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Khdrbs1
Gene Detail
 Symbol
Name
ID
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
MGI:893579
Synonyms p62, Sam68
Feature Type protein coding gene
Genetic Map
Chromosome 4
63.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:129703164-129742303 bp, - strand
From VEGA annotation of GRCm38

  39140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4781  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Khdrbs1

Human
homologs
Human Homolog KHDRBS1, KH domain containing, RNA binding, signal transduction associated 1
NCBI Gene ID 10657
neXtProt AC  NX_Q07666
Human Synonyms  p62, p68, Sam68
Human Chr (Location)  1p32; chr1:32013694-32060859 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene protects mice from age-related bone loss and the formation of fatty bone marrow. Males are infertile and females do not care for young. Some die at birth.
 
Phenotype Images(3)
Interactions
Khdrbs1 interacts with 390 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell cycle, cell surface receptor signaling pathway, ...
Component cytoplasm, Grb2-Sos complex, ...
Function poly(A) binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (78)    Tissues (66)    Images (36)
Theiler Stages: 1, 2, 3, 4, 5, 14, 15, 17, 19, 21, 27, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 49
Western blot 7
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000009514 (Evidence)
Ensembl Gene ModelENSMUSG00000028790 (Evidence)
Entrez Gene20218 (Evidence)
DFCITC1576051, TC1588941, TC1600806, TC1611470
DoTSDT.101398762, DT.110795602, DT.110795604, DT.495537, DT.91381978, DT.94409417, DT.99861380
NIA Mouse Gene IndexU025568
Consensus CDS ProjectCCDS18703.1
International Mouse Knockout Project StatusKhdrbs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009514 VEGA Gene Model | MGI Sequence Detail 39140 C57BL/6J ±  kb
transcript OTTMUST00000021746 VEGA | MGI Sequence Detail 2600 Not Applicable 
polypeptide OTTMUSP00000034966 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(5) UniProt(1)
Polymorphisms SNPs within 2kb(453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
Protein Ontology PR:000009279 KH domain-containing, RNA-binding, signal transduction-associated protein 1
References (Earliest) J:26499 Agger R, et al., Purification and cDNA sequence of a murine protein homologous to the human p62 tyrosine phosphoprotein that associates with the Ras GTPase-activating protein p120 GAP. Gene. 1995 Jun 9;158(2):307-8
(Latest) J:208331 Iijima T, et al., Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1. J Cell Biol. 2014 Feb 3;204(3):331-42
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory