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Rfng Gene Detail
Summary
  • Symbol
    Rfng
  • Name
    RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    radical fringe
  • Feature Type
    protein coding gene
  • IDs
    MGI:894275
    NCBI Gene: 19719
Location & Maps
more
  • Sequence Map
    Chr11:120780746-120784207 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3462 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RFNG, RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RFNG, RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5986
    neXtProt AC: NX_Q9Y644

  • Chr Location
    17q25; chr17:82047902-82051774 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display a completely normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004135 VEGA Gene Model | MGI Sequence Detail 3462 C57BL/6J ±  kb
transcript OTTMUST00000009330 VEGA | MGI Sequence Detail 2118 Not Applicable  
polypeptide OTTMUSP00000004540 VEGA | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 50
    cDNA 48
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 48
    Developmental Gene Expression 21
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
  • Latest
    J:213069 Vanorny DA, et al., Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol. 2014 Apr;28(4):499-511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory