About   Help   FAQ
Frg1
Gene Detail
Symbol

Name
ID
Frg1
FSHD region gene 1
MGI:893597
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:41397457-41417118 bp, - strand
From Ensembl annotation of GRCm38

  19662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3295  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FRG1
Gene Tree: Frg1

Human
homologs
FRG1, FSHD region gene 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2483
neXtProt AC: NX_Q14331

Human Synonyms: FRG1A, FSG1

Human Chr (Location): 4q35; chr4:189940819-189963204 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FRG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(2) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
Mutations Annotated to Human Diseases (2)   
Interactions
Frg1 interacts with 35 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process mRNA processing, muscle organ development, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function actin binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (11)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 11
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase frg1 ; ZFIN frg1    NEW 
Molecular
reagents
All nucleic(74) Genomic(7) cDNA(64) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031590 (Evidence)
Entrez Gene 14300 (Evidence)
UniGene 217312
DFCI TC1578329
DoTS DT.87069143
NIA Mouse Gene Index U029761
PDB 2YUG
Consensus CDS Project CCDS22263.1
International Mouse Phenotyping Consortium Status Frg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031590 Ensembl Gene Model | MGI Sequence Detail 19662 C57BL/6J ±  kb
transcript ENSMUST00000033999 Ensembl | MGI Sequence Detail 1085 Not Applicable 
polypeptide ENSMUSP00000033999 Ensembl | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
PCR(2) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008999 Actin cross-linking
InterPro IPR010414 FRG1-like
Protein Ontology PR:000007660 protein FRG1
References
(Earliest) J:40667 Grewal PK, et al., The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal to the myodystrophy mutation on chromosome 8. Mamm Genome. 1997 Jun;8(6):394-8
(Latest) J:208283 Sancisi V, et al., Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD region gene 1 (FRG1). Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15;306(2):R124-37
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory