Sfrp1 MGI Mouse Gene Detail - MGI:892014 - secreted frizzled-related protein 1

Sfrp1 Gene Detail

Symbol

Sfrp1
Name

secreted frizzled-related protein 1
Synonyms

2210415K03Rik, sFRP-1

Feature Type

protein coding gene
IDs

MGI:892014
NCBI Gene: 20377

Sequence Map

Chr8:23411502-23449632 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

38131 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 11.48 cM
Mapping Data

3 experiments

Human Ortholog

SFRP1, secreted frizzled related protein 1

Vertebrate Orthologs

11

Human Ortholog

SFRP1, secreted frizzled related protein 1
Orthology source: HomoloGene, HGNC
Synonyms

FRP, FRP1, FRP-1, FrzA, SARP2
Links

HGNC:10776

NCBI Gene ID: 6422

neXtProt AC: NX_Q8N474
Chr Location

8p11.21; chr8:41261957-41309471 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2266
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SFRP1
Protein SuperFamily

secreted frizzled-related protein
Gene Tree

Sfrp1

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Gene trapped

1
Targeted

6
Transgenic

1
Incidental Mutations

APF , CvDC

Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.

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All GO Annotations

116
GO References

24

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

505
Tissues

334
cDNA Data

167
Literature Summary

85

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA SFRP1

Xenbase sfrp1

ZFIN sfrp1a, sfrp1b

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Sfrp1 interacts with 311 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

24
RefSeq

4
UniProt

1
CCDS

CCDS22191.1
UniGene

281691

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021102	VEGA Gene Model \| MGI Sequence Detail	38131	C57BL/6J	± kb
transcript	OTTMUST00000049933	VEGA \| MGI Sequence Detail	4372	Not Applicable
polypeptide	OTTMUSP00000023228	VEGA \| MGI Sequence Detail	314	Not Applicable

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SNPs within 2kb

205 from dbSNP Build 142

RFLP

1

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UniProt

1 Sequence
Protein Ontology

PR:000014744 secreted frizzled-related protein 1
InterPro Domains

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR026559 Secreted frizzled-related protein 1

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 182

cDNA 168

Primer pair 9

Other 5

Microarray probesets 7

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MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814

Summaries

All 138

Developmental Gene Expression 85

Gene Ontology 24

Phenotypes 25
Earliest

J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
Latest

J:232894 Hrycaj SM, et al., Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development. Cell Rep. 2015 Aug 11;12(6):903-12

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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