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Plscr1 Gene Detail
Summary
  • Symbol
    Plscr1
  • Name
    phospholipid scramblase 1
  • Synonyms
    MmTRA1a, MmTRA1b, MuPLSCR2, NOR1, TRA1, Tras1, Tras2
  • Feature Type
    protein coding gene
  • IDs
    MGI:893575
    NCBI Gene: 22038
  • Gene Overview
    MyGene.info: PLSCR1
Location & Maps
more
  • Sequence Map
    Chr9:92249750-92272278 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22529 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
    Orthology source: HomoloGene
  • Synonyms
    MMTRA1B
  • Links
    NCBI Gene ID: 5359
    neXtProt AC: NX_O15162

  • Chr Location
    3q23; chr3:146515178-146544841 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    5
  • Genomic Mutations
    1 involving Plscr1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a grossly normal phenotype although there are hematopoietic abnormalities in newborn mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023001 VEGA Gene Model | MGI Sequence Detail 22529 C57BL/6J ±  kb
transcript OTTMUST00000055399 VEGA | MGI Sequence Detail 2302 Not Applicable  
polypeptide OTTMUSP00000026531 VEGA | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    272 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR005552 Scramblase
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:893574
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:39827 Kasukabe T, et al., TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Blood. 1997 Apr 15;89(8):2975-85
  • Latest
    J:195136 Ory S, et al., Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells. J Neurosci. 2013 Feb 20;33(8):3545-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory