Agrp
Gene Detail

Symbol Name ID

Agrp agouti related protein MGI:892013

Synonyms

Agrt, Art

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.04 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:105566700-105568298 bp, - strand From Ensembl annotation of GRCm38   1599 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 chicken

Protein SuperFamily: agouti-signaling protein/agouti-related protein
Gene Tree: Agrp

Human homologs

Human Homolog		AGRP, agouti related protein homolog (mouse)
NCBI Gene ID		181
neXtProt AC		NX_O00253
Human Synonyms		AGRT, ART, ASIP2
Human Chr (Location)		16q22; chr16:67516474-67517716 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AGRP

Alleles and phenotypes

All alleles(26) : Targeted(6) Gene trapped(20)
 

Mice homozygous for a null mutation do not exhibit any detectable abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adult feeding behavior, eating behavior, ...
Component	extracellular region, extracellular space, ...
Function	neuropeptide hormone activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (11)    Tissues (9)   
Theiler Stages: 28

Assay Type	Results
RNA in situ	1
RT-PCR	10

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000005705 (Evidence)
Entrez Gene	11604 (Evidence)
DFCI	TC1589392, TC1661866
DoTS	DT.101724396, DT.102540030, DT.110848239
Consensus CDS Project	CCDS22605.1
International Mouse Knockout Project Status	Agrp

Sequences

Length	Strain/Species
genomic	ENSMUSG00000005705	Ensembl Gene Model | MGI Sequence Detail	1599	C57BL/6J
transcript	ENSMUST00000005849	Ensembl | MGI Sequence Detail	659	Not Applicable
polypeptide	ENSMUSP00000005849	Ensembl | MGI Sequence Detail	131	Not Applicable

All sequences(23) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007733	Agouti
Protein Ontology	PR:000003846	agouti-related protein

References

(Earliest) J:39234 Shutter JR, et al., Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 1997 Mar 1;11(5):593-602
(Latest) J:195318 Lu Z, et al., pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J. 2013 Mar 20;32(6):844-57
All references(82)