Npbwr1
Gene Detail

Symbol Name ID

Npbwr1 neuropeptides B/W receptor 1 MGI:891989

Synonyms

Gpr7

Feature Type

protein coding gene

Genetic Map

Chromosome 1

1.89 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:5913707-5917398 bp, - strand From NCBI annotation of GRCm38   3692 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: neuropeptides B/W receptor
Gene Tree: Npbwr1

Human homologs

Human Homolog		NPBWR1, neuropeptides B/W receptor 1
NCBI Gene ID		2831
neXtProt AC		NX_P48145
Human Synonyms		GPR7
Human Chr (Location)		8p22-q21.13; chr8:53852468-53853454 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null males develop adult-onset obesity, are hyperphagic, and have decreased energy expenditure and locomotor activity. Plasma levels of glucose, leptin and insulin are elevated in males.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	G-protein coupled receptor signaling pathway, regulation of metabolic process, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, neuropeptide receptor activity, ...

External Resources: FuncBase

Expression

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) Genomic(1) cDNA(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000033774 (Evidence)
Entrez Gene	226304 (Evidence)
UniGene	291110
DFCI	TC1692872
DoTS	DT.40157266
NIA Mouse Gene Index	U021103
Consensus CDS Project	CCDS48214.1
International Mouse Knockout Project Status	Npbwr1

Sequences

Length	Strain/Species
genomic	226304	NCBI Gene Model | MGI Sequence Detail	3692	C57BL/6J
transcript	NM_010342	RefSeq | MGI Sequence Detail	3692	C57BL/6
polypeptide	P49681	UniProt | EBI | MGI Sequence Detail	329	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR027348	Neuropeptide B/W receptor 1
InterPro	IPR009150	Neuropeptide B/W receptor family
Protein Ontology	PR:000001625	neuropeptides B/W receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:27406 O'Dowd BF, et al., The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics. 1995 Jul 1;28(1):84-91
(Latest) J:171045 Nagata-Kuroiwa R, et al., Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory. PLoS One. 2011;6(2):e16972
All references(23)