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Dok1
Gene Detail
 Symbol
Name
ID
Dok1
docking protein 1
MGI:893587
Synonyms p62DOK
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:83030934-83033471 bp, - strand
From VEGA annotation of GRCm38

  2538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Dok1

Human
homologs
Human Homolog DOK1, docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Gene ID 1796
neXtProt AC  NX_Q99704
Human Synonyms  P62DOK
Human Chr (Location)  2p13; chr2:74549020-74557551 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display mild abnormalities in myeloid cell proliferation.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Dok1 interacts with 52 markers (Mir23b, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intracellular signal transduction, MAPK cascade, ...
Component cytoplasm, intracellular, ...
Function insulin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(42) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023337 (Evidence)
Ensembl Gene ModelENSMUSG00000068335 (Evidence)
Entrez Gene13448 (Evidence)
UniGene156
DFCITC1578757
DoTSDT.489779, DT.99858390
NIA Mouse Gene IndexU027515
PDB1P5T, 1UEF
Consensus CDS ProjectCCDS20265.1
International Mouse Knockout Project StatusDok1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023337 VEGA Gene Model | MGI Sequence Detail 2538 C57BL/6J ±  kb
transcript OTTMUST00000056545 VEGA | MGI Sequence Detail 1807 Not Applicable 
polypeptide OTTMUSP00000027191 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006628 docking protein 1
References (Earliest) J:40721 Yamanashi Y, et al., Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell. 1997 Jan 24;88(2):205-11
(Latest) J:187941 Besin G, et al., Dok-1 overexpression promotes development of gammadelta natural killer T cells. Eur J Immunol. 2012 Sep;42(9):2491-504
All references(55)
Other
accession IDs
MGI:2141708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory