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Cirbp
Gene Detail
Symbol

Name
ID
Cirbp
cold inducible RNA binding protein
MGI:893588
Synonyms
Cirp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:80165985-80172786 bp, + strand
From VEGA annotation of GRCm38

  6802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cirbp

Human
homologs
Human Homolog CIRBP, cold inducible RNA binding protein
NCBI Gene ID 1153
neXtProt AC  NX_Q14011
Human Synonyms  CIRP
Human Chr (Location)  19p13.3; chr19:1269266-1274810 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(54) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit impaired spermatogonia proliferation.
 
Interactions
Cirbp interacts with 118 markers (Mir7-1, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process mRNA stabilization, negative regulation of translation, ...
Component cytoplasm, cytoplasmic stress granule, ...
Function mRNA 3'-UTR binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (30)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
RT-PCR 2
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000003 (Evidence)
Ensembl Gene ModelENSMUSG00000045193 (Evidence)
Entrez Gene12696 (Evidence)
UniGene17898
DFCITC1574810
DoTSDT.493329
NIA Mouse Gene IndexU011741
Consensus CDS ProjectCCDS35975.1
International Mouse Knockout Project StatusCirbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000003 VEGA Gene Model | MGI Sequence Detail 6802 C57BL/6J ±  kb
transcript OTTMUST00000045723 VEGA | MGI Sequence Detail 1321 Not Applicable 
polypeptide OTTMUSP00000020590 VEGA | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000005499 cold-inducible RNA-binding protein
References
(Earliest) J:40491 Nishiyama H, et al., A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J Cell Biol. 1997 May 19;137(4):899-908
(Latest) J:213039 Lopez M, et al., Tumor necrosis factor and transforming growth factor beta regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). J Biol Chem. 2014 Jan 31;289(5):2736-44
All references(45)
Other
accession IDs
MGI:2143957

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory