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Stx4a
Gene Detail
 Symbol
Name
ID
Stx4a
syntaxin 4A (placental)
MGI:893577
Synonyms Stx4, Syn4, Syn-4
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.77 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:127824294-127849019 bp, + strand
From VEGA annotation of GRCm38

  24726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx4a

Human
homologs
Human Homolog STX4, syntaxin 4
NCBI Gene ID 6810
neXtProt AC  NX_Q12846
Human Synonyms  p35-2, STX4A
Human Chr (Location)  16p11.2; chr16:31033095-31040168 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.
 
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process intracellular protein transport, membrane fusion, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding, Rab GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 29
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(52) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030969 (Evidence)
Ensembl Gene ModelENSMUSG00000030805 (Evidence)
Entrez Gene20909 (Evidence)
UniGene24867
DFCITC1580713, TC1595271
DoTSDT.101382539, DT.488732
NIA Mouse Gene IndexU008819
PDB3PUJ, 3PUK
Consensus CDS ProjectCCDS21880.1
International Mouse Knockout Project StatusStx4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030969 VEGA Gene Model | MGI Sequence Detail 24726 C57BL/6J ±  kb
transcript OTTMUST00000076681 VEGA | MGI Sequence Detail 1456 Not Applicable 
polypeptide OTTMUSP00000040409 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015796 syntaxin-4
References (Earliest) J:38990 Tellam JT, et al., Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86
(Latest) J:197846 Jurado S, et al., LTP requires a unique postsynaptic SNARE fusion machinery. Neuron. 2013 Feb 6;77(3):542-58
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory