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Dgcr2
Gene Detail
 Symbol
Name
ID
Dgcr2
DiGeorge syndrome critical region gene 2
MGI:892866
Synonyms 9930034O06Rik, Dgcr2, Dgsc, DGS-C, Idd, Lan, Sez12
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.05 cM, cytoband A-B1
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr16:17839482-17894145 bp, - strand
From VEGA annotation of GRCm38

  54664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31292  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dgcr2

Human
homologs
Human Homolog DGCR2, DiGeorge syndrome critical region gene 2
NCBI Gene ID 9993
neXtProt AC  NX_P98153
Human Synonyms  DGS-C, IDD, LAN, SEZ-12
Human Chr (Location)  22q11.21; chr22:19036282-19122454 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DGCR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Dgcr2 (4)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(2)   
Interactions
Dgcr2 interacts with 265 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell adhesion, cognition, ...
Component integral component of membrane, membrane
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (202)    Tissues (91)    Images (21)
Theiler Stages: 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 46
RT-PCR 156
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(29) cDNA(26) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037698 (Evidence)
Ensembl Gene ModelENSMUSG00000003166 (Evidence)
Entrez Gene13356 (Evidence)
DFCITC1573141, TC1586390, TC1640661, TC1727572
DoTSDT.101133851, DT.496401, DT.55219663, DT.55281406, DT.91404668, DT.94254859, DT.94410255, DT.94410259
NIA Mouse Gene IndexU036850
Consensus CDS ProjectCCDS37276.1, CCDS49785.1
International Mouse Knockout Project StatusDgcr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037698 VEGA Gene Model | MGI Sequence Detail 54664 C57BL/6J ±  kb
transcript OTTMUST00000071606 VEGA | MGI Sequence Detail 4045 Not Applicable 
polypeptide OTTMUSP00000036732 VEGA | MGI Sequence Detail 549 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(8) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000006438 integral membrane protein DGCR2/IDD
References (Earliest) J:31864 Kajiwara K, et al., Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996 Feb 27;219(3):795-9
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(53)
Other
accession IDs
MGD-MRK-36046, MGI:107478, MGI:2442365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory