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Cyp2f2 Gene Detail
Summary
  • Symbol
    Cyp2f2
  • Name
    cytochrome P450, family 2, subfamily f, polypeptide 2
  • Synonyms
    Cyp2f
  • Feature Type
    protein coding gene
  • IDs
    MGI:88608
    NCBI Gene: 13107
  • Gene Overview
    MyGene.info: CYP2F1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:27119909-27133660 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13752 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.82 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2F1, CYP2F, CYPIIF1
  • Links
    NCBI Gene ID: 1572
    neXtProt AC: NX_P24903
    UniProt: P24903

  • Chr Location
    19q13.2; chr19:41114292-41128381 (+)  GRCh38.p7
  • Human Ortholog
    CYP2F2P, cytochrome P450 family 2 subfamily F member 2, pseudogene
    Orthology source: HGNC
  • Synonyms
    CYP2F1P
  • Links
    NCBI Gene ID: 171427

  • Chr Location
    19q13.2; chr19:40818477-40826773 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    147
  • Tissues
    115
  • cDNA Data
    298
  • Literature Summary
    15
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027204 VEGA Gene Model | MGI Sequence Detail 13752 C57BL/6J ±  kb
transcript OTTMUST00000067266 VEGA | MGI Sequence Detail 1866 Not Applicable  
polypeptide OTTMUSP00000033816 VEGA | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    141 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 301
    cDNA 299
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2328, MGD-MRK-2329
References
more
  • Summaries
    All 47
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
  • Latest
    J:257716 Cruzan G, et al., Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. Toxicol Sci. 2017 Oct 1;159(2):413-421
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2018
MGI 6.12 		The Jackson Laboratory