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Frg1 Gene Detail
Summary
  • Symbol
    Frg1
  • Name
    FSHD region gene 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:893597
    NCBI Gene: 14300
  • Gene Overview
    MyGene.info: FRG1
Location & Maps
more
  • Sequence Map
    Chr8:41397457-41417118 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19662 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FRG1, FSHD region gene 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FRG1, FSHD region gene 1
    Orthology source: HomoloGene
  • Synonyms
    FRG1A, FSG1
  • Links
    NCBI Gene ID: 2483
    neXtProt AC: NX_Q14331

  • Chr Location
    4q35; chr4:189940819-189963204 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3295
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FRG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FRG1 associations

Human Disease Mouse Models
       Facioscapulohumeral Muscular Dystrophy 1; FSHD1   OMIM: 158900 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    2
  • Transgenic
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031590 Ensembl Gene Model | MGI Sequence Detail 19662 C57BL/6J ±  kb
transcript ENSMUST00000033999 Ensembl | MGI Sequence Detail 1085 Not Applicable  
polypeptide ENSMUSP00000033999 Ensembl | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    318 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    Genomic 7
    cDNA 64
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Diseases 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:40667 Grewal PK, et al., The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal to the myodystrophy mutation on chromosome 8. Mamm Genome. 1997 Jun;8(6):394-8
  • Latest
    J:208283 Sancisi V, et al., Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD region gene 1 (FRG1). Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15;306(2):R124-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory