Cyp2f2 MGI Mouse Gene Detail - MGI:88608 - cytochrome P450, family 2, subfamily f, polypeptide 2

Symbol

Cyp2f2
Name

cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms

Cyp2f

Feature Type

protein coding gene
IDs

MGI:88608
NCBI Gene: 13107
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:27119955-27133660 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.82 cM
Mapping Data

1 experiment

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88608	protein coding gene	Chr7:27119909-27133660 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031895	protein coding gene	Chr7:25728914-25744598 (+)
A/J	MGP_AJ_G0031874	protein coding gene	Chr7:25121985-25135632 (+)
AKR/J	MGP_AKRJ_G0031804	protein coding gene	Chr7:25800011-25812771 (+)
BALB/cJ	MGP_BALBcJ_G0031879	protein coding gene	Chr7:25350357-25363804 (+)
C3H/HeJ	MGP_C3HHeJ_G0031601	protein coding gene	Chr7:26171390-26187674 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032344	protein coding gene	Chr7:26571664-26594756 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029396	protein coding gene	Chr7:26367315-26380774 (+)
CAST/EiJ	MGP_CASTEiJ_G0030936	protein coding gene	Chr7:19462068-19478440 (+)
CBA/J	MGP_CBAJ_G0031566	protein coding gene	Chr7:27739304-27761496 (+)
DBA/2J	MGP_DBA2J_G0031718	protein coding gene	Chr7:24931309-24946060 (+)
FVB/NJ	MGP_FVBNJ_G0031674	protein coding gene	Chr7:25013930-25027397 (+)
LP/J	MGP_LPJ_G0031798	protein coding gene	Chr7:26058494-26076292 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031709	protein coding gene	Chr7:27360455-27374112 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032375	protein coding gene	Chr7:25314100-25335941 (+)
PWK/PhJ	MGP_PWKPhJ_G0030660	protein coding gene	Chr7:19963130-19977751 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030494	protein coding gene	Chr7:16309308-16326823 (+)
WSB/EiJ	MGP_WSBEiJ_G0031044	protein coding gene	Chr7:25613478-25628104 (+)

Human Ortholog

CYP2F1, cytochrome P450 family 2 subfamily F member 1

Vertebrate Orthologs

6

Human Ortholog

CYP2F1, cytochrome P450 family 2 subfamily F member 1
Orthology source: HomoloGene
Synonyms

C2F1, CYP2F, CYPIIF1
Links

HGNC:2632

NCBI Gene ID: 1572

neXtProt AC: NX_P24903

UniProt: P24903
Chr Location

19q13.2; chr19:41114292-41128381 (+) GRCh38.p7

Human Ortholog

CYP2F2P, cytochrome P450 family 2 subfamily F member 2, pseudogene
Orthology source: HGNC
Synonyms

CYP2F1P
Links

HGNC:18851

NCBI Gene ID: 171427
Chr Location

19q13.2; chr19:40818477-40826773 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 73898
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CYP2F1, CYP2F2P
Protein SuperFamily

cytochrome P450 CYP2D6
Gene Tree

Cyp2f2

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Cyp2f2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs.

less

All GO Annotations

27
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

147
Tissues

115
cDNA Data

299
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyp2a6.8

less

Cyp2f2 interacts with 46 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS21010.1
UniGene

4515

Ensembl

ENSMUSG00000052974 (Evidence)
NCBI Gene

13107

			Length	Strain/Species	Flank
genomic	13107	NCBI Gene Model \| MGI Sequence Detail	13706	C57BL/6J	± kb
transcript	NM_007817	RefSeq \| MGI Sequence Detail	1842	C57BL/6
polypeptide	P33267	UniProt \| EBI \| MGI Sequence Detail	491	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000006238 cytochrome P450 2F2

(term hierarchy)
EC

1.14.14.-
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR020469 Cytochrome P450, CYP2 family

IPR002401 Cytochrome P450, E-class, group I

IPR036396 Cytochrome P450 superfamily

less

All nucleic 302

cDNA 300

Primer pair 2

Microarray probesets 3

less

MGD-MRK-2328, MGD-MRK-2329

Summaries

All 49

Developmental Gene Expression 16

Gene Ontology 6

Phenotypes 9
Earliest

J:10678 Nhamburo PT, et al., The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. Biochemistry. 1990 Jun 12;29(23):5491-9
Latest

J:257716 Cruzan G, et al., Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. Toxicol Sci. 2017 Oct 1;159(2):413-421

TSS for Cyp2f2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65202	Chr7:27119749-27119765 (+)	-198 bp
Tssr65203	Chr7:27119948-27119966 (+)	2 bp
Tssr65205	Chr7:27121491-27121500 (+)	1,541 bp
Tssr65206	Chr7:27121536-27121549 (+)	1,588 bp
Tssr65207	Chr7:27121572-27121621 (+)	1,642 bp
Tssr65208	Chr7:27121622-27121635 (+)	1,674 bp
Tssr65209	Chr7:27121640-27121660 (+)	1,695 bp
Tssr65210	Chr7:27121665-27121677 (+)	1,716 bp
Tssr65211	Chr7:27121686-27121716 (+)	1,746 bp
Tssr65212	Chr7:27121841-27121897 (+)	1,914 bp
Tssr65213	Chr7:27121917-27121932 (+)	1,970 bp
Tssr65214	Chr7:27121940-27121969 (+)	2,000 bp
Tssr65215	Chr7:27122133-27122144 (+)	2,184 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/12/2019 MGI 6.14