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Mal Gene Detail
Summary
  • Symbol
    Mal
  • Name
    myelin and lymphocyte protein, T cell differentiation protein
  • Synonyms
    VIP17
  • Feature Type
    protein coding gene
  • IDs
    MGI:892970
    NCBI Gene: 17153
  • Gene Overview
    MyGene.info: MAL
Location & Maps
more
  • Sequence Map
    Chr2:127633226-127656695 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23470 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.06 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAL, mal, T-cell differentiation protein
  • Vertebrate Orthologs
    12
  • Human Ortholog
    MAL, mal, T-cell differentiation protein
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 4118
    neXtProt AC: NX_P21145

  • Chr Location
    2q11.1; chr2:95025655-95053992 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mal
  • Incidental Mutations
Homozygous null mice display abnormal myelination and optic nerve morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016065 VEGA Gene Model | MGI Sequence Detail 23470 C57BL/6J ±  kb
transcript OTTMUST00000038357 VEGA | MGI Sequence Detail 2778 Not Applicable  
polypeptide OTTMUSP00000017190 VEGA | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    200 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010092 myelin and lymphocyte protein
  • InterPro Domains
    IPR008253 Marvel domain
    IPR013295 Myelin and lymphocyte (MAL) protein
Molecular
Reagents
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  • All nucleic 40
    Genomic 4
    cDNA 36

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:40050 Magyar JP, et al., Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family. Gene. 1997 Apr 21;189(2):269-75
  • Latest
    J:202804 Zhou G, et al., MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells. Mol Biol Cell. 2012 Apr;23(7):1354-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory