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Klk1b8
Gene Detail
Symbol

Name
ID
Klk1b8
kallikrein 1-related peptidase b8
MGI:892018
Synonyms
Klk8, MGC:18615, mGK-8, TADG14
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:43950664-43954941 bp, + strand
From VEGA annotation of GRCm38

  4278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b8

Human
homologs
Human Homolog KLK3, kallikrein-related peptidase 3
NCBI Gene ID 354
neXtProt AC  NX_P07288
Human Synonyms  APS, hK3, KLK2A1, PSA
Human Chr (Location)  19q13.41; chr19:50854915-50860764 (+)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1b8 interacts with 11 markers (Mir27b, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process proteolysis
Component extracellular vesicular exosome, nucleus
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) Genomic(82) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027232 (Evidence)
Ensembl Gene ModelENSMUSG00000063089 (Evidence)
Entrez Gene16624 (Evidence)
UniGene435488
NIA Mouse Gene IndexU294541
EC3.4.21.35
Consensus CDS ProjectCCDS21189.1
International Mouse Knockout Project StatusKlk1b8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027232 VEGA Gene Model | MGI Sequence Detail 4278 C57BL/6J ±  kb
transcript OTTMUST00000067344 VEGA | MGI Sequence Detail 859 Not Applicable 
polypeptide OTTMUSP00000033868 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(202 from dbSNP Build 137)    SNPs within 2kb including multiple locations(206)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009614 kallikrein 1-related peptidase b8
References
(Earliest) J:8334 Fahnestock M, et al., The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland. Nucleic Acids Res. 1986 Jun 25;14(12):4823-35
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory