Cyp2d Complex/Cluster/Region Detail

Summary

• Symbol
  Cyp2d
• Name
  cytochrome P450, 2d region

• Feature Type
  complex/cluster/region
• IDs
  MGI:88601
  NCBI Gene: 111370
• Cluster Members
  Cyp2d22, Cyp2d11, Cyp2d10 ... (13 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 15, Syntenic
• Mapping Data
  8 experiments

Strain
Comparison

• RFLP
  1

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  5 phenotype references
  

• All Mutations and Alleles
  6
• Targeted
  6
• Find Mice (IMSR)
  2 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  111370

Molecular
Reagents

• All nucleic 2

  cDNA 1

  Other 1

Other
Accession IDs

MGD-MRK-2320

References

• Summaries
  All 17

  Phenotypes 5
• Earliest
  J:8711 Gonzalez FJ, et al., Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. DNA. 1987 Apr;6(2):149-61
• Latest
  J:286122 Henderson CJ, et al., An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos. 2019 Jun;47(6):601-615

Cyp2d Cluster contains:

More Data for these features

Member	Feature Type	Location
Cyp2d22, cytochrome P450, family 2, subfamily d, polypeptide 22	protein coding gene	Chr15:82254728-82264461 (-)
Cyp2d11, cytochrome P450, family 2, subfamily d, polypeptide 11	protein coding gene	Chr15:82273355-82278223 (-)
Cyp2d10, cytochrome P450, family 2, subfamily d, polypeptide 10	protein coding gene	Chr15:82287047-82291396 (-)
Cyp2d9, cytochrome P450, family 2, subfamily d, polypeptide 9	protein coding gene	Chr15:82336578-82341028 (+)
Cyp2d32-ps, cytochrome P450, family 2, subfamily d, polypeptide 32, pseudogene	pseudogene	Chr15:82346822-82349312 (+)
Cyp2d12, cytochrome P450, family 2, subfamily d, polypeptide 12	protein coding gene	Chr15:82439244-82443614 (+)
Cyp2d33-ps, cytochrome P450, family 2, subfamily d, polypeptide 33, pseudogene	pseudogene	Chr15:82446398-82449719 (+)
Cyp2d34, cytochrome P450, family 2, subfamily d, polypeptide 34	protein coding gene	Chr15:82500166-82505147 (-)
Cyp2d13, cytochrome P450, family 2, subfamily d, polypeptide 13	polymorphic pseudogene	Chr15:82520951-82526246 (-)
Cyp2d36-ps, cytochrome P450, family 2, subfamily d, polypeptide 36, pseudogene	pseudogene	Chr15:82555489-82567458 (-)
Cyp2d37-ps, cytochrome P450, family 2, subfamily d, polypeptide 37, pseudogene	pseudogene	Chr15:82572951-82574259 (-)
Cyp2d40, cytochrome P450, family 2, subfamily d, polypeptide 40	protein coding gene	Chr15:82644034-82648323 (-)
Cyp2d26, cytochrome P450, family 2, subfamily d, polypeptide 26	protein coding gene	Chr15:82674302-82678495 (-)