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Cyp2f2 Gene Detail
Summary
  • Symbol
    Cyp2f2
  • Name
    cytochrome P450, family 2, subfamily f, polypeptide 2
  • Synonyms
    Cyp2f
  • Feature Type
    protein coding gene
  • IDs
    MGI:88608
    NCBI Gene: 13107
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27119955-27133660 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 15.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88608
protein coding gene Chr7:27119909-27133660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031895
protein coding gene Chr7:25728914-25744598 (+)
A/J MGP_AJ_G0031874
protein coding gene Chr7:25121985-25135632 (+)
AKR/J MGP_AKRJ_G0031804
protein coding gene Chr7:25800011-25812771 (+)
BALB/cJ MGP_BALBcJ_G0031879
protein coding gene Chr7:25350357-25363804 (+)
C3H/HeJ MGP_C3HHeJ_G0031601
protein coding gene Chr7:26171390-26187674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032344
protein coding gene Chr7:26571664-26594756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029396
protein coding gene Chr7:26367315-26380774 (+)
CAST/EiJ MGP_CASTEiJ_G0030936
protein coding gene Chr7:19462068-19478440 (+)
CBA/J MGP_CBAJ_G0031566
protein coding gene Chr7:27739304-27761496 (+)
DBA/2J MGP_DBA2J_G0031718
protein coding gene Chr7:24931309-24946060 (+)
FVB/NJ MGP_FVBNJ_G0031674
protein coding gene Chr7:25013930-25027397 (+)
LP/J MGP_LPJ_G0031798
protein coding gene Chr7:26058494-26076292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031709
protein coding gene Chr7:27360455-27374112 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032375
protein coding gene Chr7:25314100-25335941 (+)
PWK/PhJ MGP_PWKPhJ_G0030660
protein coding gene Chr7:19963130-19977751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030494
protein coding gene Chr7:16309308-16326823 (+)
WSB/EiJ MGP_WSBEiJ_G0031044
protein coding gene Chr7:25613478-25628104 (+)



Homology
more
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
    Orthology source: HomoloGene
  • Synonyms
    C2F1, CYP2F, CYPIIF1
  • Links
    NCBI Gene ID: 1572
    neXtProt AC: NX_P24903
    UniProt: P24903

  • Chr Location
    19q13.2; chr19:41114292-41128381 (+)  GRCh38.p7

  • Human Ortholog
    CYP2F2P, cytochrome P450 family 2 subfamily F member 2, pseudogene
    Orthology source: HGNC
  • Synonyms
    CYP2F1P
  • Links
    NCBI Gene ID: 171427

  • Chr Location
    19q13.2; chr19:40818477-40826773 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13107 NCBI Gene Model | MGI Sequence Detail 13706 C57BL/6J ±  kb
transcript NM_007817 RefSeq | MGI Sequence Detail 1842 C57BL/6  
polypeptide P33267 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 302
    cDNA 300
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2328, MGD-MRK-2329
References
more
  • Summaries
    All 49
    Developmental Gene Expression 16
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
  • Latest
    J:257716 Cruzan G, et al., Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. Toxicol Sci. 2017 Oct 1;159(2):413-421

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory