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Prtn3 Gene Detail
Summary
  • Symbol
    Prtn3
  • Name
    proteinase 3
  • Synonyms
    mPR3, myeloblastin, PR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:893580
    NCBI Gene: 19152
  • Gene Overview
    MyGene.info: PRTN3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79879667-79883174 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893580
protein coding gene Chr10:79874476-79883174 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017465
protein coding gene Chr10:80429625-80443070 (+)
A/J MGP_AJ_G0017443
protein coding gene Chr10:77629670-77638364 (+)
AKR/J MGP_AKRJ_G0017404
protein coding gene Chr10:79743540-79752236 (+)
BALB/cJ MGP_BALBcJ_G0017405
protein coding gene Chr10:77855751-77864449 (+)
C3H/HeJ MGP_C3HHeJ_G0017228
protein coding gene Chr10:79847444-79858175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017859
protein coding gene Chr10:83206584-83218547 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015547
protein coding gene Chr10:73855922-73864881 (+)
CAST/EiJ MGP_CASTEiJ_G0016795
protein coding gene Chr10:80033951-80043048 (+)
CBA/J MGP_CBAJ_G0017200
protein coding gene Chr10:86436029-86444727 (+)
DBA/2J MGP_DBA2J_G0017306
protein coding gene Chr10:76844505-76853267 (+)
FVB/NJ MGP_FVBNJ_G0017300
protein coding gene Chr10:76021911-76030609 (+)
LP/J MGP_LPJ_G0017377
protein coding gene Chr10:80909847-80918580 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017326
protein coding gene Chr10:88408756-88417477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017900
protein coding gene Chr10:79730809-79739507 (+)
PWK/PhJ MGP_PWKPhJ_G0016576
protein coding gene Chr10:76706096-76715629 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016365
protein coding gene Chr10:78702634-78711507 (+)
WSB/EiJ MGP_WSBEiJ_G0016855
protein coding gene Chr10:79751416-79760319 (+)



Homology
more
  • Human Ortholog
    PRTN3, proteinase 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRTN3, proteinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACPA, AGP7, CANCA, C-ANCA, MBN, MBT, NP4, NP-4, P29, PR3, PR-3
  • Links
    NCBI Gene ID: 5657
    neXtProt AC: NX_P24158
    UniProt: P24158

  • Chr Location
    19p13.3; chr19:840965-848175 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed neutrophil death and increased neutrophil accumulation at sites of inflammation in a murine model of peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19152 NCBI Gene Model | MGI Sequence Detail 3508 C57BL/6J ±  kb
transcript NM_011178 RefSeq | MGI Sequence Detail 983 129/Sv  
polypeptide Q61096 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 32
    Genomic 3
    cDNA 28
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:237236 Qi X, et al., Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016 Sep 19;213(10):2081-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory