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Cyp21a1 Gene Detail
Summary
  • Symbol
    Cyp21a1
  • Name
    cytochrome P450, family 21, subfamily a, polypeptide 1
  • Synonyms
    21-hydroxylase, 21OH, 21-OH, 21OHA, Cyp21, Oh21-1, Oh21-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88591
    NCBI Gene: 13079
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34801348-34804426 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.36 cM
  • Mapping Data
    29 experiments
Strain
Comparison
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  • Strain Annotations
    11
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88591
protein coding gene Chr17:34801348-34804561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023589
protein coding gene Chr17:34905165-34908344 (-)
A/J MGP_AJ_G0023550
protein coding gene Chr17:33765241-33766082 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023995
protein coding gene Chr17:36225608-36226847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021473
protein coding gene Chr17:31517429-31520643 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023292
protein coding gene Chr17:37653530-37762724 (-)
DBA/2J MGP_DBA2J_G0023421
protein coding gene Chr17:32929264-32932570 (-)
FVB/NJ MGP_FVBNJ_G0023387
protein coding gene Chr17:32825670-32915013 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0023411
protein coding gene Chr17:36609983-36613242 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022380
protein coding gene Chr17:32469030-32472181 (-)
WSB/EiJ MGP_WSBEiJ_G0022875
protein coding gene Chr17:34557099-34563457 (-)



Homology
more
  • Human Ortholog
    CYP21A1P, cytochrome P450 family 21 subfamily A member 1, pseudogene
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYP21A1P, cytochrome P450 family 21 subfamily A member 1, pseudogene
    Orthology source: HGNC
  • Synonyms
    CYP21A, CYP21P, P450c21A
  • Links
    NCBI Gene ID: 1590

  • Chr Location
    6p21.33; chr6:32005636-32008909 (+)  GRCh38.p7

  • Human Ortholog
    CYP21A2, cytochrome P450 family 21 subfamily A member 2
    Orthology source: HomoloGene
  • Synonyms
    CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
  • Links
    NCBI Gene ID: 1589
    neXtProt AC: NX_P08686
    UniProt: P08686

  • Chr Location
    6p21.33; chr6:32038316-32041670 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
An 80kb deletion including Cyp21a1 is found in mice with the H2 haplotype aw18. Homozygotes are lethal, but can be rescued with a Cyp21a1 transgene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13079 NCBI Gene Model | MGI Sequence Detail 3079 C57BL/6J ±  kb
transcript NM_009995 RefSeq | MGI Sequence Detail 1939 C57BL/6  
polypeptide P03940 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 41
    Genomic 23
    cDNA 11
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1000, MGD-MRK-13021, MGD-MRK-2305, MGD-MRK-2307
References
more
  • Summaries
    All 91
    Developmental Gene Expression 26
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:7260 Chaplin DD, et al., Molecular map of the murine S region. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6947-51
  • Latest
    J:244906 Berthon A, et al., Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum Mol Genet. 2017 Sep 15;26(18):3495-3507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory