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Cyp2b10 Gene Detail
Summary
  • Symbol
    Cyp2b10
  • Name
    cytochrome P450, family 2, subfamily b, polypeptide 10
  • Synonyms
    Cyp2b, Cyp2b20, p16, phenobarbitol inducible, type b
  • Feature Type
    protein coding gene
  • IDs
    MGI:88598
    NCBI Gene: 13088
  • Gene Overview
    MyGene.info: CYP2B6
Location & Maps
more
  • Sequence Map
    Chr7:25897620-25926624 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29005 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 14.11 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CYP2B6, cytochrome P450 family 2 subfamily B member 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CYP2B6, cytochrome P450 family 2 subfamily B member 6
    Orthology source: HomoloGene
  • Synonyms
    CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450
  • Links
    NCBI Gene ID: 1555
    neXtProt AC: NX_P20813

  • Chr Location
    19q13.2; chr19:40991229-41018398 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CYP2B6 associations

Human Disease Mouse Models
       Efavirenz, Poor Metabolism of   OMIM: 614546
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    2 involving Cyp2b10
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027165 VEGA Gene Model | MGI Sequence Detail 29005 C57BL/6J ±  kb
transcript OTTMUST00000067193 VEGA | MGI Sequence Detail 1822 Not Applicable  
polypeptide OTTMUSP00000033773 VEGA | MGI Sequence Detail 500 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    321 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 3
    cDNA 21
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-2315, MGD-MRK-2316, MGI:1202389
References
more
  • Summaries
    All 58
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:6425 Atlas SA, et al., Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice. Dev Pharmacol Ther. 1980;1(5):281-304
  • Latest
    J:225381 Ohno M, et al., The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. PLoS One. 2014;9(12):e115663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory