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Bhlha15 Gene Detail
Summary
  • Symbol
    Bhlha15
  • Name
    basic helix-loop-helix family, member a15
  • Synonyms
    1810009C13Rik, Bhlhb8, Mist1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891976
    NCBI Gene: 17341
  • Gene Overview
    MyGene.info: BHLHA15
Location & Maps
more
  • Sequence Map
    Chr5:144190286-144194441 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4156 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 83.05 cM, cytoband G2-G3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BHLHB8, MIST1
  • Links
    NCBI Gene ID: 168620
    neXtProt AC: NX_Q7RTS1

  • Chr Location
    7q21.3; chr7:98212254-98212959 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for disruptions in this gene have a generally normal phenotype. Abnormalities exist in the acinar cells of various glands and become progressively worse with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025580 VEGA Gene Model | MGI Sequence Detail 4156 C57BL/6J ±  kb
transcript OTTMUST00000062929 VEGA | MGI Sequence Detail 3494 Not Applicable  
polypeptide OTTMUSP00000031081 VEGA | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004736 class A basic helix-loop-helix protein 15
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 38
    Genomic 1
    cDNA 35
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916361
References
more
  • Summaries
    All 77
    Developmental Gene Expression 21
    Gene Ontology 11
    Phenotypes 35
  • Earliest
    J:39063 Lemercier C, et al., Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol. 1997 Feb 1;182(1):101-13
  • Latest
    J:231905 Hendley AM, et al., p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia. Cancer Res. 2016 Jun 1;76(11):3351-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory