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Slc26a2 Gene Detail
Summary
  • Symbol
    Slc26a2
  • Name
    solute carrier family 26 (sulfate transporter), member 2
  • Synonyms
    Dtd, ST-OB
  • Feature Type
    protein coding gene
  • IDs
    MGI:892977
    NCBI Gene: 13521
  • Gene Overview
    MyGene.info: SLC26A2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61196854-61211596 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892977
protein coding gene Chr18:61192919-61211612 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024477
protein coding gene Chr18:61058363-61079928 (-)
A/J MGP_AJ_G0024444
protein coding gene Chr18:58442224-58461062 (-)
AKR/J MGP_AKRJ_G0024414
protein coding gene Chr18:60049530-60069465 (-)
BALB/cJ MGP_BALBcJ_G0024443
protein coding gene Chr18:58572102-58591220 (-)
C3H/HeJ MGP_C3HHeJ_G0024211
protein coding gene Chr18:60277115-60297249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024890
protein coding gene Chr18:62707329-62727460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022321
protein coding gene Chr18:57987225-58006681 (-)
CAST/EiJ MGP_CASTEiJ_G0023684
protein coding gene Chr18:60148357-60168828 (-)
CBA/J MGP_CBAJ_G0024181
protein coding gene Chr18:64726734-64748562 (-)
DBA/2J MGP_DBA2J_G0024311
protein coding gene Chr18:58109598-58128590 (-)
FVB/NJ MGP_FVBNJ_G0024277
protein coding gene Chr18:57518855-57537477 (-)
LP/J MGP_LPJ_G0024394
protein coding gene Chr18:60903886-60923602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024306
protein coding gene Chr18:66347335-66366012 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024937
protein coding gene Chr18:60242467-60262940 (-)
PWK/PhJ MGP_PWKPhJ_G0023427
protein coding gene Chr18:58339280-58358402 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023233
protein coding gene Chr18:60476995-60496409 (-)
WSB/EiJ MGP_WSBEiJ_G0023748
protein coding gene Chr18:60098785-60120991 (-)



Homology
more
  • Human Ortholog
    SLC26A2, solute carrier family 26 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC26A2, solute carrier family 26 member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D5S1708, DTD, DTDST, EDM4, MST153, MSTP157
  • Links
    NCBI Gene ID: 1836
    neXtProt AC: NX_P50443
    UniProt: P50443

  • Chr Location
    5q32; chr5:149960729-149987400 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc26a2 mouse models; 3 with human SLC26A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit premature death, stunted growth, joint contractures, and skeletal dysplasia including kyphosis, shorter osteoporotic long bones, aberrant chondrocyte size, delayed endochondral bone ossification, and impairedchondrocyte proliferation and sulfate uptake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13521 NCBI Gene Model | MGI Sequence Detail 14743 C57BL/6J ±  kb
    transcript NM_007885 RefSeq | MGI Sequence Detail 3863 C57BL/6  
    polypeptide Q62273 UniProt | EBI | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:20552 Hastbacka J, et al., The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994 Sep 23;78(6):1073-87
    • Latest
      J:237754 Maga AM, et al., Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. Front Physiol. 2015;6:92

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory