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Pld2
Gene Detail
Symbol

Name
ID
Pld2
phospholipase D2
MGI:892877
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:70540064-70558110 bp, + strand
From VEGA annotation of GRCm38

  18047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLD2
Protein SuperFamily: phospholipase D, eukaryotic type
Gene Tree: Pld2

Human
homologs
PLD2, phospholipase D2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5338
neXtProt AC: NX_O14939

Human Chr (Location): 17p13.1; chr17:4807101-4823432 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Pld2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele fail to exhibit Abeta42 suppression of LTP and altered brain phosphatidic acid levels.
 
Interactions
Pld2 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process G-protein coupled receptor internalization, inositol lipid-mediated signaling, ...
Component brush border membrane, caveola, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (251)    Tissues (102)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 251
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pld2 ; ZFIN pld2    NEW 
Molecular
reagents
All nucleic(44) Genomic(1) cDNA(42) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006051 (Evidence)
Ensembl Gene Model ENSMUSG00000020828 (Evidence)
Entrez Gene 18806 (Evidence)
UniGene 260177
DFCI TC1577592, TC1740478
DoTS DT.101379568, DT.101379564, DT.529318
NIA Mouse Gene Index U012855
EC 3.1.4.4
Consensus CDS Project CCDS24953.1
International Mouse Phenotyping Consortium Status Pld2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006051 VEGA Gene Model | MGI Sequence Detail 18047 C57BL/6J ±  kb
transcript OTTMUST00000046904 VEGA | MGI Sequence Detail 3655 Not Applicable 
polypeptide OTTMUSP00000021195 VEGA | MGI Sequence Detail 944 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(26) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016555 Phospholipase D, eukaryota
InterPro IPR015679 Phospholipase D family
InterPro IPR025202 Phospholipase D-like domain
InterPro IPR001736 Phospholipase D/Transphosphatidylase
InterPro IPR001683 Phox homologous domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012844 phospholipase D2
References
(Earliest) J:38998 Colley WC, et al., Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol. 1997 Mar 1;7(3):191-201
(Latest) J:215283 Burkhardt U, et al., Phospholipase D is a target for inhibition of astroglial proliferation by ethanol. Neuropharmacology. 2014 Apr;79:1-9
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory