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Sfrp1
Gene Detail
Symbol

Name
ID
Sfrp1
secreted frizzled-related protein 1
MGI:892014
Synonyms
2210415K03Rik, sFRP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:23411502-23449632 bp, + strand
From VEGA annotation of GRCm38

  38131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SFRP1
Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp1

Human
homologs
SFRP1, secreted frizzled-related protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6422
neXtProt AC: NX_Q8N474

Human Synonyms: FRP, FRP1, FRP-1, FrzA, SARP2

Human Chr (Location): 8p11.21; chr8:41261957-41309471 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(6)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
 
Interactions
Sfrp1 interacts with 311 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (113 annotations)
Process actin cytoskeleton organization, anterior/posterior pattern specification, ...
Component cell surface, cytosol, ...
Function cysteine-type endopeptidase activity, drug binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (482)    Tissues (318)    Images (129)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 364
In situ reporter (knock in) 18
Northern blot 9
Western blot 7
RT-PCR 65
cDNA source data(167)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SFRP1 ; Xenbase sfrp1 ; ZFIN sfrp1a, sfrp1b    NEW 
Molecular
reagents
All nucleic(181) cDNA(168) Primer pair(9) Other(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000021102 (Evidence)
Ensembl Gene Model ENSMUSG00000031548 (Evidence)
Entrez Gene 20377 (Evidence)
UniGene 281691
DFCI TC1713224, TC1576903, TC1735553
DoTS DT.50316678
NIA Mouse Gene Index U042893
Consensus CDS Project CCDS22191.1
International Mouse Phenotyping Consortium Status Sfrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021102 VEGA Gene Model | MGI Sequence Detail 38131 C57BL/6J ±  kb
transcript OTTMUST00000049933 VEGA | MGI Sequence Detail 4372 Not Applicable 
polypeptide OTTMUSP00000023228 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(207 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR026559 Secreted frizzled-related protein 1
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000014744 secreted frizzled-related protein 1
References
(Earliest) J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
(Latest) J:220152 Marcos S, et al., Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J Neurosci. 2015 Mar 18;35(11):4729-40
All references(138)
Other
accession IDs
MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory