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Cyp2f2 Gene Detail
Summary
  • Symbol
    Cyp2f2
  • Name
    cytochrome P450, family 2, subfamily f, polypeptide 2
  • Synonyms
    Cyp2f
  • Feature Type
    protein coding gene
  • IDs
    MGI:88608
    NCBI Gene: 13107
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26819380-26833085 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88608
 protein coding gene Chr7:26819334-26833085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031895
 protein coding gene Chr7:25728914-25744598 (+)
A/J MGP_AJ_G0031874
 protein coding gene Chr7:25121985-25135632 (+)
AKR/J MGP_AKRJ_G0031804
 protein coding gene Chr7:25800011-25812771 (+)
BALB/cJ MGP_BALBcJ_G0031879
 protein coding gene Chr7:25350357-25363804 (+)
C3H/HeJ MGP_C3HHeJ_G0031601
 protein coding gene Chr7:26171390-26187674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032344
 protein coding gene Chr7:26571664-26594756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029396
 protein coding gene Chr7:26367315-26380774 (+)
CAST/EiJ MGP_CASTEiJ_G0030936
 protein coding gene Chr7:19462068-19478440 (+)
CBA/J MGP_CBAJ_G0031566
 protein coding gene Chr7:27739304-27761496 (+)
DBA/2J MGP_DBA2J_G0031718
 protein coding gene Chr7:24931309-24946060 (+)
FVB/NJ MGP_FVBNJ_G0031674
 protein coding gene Chr7:25013930-25027397 (+)
LP/J MGP_LPJ_G0031798
 protein coding gene Chr7:26058494-26076292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031709
 protein coding gene Chr7:27360455-27374112 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032375
 protein coding gene Chr7:25314100-25335941 (+)
PWK/PhJ MGP_PWKPhJ_G0030660
 protein coding gene Chr7:19963130-19977751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030494
 protein coding gene Chr7:16309308-16326823 (+)
WSB/EiJ MGP_WSBEiJ_G0031044
 protein coding gene Chr7:25613478-25628104 (+)



Homology
more
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2F1, cytochrome P450 family 2 subfamily F member 1
  • Synonyms
    C2F1, CYP2F, CYPIIF1
  • Links
    NCBI Gene ID: 1572
    neXtProt AC: NX_P24903
    UniProt: P24903

  • Chr Location
    19q13.2; chr19:41114292-41128381 (+)  GRCh38.p7
  • Human Ortholog
    CYP2F2P, cytochrome P450 family 2 subfamily F member 2, pseudogene
  • Synonyms
    CYP2F1P
  • Links
    NCBI Gene ID: 171427

  • Chr Location
    19q13.2; chr19:40818477-40826773 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    116
  • cDNA Data
    299
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13107 NCBI Gene Model | MGI Sequence Detail 13706 C57BL/6J ±  kb
    transcript NM_007817 RefSeq | MGI Sequence Detail 1842 C57BL/6  
    polypeptide P33267 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 303
      cDNA 300
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2328, MGD-MRK-2329
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 17
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
    • Latest
      J:294646 Stupnikov MR, et al., Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation. Elife. 2019 Oct 21;8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    09/14/2021
    MGI 6.17     		The Jackson Laboratory