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Klk1b5
Gene Detail
Symbol

Name
ID
Klk1b5
kallikrein 1-related peptidase b5
MGI:892020
Synonyms
Klk5, mGK-5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.73 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:44216474-44220703 bp, + strand
From VEGA annotation of GRCm38

  4230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

HCOP human homology predictions: KLK3
Protein SuperFamily: trypsin
Gene Tree: Klk1b5

Human
homologs
KLK3, kallikrein-related peptidase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 354
neXtProt AC: NX_P07288

Human Synonyms: APS, hK3, KLK2A1, PSA

Human Chr (Location): 19q13.41; chr19:50854915-50877702 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1b5 interacts with 12 markers (Mir185, Mir221, Mir296, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process proteolysis
Component extracellular exosome, extracellular space, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 38
cDNA source data(5)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(83) cDNA(5) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027272 (Evidence)
Ensembl Gene Model ENSMUSG00000066512 (Evidence)
Entrez Gene 16622 (Evidence)
EC 3.4.21.35
Consensus CDS Project CCDS21201.1
International Mouse Phenotyping Consortium Status Klk1b5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027272 VEGA Gene Model | MGI Sequence Detail 4230 C57BL/6J ±  kb
transcript OTTMUST00000067416 VEGA | MGI Sequence Detail 862 Not Applicable 
polypeptide OTTMUSP00000033921 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(140 from dbSNP Build 137)    SNPs within 2kb including multiple locations(238)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009613 kallikrein 1-related peptidase b5
References
(Earliest) J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
(Latest) J:208056 Fischer J, et al., Characterization of spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. J Invest Dermatol. 2014 May;134(5):1305-12
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory