Prtn3
Gene Detail

Symbol Name ID

Prtn3 proteinase 3 MGI:893580

Synonyms

mPR3, myeloblastin, PR3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:79874476-79883174 bp, + strand From VEGA annotation of GRCm38   8699 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle

Protein SuperFamily: trypsin
Gene Tree: Prtn3

Human homologs

Human Homolog		PRTN3, proteinase 3
NCBI Gene ID		5657
neXtProt AC		NX_P24158
Human Synonyms		ACPA, AGP7, CANCA, C-ANCA, MBN, MBT, NP4, NP-4, P29, PR3, PR-3
Human Chr (Location)		19p13.3; chr19:840985-848175 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	collagen catabolic process, mature dendritic cell differentiation, ...
Component	cytosol, extracellular matrix, ...
Function	catalytic activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (11)   
Theiler Stages: 2, 3, 4, 5, 26

Assay Type	Results
Northern blot	4
RT-PCR	10

cDNA source data(27)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(3) cDNA(28) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035169 (Evidence)
Ensembl Gene Model	ENSMUSG00000057729 (Evidence)
Entrez Gene	19152 (Evidence)
UniGene	2364
DFCI	TC1582575
DoTS	DT.491651
NIA Mouse Gene Index	U011727
EC	3.4.21.76
Consensus CDS Project	CCDS23993.1
International Mouse Knockout Project Status	Prtn3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035169	VEGA Gene Model | MGI Sequence Detail	8699	C57BL/6J
transcript	OTTMUST00000089581	VEGA | MGI Sequence Detail	1025	Not Applicable
polypeptide	OTTMUSP00000048978	VEGA | MGI Sequence Detail	254	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000013333	myeloblastin

References

(Earliest) J:37575 Lutzelschwab C, et al., Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. J Exp Med. 1997 Jan 6;185(1):13-29
(Latest) J:187789 Mankan AK, et al., The NLRP3/ASC/Caspase-1 axis regulates IL-1beta processing in neutrophils. Eur J Immunol. 2012 Mar;42(3):710-5
All references(46)