About   Help   FAQ
Dgcr2 Gene Detail
Summary
  • Symbol
    Dgcr2
  • Name
    DiGeorge syndrome critical region gene 2
  • Synonyms
    9930034O06Rik, Dgcr2, Dgsc, DGS-C, Idd, Lan, Sez12
  • Feature Type
    protein coding gene
  • IDs
    MGI:892866
    NCBI Gene: 13356
  • Gene Overview
    MyGene.info: DGCR2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17840355-17891728 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.05 cM, cytoband A-B1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892866
protein coding gene Chr16:17839482-17898562 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022594
protein coding gene Chr16:15022042-15081021 (-)
A/J MGP_AJ_G0022555
protein coding gene Chr16:14274758-14329831 (-)
AKR/J MGP_AKRJ_G0022532
protein coding gene Chr16:14830293-14889506 (-)
BALB/cJ MGP_BALBcJ_G0022558
protein coding gene Chr16:14426625-14482955 (-)
C3H/HeJ MGP_C3HHeJ_G0022325
protein coding gene Chr16:14979931-15036088 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023009
protein coding gene Chr16:15256338-15323271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020529
protein coding gene Chr16:14334449-14388049 (-)
CAST/EiJ MGP_CASTEiJ_G0021853
protein coding gene Chr16:14899128-14952615 (-)
CBA/J MGP_CBAJ_G0022296
protein coding gene Chr16:15933729-15996665 (-)
DBA/2J MGP_DBA2J_G0022426
protein coding gene Chr16:14188021-14242145 (-)
FVB/NJ MGP_FVBNJ_G0022402
protein coding gene Chr16:14236613-14292128 (-)
LP/J MGP_LPJ_G0022493
protein coding gene Chr16:14799886-14864437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022423
protein coding gene Chr16:15620276-15675586 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023020
protein coding gene Chr16:14777048-14834896 (-)
PWK/PhJ MGP_PWKPhJ_G0021596
protein coding gene Chr16:14447940-14501043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021424
protein coding gene Chr16:14747599-14804219 (-)
WSB/EiJ MGP_WSBEiJ_G0021900
protein coding gene Chr16:14764324-14819270 (-)



Homology
more
  • Human Ortholog
    DGCR2, DiGeorge syndrome critical region gene 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DGCR2, DiGeorge syndrome critical region gene 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGS-C, IDD, LAN, SEZ-12
  • Links
    NCBI Gene ID: 9993
    neXtProt AC: NX_P98153
    UniProt: P98153

  • Chr Location
    22q11.21; chr22:19036282-19122454 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31292
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGCR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DGCR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13356 NCBI Gene Model | MGI Sequence Detail 51374 C57BL/6J ±  kb
    transcript NM_010048 RefSeq | MGI Sequence Detail 4099 C57BL/6  
    polypeptide P98154 UniProt | EBI | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR034010 DGCR2-like, C-type lectin-like domain
      IPR042378 Integral membrane protein DGCR2/IDD
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR001007 VWFC domain
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 29
      cDNA 28
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36046, MGI:107478, MGI:2442365
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 3
      Phenotypes 39
    • Earliest
      J:31864 Kajiwara K, et al., Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996 Feb 27;219(3):795-9
    • Latest
      J:279573 Fernandez A, et al., Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment. Neuron. 2019 Jun 19;102(6):1127-1142.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory