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Prtn3
Gene Detail
Symbol

Name
ID
Prtn3
proteinase 3
MGI:893580
Synonyms
mPR3, myeloblastin, PR3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:79874476-79883174 bp, + strand
From VEGA annotation of GRCm38

  8699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:120934  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 western clawed frog

HCOP human homology predictions: PRTN3
Protein SuperFamily: trypsin
Gene Tree: Prtn3

Human
homologs
PRTN3, proteinase 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5657
neXtProt AC: NX_P24158

Human Synonyms: ACPA, AGP7, CANCA, C-ANCA, MBN, MBT, NP4, NP-4, P29, PR3, PR-3

Human Chr (Location): 19p13.3; chr19:840965-848175 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Genomic Mutations involving Prtn3 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prtn3 interacts with 30 markers (Mir135a-1, Mir136, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process collagen catabolic process, mature conventional dendritic cell differentiation, ...
Component cytosol, extracellular exosome, ...
Function enzyme binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 4
RT-PCR 5
cDNA source data(27)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase prtn3    NEW 
Molecular
reagents
All nucleic(34) Genomic(3) cDNA(28) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035169 (Evidence)
Ensembl Gene Model ENSMUSG00000057729 (Evidence)
Entrez Gene 19152 (Evidence)
UniGene 2364
DFCI TC1582575
DoTS DT.491651
NIA Mouse Gene Index U011727
EC 3.4.21.76
Consensus CDS Project CCDS23993.1
International Mouse Phenotyping Consortium Status Prtn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035169 VEGA Gene Model | MGI Sequence Detail 8699 C57BL/6J ±  kb
transcript OTTMUST00000089581 VEGA | MGI Sequence Detail 1025 Not Applicable 
polypeptide OTTMUSP00000048978 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013333 myeloblastin
References
(Earliest) J:40592 Jenne DE, et al., Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis. FEBS Lett. 1997 May 19;408(2):187-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory