Sfrp1
Gene Detail

Symbol

Name
ID

Sfrp1
secreted frizzled-related protein 1
MGI:892014

Synonyms

2210415K03Rik, sFRP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8
11.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:23411502-23449632 bp, + strand From VEGA annotation of GRCm38   38131 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp1

Human
homologs

Human Homolog		SFRP1, secreted frizzled-related protein 1
NCBI Gene ID		6422
neXtProt AC		NX_Q8N474
Human Synonyms		FRP, FRP1, FRP-1, FrzA, SARP2
Human Chr (Location)		8p11.21; chr8:41261957-41309471 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 

Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.

 

Interactions

Sfrp1 interacts with 312 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (112 annotations)

Process	actin cytoskeleton organization, anterior/posterior pattern specification, ...
Component	cell surface, cytosol, ...
Function	cysteine-type endopeptidase activity, drug binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (82 records)

Data Summary: Results (482)    Tissues (318)    Images (129)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	19
RNA in situ	364
In situ reporter (knock in)	18
Northern blot	9
Western blot	7
RT-PCR	65

cDNA source data(167)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(181) cDNA(168) Primer pair(9) Other(4)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000021102 (Evidence)
Ensembl Gene Model	ENSMUSG00000031548 (Evidence)
Entrez Gene	20377 (Evidence)
UniGene	281691
DFCI	TC1713224, TC1576903, TC1735553
DoTS	DT.50316678
NIA Mouse Gene Index	U042893
Consensus CDS Project	CCDS22191.1
International Mouse Knockout Project Status	Sfrp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021102	VEGA Gene Model | MGI Sequence Detail	38131	C57BL/6J
transcript	OTTMUST00000049933	VEGA | MGI Sequence Detail	4372	Not Applicable
polypeptide	OTTMUSP00000023228	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(29) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(207 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR026559	Secreted frizzled-related protein 1
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000014744	secreted frizzled-related protein 1

References

(Earliest) J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
(Latest) J:209623 Kurosaka H, et al., Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr 1;124(4):1660-71
All references(137)

Other
accession IDs

MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814