About   Help   FAQ
Cyp24a1
Gene Detail
Symbol

Name
ID
Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
MGI:88593
Synonyms
24-OHase, 25-hydroxyvitamin D-24-hydroxylase, CP24, Cyp24
Feature Type
protein coding gene
Genetic Map
Chromosome 2
91.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:170482708-170497145 bp, - strand
From VEGA annotation of GRCm38

  14438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP24A1
Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp24a1

Human
homologs
CYP24A1, cytochrome P450, family 24, subfamily A, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1591
neXtProt AC: NX_Q07973

Human Synonyms: CP24, CYP24, HCAI, P450-CC24

Human Chr (Location): 20q13; chr20:54153449-54173985 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP24A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene suffer a 50% mortality rate between birth and weaning. abnormalities are seen in the development of membranous bones.
 
Interactions
Cyp24a1 interacts with 233 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (120)    Tissues (109)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 26
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cyp24a1    NEW 
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019774 (Evidence)
Ensembl Gene Model ENSMUSG00000038567 (Evidence)
Entrez Gene 13081 (Evidence)
UniGene 6575
DFCI TC1575691
DoTS DT.99863334
NIA Mouse Gene Index U023713
EC 1.14.13.126
Consensus CDS Project CCDS17122.1
International Mouse Phenotyping Consortium Status Cyp24a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019774 VEGA Gene Model | MGI Sequence Detail 14438 C57BL/6J ±  kb
transcript OTTMUST00000038488 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000017229 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002949 Cytochrome P450, E-class, CYP24A, mitochondrial
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006106 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
References
(Earliest) J:20133 Malas S, et al., The genes for endothelin 3, vitamin d 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. Mamm Genome. 1994;5:577-579
(Latest) J:211926 Ohata Y, et al., Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014 Jul;29(7):1627-38
All references(48)
Other
accession IDs
MGD-MRK-2310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory