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Klk1b21 Gene Detail
Summary
  • Symbol
    Klk1b21
  • Name
    kallikrein 1-related peptidase b21
  • Synonyms
    Klk21, mGk-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:892022
    NCBI Gene: 16616
Location & Maps
more
  • Sequence Map
    Chr7:44102328-44106583 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4256 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.60 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLK1, kallikrein 1
  • Vertebrate Orthologs
    16
  • Human Ortholog
    KLK1, kallikrein 1
    Orthology source: HGNC
  • Synonyms
    hK1, Klk6, KLKR
  • Links
    NCBI Gene ID: 3816
    neXtProt AC: NX_P06870

  • Chr Location
    19q13.33; chr19:50819146-50823787 (-)  GRCh38.p2

  • Human Ortholog
    KLK3, kallikrein related peptidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288

  • Chr Location
    19q13.33; chr19:50854915-50877702 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KLK1 associations

Human Disease Mouse Models
       Kallikrein, Decreased Urinary Activity of   OMIM: 615953
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058319 VEGA Gene Model | MGI Sequence Detail 4256 C57BL/6J ±  kb
transcript OTTMUST00000143206 VEGA | MGI Sequence Detail 871 Not Applicable  
polypeptide OTTMUSP00000074666 VEGA | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1580 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    Genomic 82
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:8756 Evans BA, et al., Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus. J Biol Chem. 1987 Jun 15;262(17):8027-34
  • Latest
    J:232147 Isbel L, et al., Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. PLoS Genet. 2015 Dec;11(12):e1005693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory