Gngt2 MGI Mouse Gene Detail - MGI:893584 - guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Symbol

Gngt2
Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Feature Type

protein coding gene
IDs

MGI:893584
NCBI Gene: 14710
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr11:95733045-95736557 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

4 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893584	protein coding gene	Chr11:95728042-95736560 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018991	protein coding gene	Chr11:98076151-98084667 (+)
A/J	MGP_AJ_G0018959	protein coding gene	Chr11:94106883-94115383 (+)
AKR/J	MGP_AKRJ_G0018929	protein coding gene	Chr11:97009792-97018286 (+)
BALB/cJ	MGP_BALBcJ_G0018932	protein coding gene	Chr11:94587195-94595729 (+)
C3H/HeJ	MGP_C3HHeJ_G0018746	protein coding gene	Chr11:97141545-97150057 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019384	protein coding gene	Chr11:101146436-101154958 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017014	protein coding gene	Chr11:91582539-91590974 (+)
CAST/EiJ	MGP_CASTEiJ_G0018300	protein coding gene	Chr11:97957571-97966176 (+)
CBA/J	MGP_CBAJ_G0018717	protein coding gene	Chr11:105279483-105287993 (+)
DBA/2J	MGP_DBA2J_G0018825	protein coding gene	Chr11:93680860-93689446 (+)
FVB/NJ	MGP_FVBNJ_G0018814	protein coding gene	Chr11:93153656-93163314 (+)
LP/J	MGP_LPJ_G0018895	protein coding gene	Chr11:98641871-98650414 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018841	protein coding gene	Chr11:105300339-105308873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019424	protein coding gene	Chr11:97299444-97308034 (+)
PWK/PhJ	MGP_PWKPhJ_G0018071	protein coding gene	Chr11:94621592-94630171 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017860	protein coding gene	Chr11:96994371-97002929 (+)
WSB/EiJ	MGP_WSBEiJ_G0018349	protein coding gene	Chr11:97209618-97218145 (+)

Human Ortholog

GNGT2, G protein subunit gamma transducin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNGT2, G protein subunit gamma transducin 2
Synonyms

G-GAMMA-8, G-GAMMA-C, GNG9, GNGT8, HG3I
Links

HGNC:4412

NCBI Gene ID: 2793

UniProt: O14610
Chr Location

17q21.32; chr17:49202791-49210574 (-) GRCh38

MGI Vertebrate Homology

Gngt2 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: GNGT2
Gene Tree

Gngt2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

4
Targeted

6
Genomic Mutations

2 involving Gngt2
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

6
cDNA Data

22
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gngt2

ZFIN gngt2a, gngt2b

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All Sequences

63
RefSeq

12
UniProt

3
CCDS

CCDS25284.1

Ensembl

ENSMUSG00000038811 (Evidence)
NCBI Gene

14710

			Length	Strain/Species	Flank
genomic	14710	NCBI Gene Model \| MGI Sequence Detail	3513	C57BL/6J	± kb
transcript	NM_001284393	RefSeq \| MGI Sequence Detail	590	Not Specified
polypeptide	Q61017	UniProt \| EBI \| MGI Sequence Detail	69	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008114 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

(term hierarchy)
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR001770 G-protein, gamma subunit

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All nucleic 33

Genomic 6

cDNA 24

Primer pair 3

Microarray probesets 3

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MGI:2144460

Summaries

All 52

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 17
Earliest

J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
Latest

J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518

TSS for Gngt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104400	Chr11:95733056-95733067 (+)	17 bp
Tssr104401	Chr11:95733074-95733096 (+)	40 bp
Tssr104402	Chr11:95733109-95733133 (+)	76 bp
Tssr104403	Chr11:95733160-95733171 (+)	121 bp
Tssr104404	Chr11:95733494-95733530 (+)	467 bp
Tssr104405	Chr11:95733532-95733547 (+)	495 bp
Tssr104406	Chr11:95733550-95733565 (+)	513 bp
Tssr104407	Chr11:95733968-95733984 (+)	931 bp
Tssr104408	Chr11:95734052-95734065 (+)	1,014 bp
Tssr104409	Chr11:95734419-95734455 (+)	1,392 bp
Tssr104410	Chr11:95734460-95734470 (+)	1,420 bp
Tssr104411	Chr11:95734472-95734515 (+)	1,449 bp
Tssr104412	Chr11:95734630-95734649 (+)	1,595 bp
Tssr104413	Chr11:95734662-95734682 (+)	1,627 bp
Tssr104414	Chr11:95734692-95734701 (+)	1,652 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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