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Gsc2 Gene Detail
Summary
  • Symbol
    Gsc2
  • Name
    goosecoid homebox 2
  • Synonyms
    4930568H22Rik, Gscl
  • Feature Type
    protein coding gene
  • IDs
    MGI:892006
    NCBI Gene: 195333
Location & Maps
more
  • Sequence Map
    Chr16:17913107-17915059 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.10 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GSC2, goosecoid homeobox 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GSC2, goosecoid homeobox 2
    Orthology source: HomoloGene
  • Synonyms
    GSCL
  • Links
    NCBI Gene ID: 2928
    neXtProt AC: NX_O15499

  • Chr Location
    22q11.21; chr22:19148991-19150283 (-)  GRCh38.p2

Human Diseases
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  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    50 phenotype references
  • All Mutations and Alleles
    16
  • Gene trapped
    2
  • Targeted
    14
  • Genomic Mutations
    10 involving Gsc2
Mice homozygous for either one of two independently generated knock-out alleles are viable and fertile with no detectable anatomical or histological abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023599 VEGA Gene Model | MGI Sequence Detail 1953 C57BL/6J ±  kb
transcript OTTMUST00000057610 VEGA | MGI Sequence Detail 1172 Not Applicable  
polypeptide OTTMUSP00000027793 VEGA | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 27
    cDNA 10
    Primer pair 6

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923125
References
more
  • Summaries
    All 47
    Developmental Gene Expression 14
    Diseases 12
    Gene Ontology 3
    Phenotypes 50
  • Earliest
    J:32846 Halford S, et al., Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet. 1993 Dec;2(12):2099-107
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory