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Ywhaq
Gene Detail
Symbol

Name
ID
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
MGI:891963
Synonyms
14-3-3 tau, 14-3-3 theta, 2700028P07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:21390071-21417637 bp, - strand
From VEGA annotation of GRCm38

  27567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhaq

Human
homologs
Human Homolog YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
NCBI Gene ID 10971
neXtProt AC  NX_P27348
Human Synonyms  14-3-3, 1C5, HS1
Human Chr (Location)  2p25.1; chr2:9583967-9631055 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(25) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a gene trap allele are developmentally delayed and die by E14 with no specific cardiac defects; however, heterozygotes develop larger myocardial infarctions with increased post-infarction cardiac remodeling while cultured cardiomyocytes are sensitized to proapoptotic stimuli.
 
Interactions
Ywhaq interacts with 276 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process negative regulation of transcription, DNA-templated, oxidation-reduction process, ...
Component cell, cytoplasm, ...
Function 14-3-3 protein binding, monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (83)    Tissues (79)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 48
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(32) Primer pair(3) Other(1)
Microarray probesets(10)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016335 VEGA Gene Model | MGI Sequence Detail 27567 C57BL/6J ±  kb
transcript OTTMUST00000039251 VEGA | MGI Sequence Detail 2197 Not Applicable 
polypeptide OTTMUSP00000017542 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000017552 14-3-3 protein theta
References
(Earliest) J:39910 Hatada I, et al., New p57KIP2 mutations in Beckwith-Wiedemann syndrome. Hum Genet. 1997 Oct;100(5-6):681-3
(Latest) J:211623 Ben-Addi A, et al., IkappaB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403
All references(55)
Other
accession IDs
MGI:1924055, MGI:2144732, MGI:2144953, MGI:2145131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory