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Agrp
Gene Detail
Symbol

Name
ID
Agrp
agouti related protein
MGI:892013
Synonyms
Agrt, Art
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105566700-105568298 bp, - strand
From Ensembl annotation of GRCm38

  1599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: agouti-signaling protein/agouti-related protein
Gene Tree: Agrp

Human
homologs
Human Homolog AGRP, agouti related neuropeptide
NCBI Gene ID 181
neXtProt AC  NX_O00253
Human Synonyms  AGRT, ART, ASIP2
Human Chr (Location)  16q22; chr16:67482571-67483813 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AGRP
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(20) Targeted(8)
Genomic Mutations involving Agrp (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
 
Interactions
Agrp interacts with 4 markers (Mir325, Mir501, Mir1906-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adult feeding behavior, eating behavior, ...
Component extracellular region, extracellular space, ...
Function neuropeptide hormone activity, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (11)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 10
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000005705 (Evidence)
Entrez Gene11604 (Evidence)
DFCITC1661866, TC1589392
DoTSDT.102540030, DT.101724396, DT.110848239
Consensus CDS ProjectCCDS22605.1
International Mouse Knockout Project StatusAgrp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005705 Ensembl Gene Model | MGI Sequence Detail 1599 C57BL/6J ±  kb
transcript ENSMUST00000005849 Ensembl | MGI Sequence Detail 659 Not Applicable 
polypeptide ENSMUSP00000005849 Ensembl | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007733 Agouti
InterPro IPR027300 Agouti domain
Protein Ontology PR:000003846 agouti-related protein
References
(Earliest) J:39234 Shutter JR, et al., Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 1997 Mar 1;11(5):593-602
(Latest) J:211797 Goncalves GH, et al., Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Rep. 2014 May 22;7(4):1093-103
All references(97)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory