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Ywhaq
Gene Detail
 Symbol
Name
ID
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
MGI:891963
Synonyms 14-3-3 tau, 14-3-3 theta, 2700028P07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:21390071-21417637 bp, - strand
From VEGA annotation of GRCm38

  27567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhaq

Human
homologs
Human Homolog YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
NCBI Gene ID 10971
neXtProt AC  NX_P27348
Human Synonyms  14-3-3, 1C5, HS1
Human Chr (Location)  2p25.1; chr2:9583967-9631055 (-)  GRCh38
Alleles
and
phenotypes
All alleles(27) : Targeted(2) Gene trapped(25)
 
Embryos homozygous for a gene trap allele are developmentally delayed and die by E14 with no specific cardiac defects; however, heterozygotes develop larger myocardial infarctions with increased post-infarction cardiac remodeling while cultured cardiomyocytes are sensitized to proapoptotic stimuli.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process negative regulation of transcription, DNA-templated, oxidation-reduction process, ...
Component cell, cytoplasm, ...
Function 14-3-3 protein binding, monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (83)    Tissues (79)    Images (4)
Theiler Stages: 17, 18, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 35
RT-PCR 48
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) cDNA(32) Primer pair(3) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000016335 (Evidence)
Ensembl Gene ModelENSMUSG00000076432 (Evidence)
Entrez Gene22630 (Evidence)
DFCITC1573720, TC1706187, TC1722596, TC1731211, TC1748262
DoTSDT.101325460, DT.101325462, DT.101719473, DT.103572861, DT.103586843, DT.103589331, DT.110948460, DT.55107405, DT.55205652, DT.91366140, DT.91377747, DT.94303257, DT.97338336, DT.99867840
NIA Mouse Gene IndexU044176, U085440, U111248, U194539
Consensus CDS ProjectCCDS25837.1
International Mouse Knockout Project StatusYwhaq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016335 VEGA Gene Model | MGI Sequence Detail 27567 C57BL/6J ±  kb
transcript OTTMUST00000039251 VEGA | MGI Sequence Detail 2197 Not Applicable 
polypeptide OTTMUSP00000017542 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000017552 14-3-3 protein theta
References (Earliest) J:39910 Hatada I, et al., New p57KIP2 mutations in Beckwith-Wiedemann syndrome. Hum Genet. 1997 Oct;100(5-6):681-3
(Latest) J:196985 Yam PT, et al., 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron. 2012 Nov 21;76(4):735-49
All references(53)
Other
accession IDs
MGI:1924055, MGI:2144732, MGI:2144953, MGI:2145131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory