Prtn3 MGI Mouse Gene Detail - MGI:893580

Symbol

Prtn3
Name

proteinase 3
Synonyms

mPR3, myeloblastin, PR3

Feature Type

protein coding gene
IDs

MGI:893580
NCBI Gene: 19152
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:79715499-79719008 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

4 experiments

SNPs within 2kb

133 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893580	protein coding gene	Chr10:79710310-79719008 (+)
129S1/SvImJ	ENSMUSG00200049005	protein coding gene	Chr10:76333558-76342677 (+)
A/J	ENSMUSG00195038598	protein coding gene	Chr10:76729047-76738168 (+)
AKR/J	ENSMUSG00220042177	protein coding gene	Chr10:76326607-76335736 (+)
BALB/cJ	ENSMUSG00180045791	protein coding gene	Chr10:76739529-76748654 (+)
C3H/HeJ	ENSMUSG00175051739	protein coding gene	Chr10:76610262-76619391 (+)
C57BL/6NJ	ENSMUSG00215051007	protein coding gene	Chr10:76351958-76361083 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015547	protein coding gene	Chr10:73855922-73864881 (+)
CAST/EiJ	ENSTCUG00005050224	protein coding gene	Chr10:76236608-76245839 (+)
CBA/J	ENSMUSG00210047255	protein coding gene	Chr10:76466350-76475475 (+)
DBA/2J	ENSMUSG00185047407	protein coding gene	Chr10:76808729-76817854 (+)
FVB/NJ	ENSMUSG00205046250	protein coding gene	Chr10:76521516-76530643 (+)
JF1/MsJ	ENSUMUG00000044125	protein coding gene	Chr10:78039054-78048202 (+)
LP/J	ENSMUSG00230045258	protein coding gene	Chr10:78578474-78587599 (+)
NOD/ShiLtJ	ENSMUSG00190047910	protein coding gene	Chr10:76722481-76731606 (+)
NZO/HlLtJ	ENSMUSG00225050389	protein coding gene	Chr10:82864835-82873960 (+)
PWK/PhJ	ENSLUMG00010042989	protein coding gene	Chr10:76398547-76407722 (+)
SPRET/EiJ	ENSMSPG00010037128	protein coding gene	Chr10:78025040-78028587 (+)
WSB/EiJ	ENSIUOG00005050493	protein coding gene	Chr10:76426588-76435719 (+)

Human Ortholog

PRTN3, proteinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRTN3, proteinase 3
Synonyms

ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3
Links

HGNC:9495

NCBI Gene ID: 5657

UniProt: P24158
Chr Location

19p13.3; chr19:840999-848175 (+) GRCh38

MGI Vertebrate Homology

Prtn3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRTN3
Gene Tree

Prtn3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Targeted

9
Genomic Mutations

3 involving Prtn3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit delayed neutrophil death and increased neutrophil accumulation at sites of inflammation in a murine model of peritonitis.

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All GO Annotations

36
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

606
Tissues

6
cDNA Data

27
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prtn3

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All Sequences

42
RefSeq

2
UniProt

5
CCDS

CCDS23993.1

Ensembl

ENSMUSG00000057729 (Evidence)
NCBI Gene

19152

			Length	Strain/Species	Flank
genomic	19152	NCBI Gene Model \| MGI Sequence Detail	3510	C57BL/6J	± kb
transcript	NM_011178	RefSeq \| MGI Sequence Detail	974	ZRU/MplStud
polypeptide	Q61096	UniProt \| EBI \| MGI Sequence Detail	254	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013333 myeloblastin

(term hierarchy)
EC

3.4.21.1, 3.4.21.76
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR050850 Peptidase S1 family, Elastase subfamily

IPR009003 Peptidase S1, PA clan

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR001254 Serine proteases, trypsin domain

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

Q61096 2 sites

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All nucleic 32

Genomic 3

cDNA 28

Primer pair 1

Microarray probesets 3

Summaries

All 72

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:371810 Kline SN, et al., Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march. Cell Rep. 2025 Aug 26;44(8):116054

TSS for Prtn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94418	Chr10:79715491-79715503 (+)	-2 bp
Tssr94419	Chr10:79716814-79716854 (+)	1,335 bp
Tssr94420	Chr10:79716857-79716871 (+)	1,365 bp
Tssr94421	Chr10:79716879-79716893 (+)	1,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24