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Dok1
Gene Detail
Symbol

Name
ID
Dok1
docking protein 1
MGI:893587
Synonyms
p62DOK
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:83030934-83033471 bp, - strand
From VEGA annotation of GRCm38

  2538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DOK1
Gene Tree: Dok1

Human
homologs
DOK1, docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1796
neXtProt AC: NX_Q99704

Human Synonyms: P62DOK

Human Chr (Location): 2p13; chr2:74548205-74557551 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(1) Targeted(4)
Genomic Mutations involving Dok1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display mild abnormalities in myeloid cell proliferation.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Dok1 interacts with 52 markers (Mir23b, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intracellular signal transduction, MAPK cascade, ...
Component cytoplasm, intracellular, ...
Function insulin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dok1    NEW 
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(42) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023337 (Evidence)
Ensembl Gene Model ENSMUSG00000068335 (Evidence)
Entrez Gene 13448 (Evidence)
UniGene 156
DFCI TC1578757
DoTS DT.489779, DT.99858390
NIA Mouse Gene Index U027515
PDB 1P5T, 1UEF
Consensus CDS Project CCDS20265.1
International Mouse Phenotyping Consortium Status Dok1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023337 VEGA Gene Model | MGI Sequence Detail 2538 C57BL/6J ±  kb
transcript OTTMUST00000056545 VEGA | MGI Sequence Detail 1807 Not Applicable 
polypeptide OTTMUSP00000027191 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 IRS-type PTB domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000006628 docking protein 1
References
(Earliest) J:40721 Yamanashi Y, et al., Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell. 1997 Jan 24;88(2):205-11
(Latest) J:214849 Celis-Gutierrez J, et al., Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014 Sep 1;33(17):1928-40
All references(56)
Other
accession IDs
MGI:2141708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory