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Npbwr1 Gene Detail
Summary
  • Symbol
    Npbwr1
  • Name
    neuropeptides B/W receptor 1
  • Synonyms
    Gpr7
Location &
Maps
more
  • Sequence Map
    Chr1:5983926-5987617 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.89 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891989
 protein coding gene Chr1:5983926-5987617 (-)
129S1/SvImJ ENSMUSG00200001991
 protein coding gene Chr1:3377356-3381047 (-)
A/J ENSMUSG00195002688
 protein coding gene Chr1:3191668-3195367 (-)
AKR/J ENSMUSG00220003068
 protein coding gene Chr1:3251825-3255516 (-)
BALB/cJ ENSMUSG00180008407
 protein coding gene Chr1:3268998-3272695 (-)
C3H/HeJ ENSMUSG00175000290
 protein coding gene Chr1:3131885-3135576 (-)
C57BL/6NJ ENSMUSG00215003916
 protein coding gene Chr1:3174601-3178292 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013929
 protein coding gene Chr1:2589517-2593184 (-)
CAST/EiJ ENSTCUG00005002043
 protein coding gene Chr1:3514000-3517705 (-)
CBA/J ENSMUSG00210001703
 protein coding gene Chr1:3055743-3059434 (-)
DBA/2J ENSMUSG00185004420
 protein coding gene Chr1:4084884-4088581 (-)
FVB/NJ ENSMUSG00205004687
 protein coding gene Chr1:3331075-3334774 (-)
JF1/MsJ ENSUMUG00000002582
 protein coding gene Chr1:3352463-3356186 (-)
LP/J ENSMUSG00230001725
 protein coding gene Chr1:4081302-4084993 (-)
NOD/ShiLtJ ENSMUSG00190001119
 protein coding gene Chr1:3198547-3202238 (-)
NZO/HlLtJ ENSMUSG00225000144
 protein coding gene Chr1:7466356-7470053 (-)
PWK/PhJ ENSLUMG00010002215
 protein coding gene Chr1:2934171-2937861 (-)
SPRET/EiJ ENSMSPG00010013657
 protein coding gene Chr1:3535224-3536403 (-)
WSB/EiJ ENSIUOG00005010816
 protein coding gene Chr1:3159070-3162779 (-)



Homology
more
  • Human Ortholog
    NPBWR1, neuropeptides B and W receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPBWR1, neuropeptides B and W receptor 1
  • Synonyms
    GPR7
  • Links
    NCBI Gene ID: 2831
    UniProt: P48145

  • Chr Location
    8q11.23; chr8:52939182-52943734 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males develop adult-onset obesity, are hyperphagic, and have decreased energy expenditure and locomotor activity. Plasma levels of glucose, leptin and insulin are elevated in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226304 NCBI Gene Model | MGI Sequence Detail 3692 C57BL/6J ±  kb
    transcript NM_010342 RefSeq | MGI Sequence Detail 3692 C57BL/6  
    polypeptide P49681 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 42
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:27406 O'Dowd BF, et al., The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics. 1995 Jul 1;28(1):84-91
    • Latest
      J:364869 Soya S, et al., Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions. Sci Adv. 2025 Jan 17;11(3):eadn1335
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory