Dgcr2
Gene Detail

Symbol Name ID

Dgcr2 DiGeorge syndrome critical region gene 2 MGI:892866

Synonyms

9930034O06Rik, Dgcr2, Dgsc, DGS-C, Idd, Lan, Sez12

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.05 cM, cytoband A-B1
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr16:17839482-17894145 bp, - strand From VEGA annotation of GRCm38   54664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dgcr2

Human homologs

Human Homolog		DGCR2, DiGeorge syndrome critical region gene 2
NCBI Gene ID		9993
neXtProt AC		NX_P98153
Human Synonyms		DGS-C, IDD, LAN, SEZ-12
Human Chr (Location)		22q11.21; chr22:19023795-19109967 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DGCR2

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cell adhesion, response to drug
Component	integral to membrane, membrane
Function	carbohydrate binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (202)    Tissues (90)    Images (21)
Theiler Stages: 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	46
RT-PCR	156

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(29) cDNA(26) Primer pair(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037698 (Evidence)
Ensembl Gene Model	ENSMUSG00000003166 (Evidence)
Entrez Gene	13356 (Evidence)
DFCI	TC1573141, TC1586390, TC1640661, TC1727572
DoTS	DT.101133851, DT.496401, DT.55219663, DT.55281406, DT.91404668, DT.94254859, DT.94410255, DT.94410259
NIA Mouse Gene Index	U036850
Consensus CDS Project	CCDS37276.1, CCDS49785.1
International Mouse Knockout Project Status	Dgcr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037698	VEGA Gene Model | MGI Sequence Detail	54664	C57BL/6J
transcript	OTTMUST00000071606	VEGA | MGI Sequence Detail	4045	Not Applicable
polypeptide	OTTMUSP00000036732	VEGA | MGI Sequence Detail	549	Not Applicable

All sequences(112) RefSeq(4) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(202 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000006438	integral membrane protein DGCR2/IDD

References

(Earliest) J:31864 Kajiwara K, et al., Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996 Feb 27;219(3):795-9
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(52)

Other accession IDs

MGD-MRK-36046, MGI:107478, MGI:2442365