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Stx4a Gene Detail
Summary
  • Symbol
    Stx4a
  • Name
    syntaxin 4A (placental)
  • Synonyms
    Stx4, Syn4, Syn-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:893577
    NCBI Gene: 20909
  • Gene Overview
    MyGene.info: STX4
Location & Maps
more
  • Sequence Map
    Chr7:127824294-127849019 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24726 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.77 cM, cytoband F4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    STX4, syntaxin 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STX4, syntaxin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p35-2, STX4A
  • Links
    NCBI Gene ID: 6810
    neXtProt AC: NX_Q12846

  • Chr Location
    16p11.2; chr16:31033095-31040168 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    3
  • Targeted
    4
  • Incidental Mutations
    APF
Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030969 VEGA Gene Model | MGI Sequence Detail 24726 C57BL/6J ±  kb
transcript OTTMUST00000076681 VEGA | MGI Sequence Detail 1456 Not Applicable  
polypeptide OTTMUSP00000040409 VEGA | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Gene Ontology 20
    Phenotypes 8
  • Earliest
    J:38990 Tellam JT, et al., Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86
  • Latest
    J:228090 Thurmond DC, et al., Potential Site Effects and Transgene Expression Discrepancies in Mouse Lifespan Studies. Cell Metab. 2015 Sep 1;22(3):346-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory