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Slc26a2
Gene Detail
Symbol

Name
ID
Slc26a2
solute carrier family 26 (sulfate transporter), member 2
MGI:892977
Synonyms
Dtd, ST-OB
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.41 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:61192919-61211612 bp, - strand
From VEGA annotation of GRCm38

  18694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a2

Human
homologs
Human Homolog SLC26A2, solute carrier family 26 (anion exchanger), member 2
NCBI Gene ID 1836
neXtProt AC  NX_P50443
Human Synonyms  D5S1708, DTD, DTDST, EDM4, MST153, MSTP157
Human Chr (Location)  5q31-q34; chr5:149960737-149987400 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human SLC26A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit premature death, stunted growth, joint contractures, and skeletal dysplasia including kyphosis, shorter osteoporotic long bones, aberrant chondrocyte size, delayed endochondral bone ossification, and impaired chondrocyte proliferation and sulfate uptake.
 
Human Diseases Modeled Using Mouse Slc26a2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc26a2 interacts with 403 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (271)    Tissues (169)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 225
RT-PCR 46
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032643 (Evidence)
Ensembl Gene ModelENSMUSG00000034320 (Evidence)
Entrez Gene13521 (Evidence)
DFCITC1582121, TC1628517, TC1673420
DoTSDT.101316022, DT.487291, DT.528649, DT.94252247
NIA Mouse Gene IndexU191832
Consensus CDS ProjectCCDS29282.1
International Mouse Knockout Project StatusSlc26a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032643 VEGA Gene Model | MGI Sequence Detail 18694 C57BL/6J ±  kb
transcript OTTMUST00000081213 VEGA | MGI Sequence Detail 7814 Not Applicable 
polypeptide OTTMUSP00000043400 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002645 STAS domain
InterPro IPR001902 Sulphate anion transporter
InterPro IPR018045 Sulphate anion transporter, conserved site
InterPro IPR011547 Sulphate transporter
Protein Ontology PR:000015037 sulfate transporter
References
(Earliest) J:20552 Hastbacka J, et al., The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994 Sep 23;78(6):1073-87
(Latest) J:199554 Gualeni B, et al., Alteration of proteoglycan sulfation affects bone growth and remodeling. Bone. 2013 May;54(1):83-91
All references(42)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory