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Pld2 Gene Detail
Summary
  • Symbol
    Pld2
  • Name
    phospholipase D2
  • Feature Type
    protein coding gene
  • IDs
    MGI:892877
    NCBI Gene: 18806
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70430890-70448936 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892877
protein coding gene Chr11:70430318-70448936 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018602
protein coding gene Chr11:71078275-71097349 (+)
A/J MGP_AJ_G0018570
protein coding gene Chr11:68380821-68400492 (+)
AKR/J MGP_AKRJ_G0018539
protein coding gene Chr11:70437217-70458910 (+)
BALB/cJ MGP_BALBcJ_G0018542
protein coding gene Chr11:68701418-68720523 (+)
C3H/HeJ MGP_C3HHeJ_G0018355
protein coding gene Chr11:70463938-70482358 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018993
protein coding gene Chr11:73230124-73250240 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016638
protein coding gene Chr11:65302473-65320506 (+)
CAST/EiJ MGP_CASTEiJ_G0017910
protein coding gene Chr11:70719228-70740301 (+)
CBA/J MGP_CBAJ_G0018327
protein coding gene Chr11:76515553-76536113 (+)
DBA/2J MGP_DBA2J_G0018437
protein coding gene Chr11:67963434-67981775 (+)
FVB/NJ MGP_FVBNJ_G0018427
protein coding gene Chr11:67609492-67627687 (+)
LP/J MGP_LPJ_G0018507
protein coding gene Chr11:71653392-71672894 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018450
protein coding gene Chr11:77087504-77108210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019035
protein coding gene Chr11:70695549-70714126 (+)
PWK/PhJ MGP_PWKPhJ_G0017684
protein coding gene Chr11:68604787-68623914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017474
protein coding gene Chr11:70512648-70531965 (+)
WSB/EiJ MGP_WSBEiJ_G0017964
protein coding gene Chr11:70359131-70378702 (+)



Homology
more
  • Human Ortholog
    PLD2, phospholipase D2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLD2, phospholipase D2
  • Synonyms
    PLD1C
  • Links
    NCBI Gene ID: 5338
    neXtProt AC: NX_O14939
    UniProt: O14939

  • Chr Location
    17p13.2; chr17:4807152-4823434 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out fail to exhibit Abeta42 suppression of LTP and show altered brain phosphatidic acid levels. Mice homozygous for a different knock-out allele show normal platelet function, hemostasis and thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020828 Ensembl Gene Model | MGI Sequence Detail 18047 C57BL/6J ±  kb
transcript ENSMUST00000108557 Ensembl | MGI Sequence Detail 3655 Not Applicable  
polypeptide ENSMUSP00000104197 Ensembl | MGI Sequence Detail 944 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 43
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 91
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 48
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:344591 Qian T, et al., PLD2 deletion alleviates disruption of tight junctions in sepsis-induced ALI by regulating PA/STAT3 phosphorylation pathway. Int Immunopharmacol. 2023 Jan;114:109561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory