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Stx4a
Gene Detail
Symbol

Name
ID
Stx4a
syntaxin 4A (placental)
MGI:893577
Synonyms
Stx4, Syn4, Syn-4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.77 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:127824294-127849019 bp, + strand
From VEGA annotation of GRCm38

  24726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: STX4
Protein SuperFamily: syntaxin
Gene Tree: Stx4a

Human
homologs
STX4, syntaxin 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6810
neXtProt AC: NX_Q12846

Human Synonyms: p35-2, STX4A

Human Chr (Location): 16p11.2; chr16:31033095-31040168 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.
 
Interactions
Stx4a interacts with 97 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process intracellular protein transport, long-term synaptic potentiation, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding, Rab GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030969 (Evidence)
Ensembl Gene Model ENSMUSG00000030805 (Evidence)
Entrez Gene 20909 (Evidence)
UniGene 24867
DFCI TC1580713, TC1595271
DoTS DT.101382539, DT.488732
NIA Mouse Gene Index U008819
PDB 3PUK, 3PUJ
Consensus CDS Project CCDS21880.1
International Mouse Phenotyping Consortium Status Stx4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030969 VEGA Gene Model | MGI Sequence Detail 24726 C57BL/6J ±  kb
transcript OTTMUST00000076681 VEGA | MGI Sequence Detail 1456 Not Applicable 
polypeptide OTTMUSP00000040409 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015796 syntaxin-4
References
(Earliest) J:38990 Tellam JT, et al., Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86
(Latest) J:217252 Kioumourtzoglou D, et al., Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism. Mol Cell Biol. 2014 Apr;34(7):1271-9
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory