About   Help   FAQ
Bhlha15 Gene Detail
Summary
  • Symbol
    Bhlha15
  • Name
    basic helix-loop-helix family, member a15
  • Synonyms
    1810009C13Rik, Bhlhb8, Mist1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891976
    NCBI Gene: 17341
  • Gene Overview
    MyGene.info: BHLHA15
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144190286-144194441 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 83.05 cM, cytoband G2-G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891976
protein coding gene Chr5:144190223-144194441 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030346
protein coding gene Chr5:149514095-149518220 (+)
A/J MGP_AJ_G0030315
protein coding gene Chr5:143099590-143103715 (+)
AKR/J MGP_AKRJ_G0030247
protein coding gene Chr5:147554655-147558788 (+)
BALB/cJ MGP_BALBcJ_G0030332
protein coding gene Chr5:144344773-144348898 (+)
C3H/HeJ MGP_C3HHeJ_G0030043
protein coding gene Chr5:148397939-148402056 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030777
protein coding gene Chr5:154988267-154992390 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027996
protein coding gene Chr5:136888026-136892042 (+)
CAST/EiJ MGP_CASTEiJ_G0029448
protein coding gene Chr5:147918921-147923068 (+)
CBA/J MGP_CBAJ_G0030013
protein coding gene Chr5:161347103-161351252 (+)
DBA/2J MGP_DBA2J_G0030163
protein coding gene Chr5:142849824-142853943 (+)
FVB/NJ MGP_FVBNJ_G0030118
protein coding gene Chr5:142068361-142072654 (+)
LP/J MGP_LPJ_G0030249
protein coding gene Chr5:150127397-150131530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030149
protein coding gene Chr5:163718393-163722514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030817
protein coding gene Chr5:147443489-147447610 (+)
PWK/PhJ MGP_PWKPhJ_G0029163
protein coding gene Chr5:141960464-141964581 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028999
protein coding gene Chr5:145180672-145184769 (+)
WSB/EiJ MGP_WSBEiJ_G0029521
protein coding gene Chr5:148251457-148255577 (+)



Homology
more
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BHLHB8, MIST1
  • Links
    NCBI Gene ID: 168620
    neXtProt AC: NX_Q7RTS1
    UniProt: Q7RTS1

  • Chr Location
    7q21.3; chr7:98212254-98212959 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a generally normal phenotype. Abnormalities exist in the acinar cells of various glands and become progressively worse with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052271 Ensembl Gene Model | MGI Sequence Detail 4156 C57BL/6J ±  kb
    transcript ENSMUST00000060747 Ensembl | MGI Sequence Detail 3494 Not Applicable  
    polypeptide ENSMUSP00000055493 Ensembl | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004736 class A basic helix-loop-helix protein 15
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 36
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916361
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 29
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:39063 Lemercier C, et al., Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol. 1997 Feb 1;182(1):101-13
    • Latest
      J:257406 Metwalli KA, et al., Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development. J Dent Res. 2018 Feb;97(2):226-236

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory