)
Entrez Gene12038 (Evidence)
DoTSDT.40183821, DT.91290694
NIA Mouse Gene IndexU024155
EC3.1.1.8
Consensus CDS ProjectCCDS17411.1
International Mouse Knockout Project StatusBche
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026601 VEGA Gene Model | MGI Sequence Detail 72608 C57BL/6J ±  kb
transcript OTTMUST00000065820 VEGA | MGI Sequence Detail 6210 Not Applicable 
polypeptide OTTMUSP00000032857 VEGA | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014788 Acetylcholinesterase, tetramerisation
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000997 Cholinesterase
Protein Ontology PR:000004685 cholinesterase
References
(Earliest) J:41300 Rachinsky TL, et al., Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Neuron. 1990 Sep;5(3):317-27
(Latest) J:196424 Reid GA, et al., Butyrylcholinesterase and the cholinergic system. Neuroscience. 2013 Mar 27;234:53-68
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:2445138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory