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Sfrp1 Gene Detail
Summary
  • Symbol
    Sfrp1
  • Name
    secreted frizzled-related protein 1
  • Synonyms
    2210415K03Rik, sFRP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:892014
    NCBI Gene: 20377
Location & Maps
more
  • Sequence Map
    Chr8:23411502-23449632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38131 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SFRP1, secreted frizzled-related protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SFRP1, secreted frizzled-related protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FRP, FRP1, FRP-1, FrzA, SARP2
  • Links
    NCBI Gene ID: 6422
    neXtProt AC: NX_Q8N474

  • Chr Location
    8p11.21; chr8:41261957-41309471 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021102 VEGA Gene Model | MGI Sequence Detail 38131 C57BL/6J ±  kb
transcript OTTMUST00000049933 VEGA | MGI Sequence Detail 4372 Not Applicable  
polypeptide OTTMUSP00000023228 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    205 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014744 secreted frizzled-related protein 1
  • InterPro Domains
    IPR020067 Frizzled domain
    IPR015526 Frizzled/secreted frizzled-related protein
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR026559 Secreted frizzled-related protein 1
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
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  • All nucleic 182
    cDNA 168
    Primer pair 9
    Other 5

    Microarray probesets 7
Other
Accession IDs
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MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814
References
more
  • Summaries
    All 138
    Developmental Gene Expression 84
    Gene Ontology 24
    Phenotypes 25
  • Earliest
    J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
  • Latest
    J:227000 Hsu LC, et al., Lhx2 regulates the timing of beta-catenin-dependent cortical neurogenesis. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12199-204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory