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Ywhaq Gene Detail
Summary
  • Symbol
    Ywhaq
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
  • Synonyms
    14-3-3 tau, 14-3-3 theta, 2700028P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:891963
    NCBI Gene: 22630
  • Gene Overview
    MyGene.info: YWHAQ
Location & Maps
more
  • Sequence Map
    Chr12:21390071-21417637 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27567 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    14-3-3, 1C5, HS1
  • Links
    NCBI Gene ID: 10971
    neXtProt AC: NX_P27348

  • Chr Location
    2p25.1; chr2:9583967-9631055 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap allele are developmentally delayed and die by E14 with no specific cardiac defects; however, heterozygotes develop larger myocardial infarctions with increased post-infarction cardiac remodeling while cultured cardiomyocytes are sensitized to proapoptotic stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016335 VEGA Gene Model | MGI Sequence Detail 27567 C57BL/6J ±  kb
transcript OTTMUST00000039251 VEGA | MGI Sequence Detail 2197 Not Applicable  
polypeptide OTTMUSP00000017542 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    320 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 36
    cDNA 32
    Primer pair 3
    Other 1

    Microarray probesets 10
Other
Accession IDs
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MGI:1924055, MGI:2144732, MGI:2144953, MGI:2145131
References
more
  • Summaries
    All 50
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:39910 Hatada I, et al., New p57KIP2 mutations in Beckwith-Wiedemann syndrome. Hum Genet. 1997 Oct;100(5-6):681-3
  • Latest
    J:222137 Batra N, et al., 14-3-3theta facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels. J Cell Sci. 2014 Jan 1;127(Pt 1):137-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory