Slc26a2
Gene Detail

Symbol Name ID

Slc26a2 solute carrier family 26 (sulfate transporter), member 2 MGI:892977

Synonyms

Dtd, ST-OB

Feature Type

protein coding gene

Genetic Map

Chromosome 18

34.41 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:61192919-61211612 bp, - strand From VEGA annotation of GRCm38   18694 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:73876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a2

Human homologs

Human Homolog		SLC26A2, solute carrier family 26 (sulfate transporter), member 2
NCBI Gene ID		1836
neXtProt AC		NX_P50443
Human Synonyms		D5S1708, DTD, DTDST, EDM4, MST153, MSTP157
Human Chr (Location)		5q31-q34; chr5:149340300-149366963 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human SLC26A2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-in allele exhibit premature death, stunted growth, joint contractures, and skeletal dysplasia including kyphosis, shorter osteoporotic long bones, aberrant chondrocyte size, delayed endochondral bone ossification, and impaired chondrocyte proliferation and sulfate uptake.

 
Human Diseases Modeled Using Mouse Slc26a2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	ossification, sulfate transport, ...
Component	integral to membrane, membrane
Function	secondary active sulfate transmembrane transporter activity, sulfate transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (271)    Tissues (169)    Images (33)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	225
RT-PCR	46

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000032643 (Evidence)
Ensembl Gene Model	ENSMUSG00000034320 (Evidence)
Entrez Gene	13521 (Evidence)
DFCI	TC1582121, TC1628517, TC1673420
DoTS	DT.101316022, DT.487291, DT.528649, DT.94252247
NIA Mouse Gene Index	U191832
Consensus CDS Project	CCDS29282.1
International Mouse Knockout Project Status	Slc26a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032643	VEGA Gene Model | MGI Sequence Detail	18694	C57BL/6J
transcript	OTTMUST00000081213	VEGA | MGI Sequence Detail	7814	Not Applicable
polypeptide	OTTMUSP00000043400	VEGA | MGI Sequence Detail	739	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002645	STAS domain
InterPro	IPR001902	Sulphate anion transporter
InterPro	IPR018045	Sulphate anion transporter, conserved site
InterPro	IPR011547	Sulphate transporter
Protein Ontology	PR:000015037	sulfate transporter

References

(Earliest) J:20552 Hastbacka J, et al., The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994 Sep 23;78(6):1073-87
(Latest) J:192414 Dawson PA, et al., Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Biol Reprod. 2012 Aug;87(2):43
All references(40)