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Cyp21a1
Gene Detail
 Symbol
Name
ID
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
MGI:88591
Synonyms 21-hydroxylase, 21OH, 21-OH, 21OHA, Cyp21, Oh21-1, Oh21-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr17:34801348-34804561 bp, - strand
From VEGA annotation of GRCm38

  3214 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp21a1

Human
homologs
Human Homolog CYP21A2, cytochrome P450, family 21, subfamily A, polypeptide 2
NCBI Gene ID 1589
neXtProt AC  NX_P08686
Human Synonyms  CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
Human Chr (Location)  6p21.3; chr6:32035476-32041670 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP21A2
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
 
An 80kb deletion including Cyp21a1 is found in mice with the H2 haplotype aw18. Homozygotes are lethal, but can be rescued with a Cyp21a1 transgene.
 
Interactions
Cyp21a1 interacts with 60 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process C21-steroid hormone biosynthetic process, mineralocorticoid biosynthetic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function heme binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (106)    Tissues (106)    Images (1)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(22) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037259 (Evidence)
Ensembl Gene ModelENSMUSG00000024365 (Evidence)
Entrez Gene13079 (Evidence)
UniGene440407
DFCITC1598747, TC1708586
DoTSDT.91565167
EC1.14.99.10
Consensus CDS ProjectCCDS28658.1
International Mouse Knockout Project StatusCyp21a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037259 VEGA Gene Model | MGI Sequence Detail 3214 C57BL/6J ±  kb
transcript OTTMUST00000096082 VEGA | MGI Sequence Detail 2058 Not Applicable 
polypeptide OTTMUSP00000053643 VEGA | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(3) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(52 from dbSNP Build 137)    SNPs within 2kb including multiple locations(134)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006218 steroid 21-hydroxylase
References (Earliest) J:7260 Chaplin DD, et al., Molecular map of the murine S region. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6947-51
(Latest) J:197548 Pihlajoki M, et al., Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67
All references(79)
Other
accession IDs
MGD-MRK-1000, MGD-MRK-13021, MGD-MRK-2305, MGD-MRK-2307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory