Cyp2f2 MGI Mouse Gene Detail - MGI:88608 - cytochrome P450, family 2, subfamily f, polypeptide 2

Cyp2f2 Gene Detail

Symbol

Cyp2f2
Name

cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms

Cyp2f

Feature Type

protein coding gene
IDs

MGI:88608
NCBI Gene: 13107
Gene Overview

MyGene.info: CYP2F1

Sequence Map

Chr7:27119909-27133660 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

13752 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.82 cM
Mapping Data

1 experiment

Human Ortholog

CYP2F1, cytochrome P450 family 2 subfamily F member 1

Vertebrate Orthologs

6

Human Ortholog

CYP2F1, cytochrome P450 family 2 subfamily F member 1
Orthology source: HomoloGene, HGNC
Synonyms

C2F1, CYP2F, CYPIIF1
Links

HGNC:2632

NCBI Gene ID: 1572

neXtProt AC: NX_P24903

UniProt: P24903
Chr Location

19q13.2; chr19:41114292-41128381 (+) GRCh38.p7

Human Ortholog

CYP2F2P, cytochrome P450 family 2 subfamily F member 2, pseudogene
Orthology source: HGNC
Synonyms

CYP2F1P
Links

HGNC:18851

NCBI Gene ID: 171427
Chr Location

19q13.2; chr19:40818477-40826773 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 73898
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CYP2F1, CYP2F2P
Protein SuperFamily

cytochrome P450 CYP2D6
Gene Tree

Cyp2f2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Cyp2f2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

147
Tissues

115
cDNA Data

298
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyp2f2

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Cyp2f2 interacts with 46 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

24
RefSeq

2
UniProt

2
CCDS

CCDS21010.1
UniGene

4515

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027204	VEGA Gene Model \| MGI Sequence Detail	13752	C57BL/6J	± kb
transcript	OTTMUST00000067266	VEGA \| MGI Sequence Detail	1866	Not Applicable
polypeptide	OTTMUSP00000033816	VEGA \| MGI Sequence Detail	491	Not Applicable

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SNPs within 2kb

141 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000006238 cytochrome P450 2F2

(term hierarchy)
EC

1.14.14.-
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR020469 Cytochrome P450, CYP2 family

IPR002401 Cytochrome P450, E-class, group I

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All nucleic 301

cDNA 299

Primer pair 2

Microarray probesets 3

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MGD-MRK-2328, MGD-MRK-2329

Summaries

All 44

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 6
Earliest

J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
Latest

J:216691 Li L, et al., Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse. Carcinogenesis. 2014 Nov;35(11):2584-91

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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