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Cyp2a5
Gene Detail
Symbol

Name
ID
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
MGI:88597
Synonyms
Coh
Feature Type
protein coding gene
Genetic Map
Chromosome 7
15.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr7:26835305-26843548 bp, + strand
From VEGA annotation of GRCm38

  8244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85917  Vertebrate Homology Class
3 human; 2 mouse; 1 rat; 1 rhesus macaque; 7 western clawed frog

HCOP human homology predictions: CYP2A13, CYP2A6, CYP2A7
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2a5

Human
homologs
CYP2A13, cytochrome P450, family 2, subfamily A, polypeptide 13
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1553
neXtProt AC: NX_Q16696

Human Synonyms: CPAD, CYP2A, CYPIIA13

Human Chr (Location): 19q13.2; chr19:41088451-41096195 (+)  GRCh38.p2

  2 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Cyp2a5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine.
 
Interactions
Cyp2a5 interacts with 109 markers (Mir18, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to cadmium ion, coumarin metabolic process, ...
Component cytoplasm, cytoplasmic microtubule, ...
Function arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (113)    Tissues (96)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(4) cDNA(15)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000036784 (Evidence)
Ensembl Gene Model ENSMUSG00000005547 (Evidence)
Entrez Gene 13087 (Evidence)
Consensus CDS Project CCDS21008.1
International Mouse Phenotyping Consortium Status Cyp2a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036784 VEGA Gene Model | MGI Sequence Detail 8244 C57BL/6J ±  kb
transcript OTTMUST00000094406 VEGA | MGI Sequence Detail 2013 Not Applicable 
polypeptide OTTMUSP00000052492 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4)
Polymorphisms
RFLP(4) : SNPs within 2kb(164 from dbSNP Build 137)    SNPs within 2kb including multiple locations(338)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006221 cytochrome P450 2A5
References
(Earliest) J:5987 Lush IE, et al., Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res. 1978 Apr;31(2):177-86
(Latest) J:204373 Megaraj V, et al., Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. Carcinogenesis. 2014 Jan;35(1):131-7
All references(56)
Other
accession IDs
MGD-MRK-2050, MGD-MRK-2299, MGD-MRK-2314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory