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Prtn3 Gene Detail
Summary
  • Symbol
    Prtn3
  • Name
    proteinase 3
  • Synonyms
    mPR3, myeloblastin, PR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:893580
    NCBI Gene: 19152
  • Gene Overview
    MyGene.info: PRTN3
Location & Maps
more
  • Sequence Map
    Chr10:79874476-79883174 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8699 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRTN3, proteinase 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRTN3, proteinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACPA, AGP7, CANCA, C-ANCA, MBN, MBT, NP4, NP-4, P29, PR3, PR-3
  • Links
    NCBI Gene ID: 5657
    neXtProt AC: NX_P24158

  • Chr Location
    19p13.3; chr19:840965-848175 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    6
  • Genomic Mutations
    2 involving Prtn3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035169 VEGA Gene Model | MGI Sequence Detail 8699 C57BL/6J ±  kb
transcript OTTMUST00000089581 VEGA | MGI Sequence Detail 1025 Not Applicable  
polypeptide OTTMUSP00000048978 VEGA | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 34
    Genomic 3
    cDNA 28
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:40592 Jenne DE, et al., Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis. FEBS Lett. 1997 May 19;408(2):187-90
  • Latest
    J:227486 Millet A, et al., Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. J Clin Invest. 2015 Nov 2;125(11):4107-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory