Cyp2a5
Gene Detail

Symbol Name ID

Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 MGI:88597

Synonyms

Coh

Feature Type

protein coding gene

Genetic Map

Chromosome 7

15.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr7:26835305-26843548 bp, + strand From VEGA annotation of GRCm38   8244 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:85917  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 2 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2a5

Human homologs

Human Homolog		CYP2A13, cytochrome P450, family 2, subfamily A, polypeptide 13
NCBI Gene ID		1553
neXtProt AC		NX_Q16696
Human Synonyms		CPAD, CYP2A, CYPIIA13
Human Chr (Location)		19q13.2; chr19:41594356-41602100 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	cellular response to cadmium ion, heme metabolic process
Function	heme binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (113)    Tissues (96)    Images (18)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	113

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(4) cDNA(15)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000036784 (Evidence)
Ensembl Gene Model	ENSMUSG00000005547 (Evidence)
Entrez Gene	13087 (Evidence)
Consensus CDS Project	CCDS21008.1
International Mouse Knockout Project Status	Cyp2a5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036784	VEGA Gene Model | MGI Sequence Detail	8244	C57BL/6J
transcript	OTTMUST00000094406	VEGA | MGI Sequence Detail	2013	Not Applicable
polypeptide	OTTMUSP00000052492	VEGA | MGI Sequence Detail	494	Not Applicable

All sequences(40) RefSeq(4)

Polymorphisms

RFLP(4) : SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000006221	cytochrome P450 2A5

References

(Earliest) J:5987 Lush IE, et al., Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res. 1978 Apr;31(2):177-86
(Latest) J:190445 Wei Y, et al., Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model. Drug Metab Dispos. 2013 Jan;41(1):132-40
All references(53)

Other accession IDs

MGD-MRK-2050, MGD-MRK-2299, MGD-MRK-2314