About   Help   FAQ
Npbwr1
Gene Detail
Symbol

Name
ID
Npbwr1
neuropeptides B/W receptor 1
MGI:891989
Synonyms
Gpr7
Feature Type
protein coding gene
Genetic Map
Chromosome 1
1.89 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:5913707-5917398 bp, - strand
From VEGA annotation of GRCm38

  3692 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NPBWR1
Protein SuperFamily: neuropeptides B/W receptor
Gene Tree: Npbwr1

Human
homologs
NPBWR1, neuropeptides B/W receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2831
neXtProt AC: NX_P48145

Human Synonyms: GPR7

Human Chr (Location): 8p22-q21.13; chr8:52939908-52940894 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males develop adult-onset obesity, are hyperphagic, and have decreased energy expenditure and locomotor activity. Plasma levels of glucose, leptin and insulin are elevated in males.
 
Interactions
Npbwr1 interacts with 223 markers (Mir1b, Mir10a, Mir10b, ...)
Expression
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase npbwr2    NEW 
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000050228 (Evidence)
Ensembl Gene Model ENSMUSG00000033774 (Evidence)
Entrez Gene 226304 (Evidence)
UniGene 291110
DFCI TC1692872
DoTS DT.40157266
NIA Mouse Gene Index U021103
Consensus CDS Project CCDS48214.1
International Mouse Phenotyping Consortium Status Npbwr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050228 VEGA Gene Model | MGI Sequence Detail 3692 C57BL/6J ±  kb
transcript OTTMUST00000127613 VEGA | MGI Sequence Detail 3692 Not Applicable 
polypeptide OTTMUSP00000068818 VEGA | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR027348 Neuropeptide B/W receptor 1
InterPro IPR009150 Neuropeptide B/W receptor family
Protein Ontology PR:000001625 neuropeptides B/W receptor type 1
References
(Earliest) J:27406 O'Dowd BF, et al., The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics. 1995 Jul 1;28(1):84-91
(Latest) J:171045 Nagata-Kuroiwa R, et al., Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory. PLoS One. 2011;6(2):e16972
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory