Cyp2f2
Gene Detail

Symbol

Name
ID

Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
MGI:88608

Synonyms

Cyp2f

Feature Type

protein coding gene

Genetic Map

Chromosome 7
15.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:27119909-27133660 bp, + strand From VEGA annotation of GRCm38   13752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:73898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2f2

Human
homologs

Human Homolog		CYP2F1, cytochrome P450, family 2, subfamily F, polypeptide 1
NCBI Gene ID		1572
neXtProt AC		NX_P24903
Human Synonyms		C2F1, CYP2F
Human Chr (Location)		19q13.2; chr19:41114448-41128376 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.

 

Interactions

Cyp2f2 interacts with 46 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (29 annotations)

Process	epoxygenase P450 pathway, exogenous drug catabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	2-octaprenyl-6-methoxyphenol hydroxylase activity, arachidonic acid epoxygenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (147)    Tissues (115)    Images (20)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	133
RT-PCR	14

cDNA source data(298)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(301) cDNA(299) Primer pair(2)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000027204 (Evidence)
Ensembl Gene Model	ENSMUSG00000052974 (Evidence)
Entrez Gene	13107 (Evidence)
UniGene	4515
DFCI	TC1572625, TC1627137
DoTS	DT.536563, DT.91438009, DT.97370632
NIA Mouse Gene Index	U099319, U217377
EC	1.14.14.-
Consensus CDS Project	CCDS21010.1
International Mouse Knockout Project Status	Cyp2f2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027204	VEGA Gene Model | MGI Sequence Detail	13752	C57BL/6J
transcript	OTTMUST00000067266	VEGA | MGI Sequence Detail	1866	Not Applicable
polypeptide	OTTMUSP00000033816	VEGA | MGI Sequence Detail	491	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(143 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR020469	Cytochrome P450, CYP2 family
InterPro	IPR002401	Cytochrome P450, E-class, group I
Protein Ontology	PR:000006238	cytochrome P450 2F2

References

(Earliest) J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
(Latest) J:198191 Li C, et al., Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1;378(1):13-24
All references(47)

Other
accession IDs

MGD-MRK-2328, MGD-MRK-2329