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Npbwr1
Gene Detail
Symbol

Name
ID
Npbwr1
neuropeptides B/W receptor 1
MGI:891989
Synonyms
Gpr7
Feature Type
protein coding gene
Genetic Map
Chromosome 1
1.89 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:5913707-5917398 bp, - strand
From NCBI annotation of GRCm38

  3692 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: neuropeptides B/W receptor
Gene Tree: Npbwr1

Human
homologs
Human Homolog NPBWR1, neuropeptides B/W receptor 1
NCBI Gene ID 2831
neXtProt AC  NX_P48145
Human Synonyms  GPR7
Human Chr (Location)  8p22-q21.13; chr8:52939908-52940894 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males develop adult-onset obesity, are hyperphagic, and have decreased energy expenditure and locomotor activity. Plasma levels of glucose, leptin and insulin are elevated in males.
 
Interactions
Npbwr1 interacts with 224 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(3)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000033774 (Evidence)
Entrez Gene226304 (Evidence)
UniGene291110
DFCITC1692872
DoTSDT.40157266
NIA Mouse Gene IndexU021103
Consensus CDS ProjectCCDS48214.1
International Mouse Knockout Project StatusNpbwr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 226304 NCBI Gene Model | MGI Sequence Detail 3692 C57BL/6J ±  kb
transcript NM_010342 RefSeq | MGI Sequence Detail 3692 C57BL/6 
polypeptide P49681 UniProt | EBI | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(12) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR027348 Neuropeptide B/W receptor 1
InterPro IPR009150 Neuropeptide B/W receptor family
Protein Ontology PR:000001625 neuropeptides B/W receptor type 1
Graphical View of Protein Domain Structure
References
(Earliest) J:27406 O'Dowd BF, et al., The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics. 1995 Jul 1;28(1):84-91
(Latest) J:171045 Nagata-Kuroiwa R, et al., Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory. PLoS One. 2011;6(2):e16972
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory