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Klk1b8
Gene Detail
Symbol

Name
ID
Klk1b8
kallikrein 1-related peptidase b8
MGI:892018
Synonyms
Klk8, MGC:18615, mGK-8, TADG14
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:43950664-43954941 bp, + strand
From VEGA annotation of GRCm38

  4278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

HCOP human homology predictions: KLK3
Protein SuperFamily: trypsin
Gene Tree: Klk1b8

Human
homologs
KLK3, kallikrein-related peptidase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 354
neXtProt AC: NX_P07288

Human Synonyms: APS, hK3, KLK2A1, PSA

Human Chr (Location): 19q13.41; chr19:50854915-50877702 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1b8 interacts with 11 markers (Mir27b, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process proteolysis
Component extracellular exosome, extracellular space, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) Genomic(82) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027232 (Evidence)
Ensembl Gene Model ENSMUSG00000063089 (Evidence)
Entrez Gene 16624 (Evidence)
UniGene 435488
NIA Mouse Gene Index U294541
EC 3.4.21.35
Consensus CDS Project CCDS21189.1
International Mouse Phenotyping Consortium Status Klk1b8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027232 VEGA Gene Model | MGI Sequence Detail 4278 C57BL/6J ±  kb
transcript OTTMUST00000067344 VEGA | MGI Sequence Detail 859 Not Applicable 
polypeptide OTTMUSP00000033868 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(202 from dbSNP Build 137)    SNPs within 2kb including multiple locations(206)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009614 kallikrein 1-related peptidase b8
References
(Earliest) J:8334 Fahnestock M, et al., The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland. Nucleic Acids Res. 1986 Jun 25;14(12):4823-35
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory