Cyp24a1
Gene Detail

Symbol Name ID

Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 MGI:88593

Synonyms

24-OHase, 25-hydroxyvitamin D-24-hydroxylase, CP24, Cyp24

Feature Type

protein coding gene

Genetic Map

Chromosome 2

91.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:170482708-170497145 bp, - strand From VEGA annotation of GRCm38   14438 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp24a1

Human homologs

Human Homolog		CYP24A1, cytochrome P450, family 24, subfamily A, polypeptide 1
NCBI Gene ID		1591
neXtProt AC		NX_Q07973
Human Synonyms		CP24, CYP24, HCAI, P450-CC24
Human Chr (Location)		20q13; chr20:52769988-52790516 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CYP24A1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruption of this gene suffer a 50% mortality rate between birth and weaning. abnormalities are seen in the development of membranous bones.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	oxidation-reduction process, response to vitamin D, ...
Component	mitochondrion
Function	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (120)    Tissues (108)    Images (2)
Theiler Stages: 10, 18, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	26

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019774 (Evidence)
Ensembl Gene Model	ENSMUSG00000038567 (Evidence)
Entrez Gene	13081 (Evidence)
UniGene	6575
DFCI	TC1575691
DoTS	DT.99863334
NIA Mouse Gene Index	U023713
EC	1.14.13.126
Consensus CDS Project	CCDS17122.1
International Mouse Knockout Project Status	Cyp24a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019774	VEGA Gene Model | MGI Sequence Detail	14438	C57BL/6J
transcript	OTTMUST00000038488	VEGA | MGI Sequence Detail	3560	Not Applicable
polypeptide	OTTMUSP00000017229	VEGA | MGI Sequence Detail	514	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002949	Cytochrome P450, E-class, CYP24A, mitochondrial
InterPro	IPR002401	Cytochrome P450, E-class, group I
Protein Ontology	PR:000006106	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

References

(Earliest) J:20133 Malas S, et al., The genes for endothelin 3, vitamin d 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. Mamm Genome. 1994;5:577-579
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)

Other accession IDs

MGD-MRK-2310