Frg1
Gene Detail

Symbol Name ID

Frg1 FSHD region gene 1 MGI:893597

Feature Type

protein coding gene

Genetic Map

Chromosome 8

23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:41397457-41417118 bp, - strand From Ensembl annotation of GRCm38   19662 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3295  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Frg1

Human homologs

Human Homolog		FRG1, FSHD region gene 1
NCBI Gene ID		2483
neXtProt AC		NX_Q14331
Human Synonyms		FRG1A, FSG1
Human Chr (Location)		4q35; chr4:190861974-190884359 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FRG1

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	mRNA processing, ribosome biogenesis, ...
Component	catalytic step 2 spliceosome, nucleus, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (11)    Tissues (6)   
Theiler Stages: 28

Assay Type	Results
Northern blot	11

cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(74) Genomic(7) cDNA(64) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031590 (Evidence)
Entrez Gene	14300 (Evidence)
UniGene	217312
DFCI	TC1578329
DoTS	DT.87069143
NIA Mouse Gene Index	U029761
PDB	2YUG
Consensus CDS Project	CCDS22263.1
International Mouse Knockout Project Status	Frg1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031590	Ensembl Gene Model | MGI Sequence Detail	19662	C57BL/6J
transcript	ENSMUST00000033999	Ensembl | MGI Sequence Detail	1085	Not Applicable
polypeptide	ENSMUSP00000033999	Ensembl | MGI Sequence Detail	258	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

PCR(2) : SNPs(157 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008999	Actin cross-linking
InterPro	IPR010414	FRG1-like
Protein Ontology	PR:000007660	protein FRG1

References

(Earliest) J:40667 Grewal PK, et al., The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal to the myodystrophy mutation on chromosome 8. Mamm Genome. 1997 Jun;8(6):394-8
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(30)