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Cyp24a1
Gene Detail
 Symbol
Name
ID
Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
MGI:88593
Synonyms 24-OHase, 25-hydroxyvitamin D-24-hydroxylase, CP24, Cyp24
Feature Type protein coding gene
Genetic Map
Chromosome 2
91.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:170482708-170497145 bp, - strand
From VEGA annotation of GRCm38

  14438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp24a1

Human
homologs
Human Homolog CYP24A1, cytochrome P450, family 24, subfamily A, polypeptide 1
NCBI Gene ID 1591
neXtProt AC  NX_Q07973
Human Synonyms  CP24, CYP24, HCAI, P450-CC24
Human Chr (Location)  20q13; chr20:54153449-54173977 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP24A1
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene suffer a 50% mortality rate between birth and weaning. abnormalities are seen in the development of membranous bones.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process oxidation-reduction process, response to vitamin D, ...
Component mitochondrion
Function 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (120)    Tissues (108)    Images (2)
Theiler Stages: 10, 18, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 94
RT-PCR 26
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019774 (Evidence)
Ensembl Gene ModelENSMUSG00000038567 (Evidence)
Entrez Gene13081 (Evidence)
UniGene6575
DFCITC1575691
DoTSDT.99863334
NIA Mouse Gene IndexU023713
EC1.14.13.126
Consensus CDS ProjectCCDS17122.1
International Mouse Knockout Project StatusCyp24a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019774 VEGA Gene Model | MGI Sequence Detail 14438 C57BL/6J ±  kb
transcript OTTMUST00000038488 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000017229 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002949 Cytochrome P450, E-class, CYP24A, mitochondrial
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006106 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
References (Earliest) J:20133 Malas S, et al., The genes for endothelin 3, vitamin d 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. Mamm Genome. 1994;5:577-579
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)
Other
accession IDs
MGD-MRK-2310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory