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Sfrp1 Gene Detail
Summary
  • Symbol
    Sfrp1
  • Name
    secreted frizzled-related protein 1
  • Synonyms
    2210415K03Rik, sFRP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:892014
    NCBI Gene: 20377
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:23411502-23449632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      38131 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.48 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRP, FRP1, FRP-1, FrzA, SARP2
  • Links
    NCBI Gene ID: 6422
    neXtProt AC: NX_Q8N474
    UniProt: Q8N474

  • Chr Location
    8p11.21; chr8:41261957-41309471 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    395
  • cDNA Data
    168
  • Literature Summary
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021102 VEGA Gene Model | MGI Sequence Detail 38131 C57BL/6J ±  kb
    transcript OTTMUST00000049933 VEGA | MGI Sequence Detail 4372 Not Applicable  
    polypeptide OTTMUSP00000023228 VEGA | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      205 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 186
      cDNA 170
      Primer pair 10
      Other 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 100
      Gene Ontology 25
      Phenotypes 30
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory