Stx4a
Gene Detail

Symbol Name ID

Stx4a syntaxin 4A (placental) MGI:893577

Synonyms

Stx4, Syn4, Syn-4

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.77 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:127824294-127849019 bp, + strand From VEGA annotation of GRCm38   24726 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Stx4a ± 2 cM)

Protein SuperFamily: syntaxin
Gene Tree: Stx4a

Human ortholog

STX4 syntaxin 4 NCBI Gene ID 6810
Human Synonyms: p35-2, STX4A
Human Chr16:31044903-31051485 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	cellular membrane fusion, intracellular protein transport, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	protein binding, Rab GTPase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	29

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(52)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030969 (Evidence)
Ensembl Gene Model	ENSMUSG00000030805 (Evidence)
Entrez Gene	20909 (Evidence)
UniGene	24867
DFCI	TC1580713, TC1595271
DoTS	DT.101382539, DT.488732
NIA Mouse Gene Index	U008819
PDB	2PJX, 3PUJ, 3PUK
Consensus CDS Project	CCDS21880.1
International Mouse Knockout Project Status	Stx4a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030969	VEGA Gene Model | MGI Sequence Detail	24726	C57BL/6J
transcript	OTTMUST00000076681	VEGA | MGI Sequence Detail	1456	Not Applicable
polypeptide	OTTMUSP00000040409	VEGA | MGI Sequence Detail	298	Not Applicable

All sequences(44) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006012	Syntaxin/epimorphin, conserved site
InterPro	IPR006011	Syntaxin, N-terminal
InterPro	IPR000727	Target SNARE coiled-coil domain
InterPro	IPR010989	t-SNARE
Protein Ontology	PR:000015796	syntaxin-4

References

(Earliest) J:38990 Tellam JT, et al., Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86
(Latest) J:189176 Ye S, et al., Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood. 2012 Sep 20;120(12):2484-92
All references(52)