About   Help   FAQ
Agrp Gene Detail
Summary
  • Symbol
    Agrp
  • Name
    agouti related neuropeptide
  • Synonyms
    agouti related protein, Agrt
  • Feature Type
    protein coding gene
  • IDs
    MGI:892013
    NCBI Gene: 11604
  • Gene Overview
    MyGene.info: AGRP
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105566695-105579845 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1-D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892013
protein coding gene Chr8:105566695-105637393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034050
protein coding gene Chr8:107858837-107936495 (-)
A/J MGP_AJ_G0034031
protein coding gene Chr8:103548700-103622553 (-)
AKR/J MGP_AKRJ_G0033957
protein coding gene Chr8:106542555-106622773 (-)
BALB/cJ MGP_BALBcJ_G0034024
protein coding gene Chr8:103737612-103814110 (-)
C3H/HeJ MGP_C3HHeJ_G0033736
protein coding gene Chr8:107286783-107362988 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034544
protein coding gene Chr8:111819110-111901649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031486
protein coding gene Chr8:96691836-96758731 (-)
CAST/EiJ MGP_CASTEiJ_G0033062
protein coding gene Chr8:106787868-106863235 (-)
CBA/J MGP_CBAJ_G0033709
protein coding gene Chr8:115425711-115497289 (-)
DBA/2J MGP_DBA2J_G0033864
protein coding gene Chr8:102894645-102971212 (-)
FVB/NJ MGP_FVBNJ_G0033810
protein coding gene Chr8:101822543-101898411 (-)
LP/J MGP_LPJ_G0033955
protein coding gene Chr8:108061923-108143069 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033853
protein coding gene Chr8:118616499-118695459 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034562
protein coding gene Chr8:106511791-106586550 (-)
PWK/PhJ MGP_PWKPhJ_G0032763
protein coding gene Chr8:102285737-102359068 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032604
protein coding gene Chr8:105189414-105268571 (-)
WSB/EiJ MGP_WSBEiJ_G0033178
protein coding gene Chr8:107174062-107253216 (-)



Homology
more
  • Human Ortholog
    AGRP, agouti related neuropeptide
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGRP, agouti related neuropeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGRT, ART, ASIP2
  • Links
    NCBI Gene ID: 181
    neXtProt AC: NX_O00253
    UniProt: O00253

  • Chr Location
    16q22.1; chr16:67482571-67483813 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AGRP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 8 genetic backgrounds
    25 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11604 NCBI Gene Model | MGI Sequence Detail 13151 C57BL/6J ±  kb
    transcript NM_001271806 RefSeq | MGI Sequence Detail 777 C57BL/6  
    polypeptide P56473 UniProt | EBI | MGI Sequence Detail 131 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 104
    • Earliest
      J:39234 Shutter JR, et al., Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 1997 Mar 1;11(5):593-602
    • Latest
      J:267016 Oncul M, et al., Impaired melanocortin pathway function in Prader-Willi syndrome gene-Magel2 deficient mice. Hum Mol Genet. 2018 Sep 15;27(18):3129-3136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory