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Cyp21a1 Gene Detail
Summary
  • Symbol
    Cyp21a1
  • Name
    cytochrome P450, family 21, subfamily a, polypeptide 1
  • Synonyms
    21-hydroxylase, 21OH, 21-OH, 21OHA, Cyp21, Oh21-1, Oh21-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88591
    NCBI Gene: 13079
  • Gene Overview
    MyGene.info: CYP21A2
Location & Maps
more
  • Sequence Map
    Chr17:34801348-34804561 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3214 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CYP21A2, cytochrome P450 family 21 subfamily A member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYP21A2, cytochrome P450 family 21 subfamily A member 2
    Orthology source: HomoloGene
  • Synonyms
    CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
  • Links
    NCBI Gene ID: 1589
    neXtProt AC: NX_P08686

  • Chr Location
    6p21.3; chr6:32038316-32041670 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CYP21A2 associations

Human Disease Mouse Models
       Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency   OMIM: 201910
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    4
  • Transgenic
    4
  • Incidental Mutations
An 80kb deletion including Cyp21a1 is found in mice with the H2 haplotype aw18. Homozygotes are lethal, but can be rescued with a Cyp21a1 transgene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037259 VEGA Gene Model | MGI Sequence Detail 3214 C57BL/6J ±  kb
transcript OTTMUST00000096082 VEGA | MGI Sequence Detail 2058 Not Applicable  
polypeptide OTTMUSP00000053643 VEGA | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 39
    Genomic 22
    cDNA 10
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1000, MGD-MRK-13021, MGD-MRK-2305, MGD-MRK-2307
References
more
  • Summaries
    All 77
    Developmental Gene Expression 24
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:7260 Chaplin DD, et al., Molecular map of the murine S region. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6947-51
  • Latest
    J:224628 Tevosian SG, et al., Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology. 2015 Jul;156(7):2503-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory