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Agrp Gene Detail
Summary
  • Symbol
    Agrp
  • Name
    agouti related neuropeptide
  • Synonyms
    agouti related protein, Agrt
  • Feature Type
    protein coding gene
  • IDs
    MGI:892013
    NCBI Gene: 11604
Location & Maps
more
  • Sequence Map
    Chr8:105566698-105637393 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70696 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AGRP, agouti related neuropeptide
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGRP, agouti related neuropeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGRT, ART, ASIP2
  • Links
    NCBI Gene ID: 181
    neXtProt AC: NX_O00253

  • Chr Location
    16q22; chr16:67482571-67484083 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AGRP associations

Human Disease Mouse Models
       Obesity   OMIM: 601665
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 4 alleles in 8 genetic backgrounds
    25 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Gene trapped
    35
  • Targeted
    8
  • Genomic Mutations
    1 involving Agrp
  • Incidental Mutations
    APF
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050255 VEGA Gene Model | MGI Sequence Detail 70696 C57BL/6J ±  kb
transcript OTTMUST00000127665 VEGA | MGI Sequence Detail 734 Not Applicable  
polypeptide OTTMUSP00000068841 VEGA | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    109 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 106
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 57
  • Earliest
    J:39234 Shutter JR, et al., Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 1997 Mar 1;11(5):593-602
  • Latest
    J:226986 Yang L, et al., Hypothalamic PKA regulates leptin sensitivity and adiposity. Nat Commun. 2015;6:8237

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory