Dok1
Gene Detail

Symbol Name ID

Dok1 docking protein 1 MGI:893587

Synonyms

p62DOK

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:83030934-83033471 bp, - strand From VEGA annotation of GRCm38   2538 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dok1

Human homologs

Human Homolog		DOK1, docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Gene ID		1796
neXtProt AC		NX_Q99704
Human Synonyms		P62DOK
Human Chr (Location)		2p13; chr2:74776147-74784678 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous null mice display mild abnormalities in myeloid cell proliferation.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	intracellular protein kinase cascade, MAPK cascade, ...
Component	cytoplasm
Function	insulin receptor binding, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(4) cDNA(41) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023337 (Evidence)
Ensembl Gene Model	ENSMUSG00000068335 (Evidence)
Entrez Gene	13448 (Evidence)
UniGene	156
DFCI	TC1578757
DoTS	DT.489779, DT.99858390
NIA Mouse Gene Index	U027515
PDB	1P5T, 1UEF
Consensus CDS Project	CCDS20265.1
International Mouse Knockout Project Status	Dok1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023337	VEGA Gene Model | MGI Sequence Detail	2538	C57BL/6J
transcript	OTTMUST00000056545	VEGA | MGI Sequence Detail	1807	Not Applicable
polypeptide	OTTMUSP00000027191	VEGA | MGI Sequence Detail	482	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs within 2kb(54 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002404	Insulin receptor substrate-1, PTB
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000006628	docking protein 1

References

(Earliest) J:40721 Yamanashi Y, et al., Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell. 1997 Jan 24;88(2):205-11
(Latest) J:187941 Besin G, et al., Dok-1 overexpression promotes development of gammadelta natural killer T cells. Eur J Immunol. 2012 Sep;42(9):2491-504
All references(55)

Other accession IDs

MGI:2141708