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Cyp2a5
Gene Detail
 Symbol
Name
ID
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
MGI:88597
Synonyms Coh
Feature Type protein coding gene
Genetic Map
Chromosome 7
15.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr7:26835305-26843548 bp, + strand
From VEGA annotation of GRCm38

  8244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85917  Vertebrate Homology Class
3 human; 2 mouse; 1 rat; 1 rhesus macaque

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2a5

Human
homologs
Human Homolog CYP2A6, cytochrome P450, family 2, subfamily A, polypeptide 6
NCBI Gene ID 1548
neXtProt AC  NX_P11509
Human Synonyms  CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Human Chr (Location)  19q13.2; chr19:40843538-40850447 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human CYP2A6
Human Homolog CYP2A7, cytochrome P450, family 2, subfamily A, polypeptide 7
NCBI Gene ID 1549
neXtProt AC  NX_P20853
Human Synonyms  CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
Human Chr (Location)  19q13.2; chr19:40875439-40882752 (-)  GRCh38
Human Homolog CYP2A13, cytochrome P450, family 2, subfamily A, polypeptide 13
NCBI Gene ID 1553
neXtProt AC  NX_Q16696
Human Synonyms  CPAD, CYP2A, CYPIIA13
Human Chr (Location)  19q13.2; chr19:41088451-41096195 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cellular response to cadmium ion, heme metabolic process, ...
Component cytoplasmic microtubule
Function coumarin 7-hydroxylase activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (113)    Tissues (96)    Images (18)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 113
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(4) cDNA(15)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000036784 (Evidence)
Ensembl Gene ModelENSMUSG00000005547 (Evidence)
Entrez Gene13087 (Evidence)
Consensus CDS ProjectCCDS21008.1
International Mouse Knockout Project StatusCyp2a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036784 VEGA Gene Model | MGI Sequence Detail 8244 C57BL/6J ±  kb
transcript OTTMUST00000094406 VEGA | MGI Sequence Detail 2013 Not Applicable 
polypeptide OTTMUSP00000052492 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4)
Polymorphisms RFLP(4) : SNPs within 2kb(164 from dbSNP Build 137)    SNPs within 2kb including multiple locations(338)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006221 cytochrome P450 2A5
References (Earliest) J:5987 Lush IE, et al., Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res. 1978 Apr;31(2):177-86
(Latest) J:204373 Megaraj V, et al., Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. Carcinogenesis. 2014 Jan;35(1):131-7
All references(55)
Other
accession IDs
MGD-MRK-2050, MGD-MRK-2299, MGD-MRK-2314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory