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Cyp21a1
Gene Detail
Symbol

Name
ID
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
MGI:88591
Synonyms
21-hydroxylase, 21OH, 21-OH, 21OHA, Cyp21, Oh21-1, Oh21-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr17:34801348-34804561 bp, - strand
From VEGA annotation of GRCm38

  3214 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP21A2
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp21a1

Human
homologs
CYP21A2, cytochrome P450, family 21, subfamily A, polypeptide 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1589
neXtProt AC: NX_P08686

Human Synonyms: CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B

Human Chr (Location): 6p21.3; chr6:32038316-32041670 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP21A2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
 
An 80kb deletion including Cyp21a1 is found in mice with the H2 haplotype aw18. Homozygotes are lethal, but can be rescued with a Cyp21a1 transgene.
 
Interactions
Cyp21a1 interacts with 59 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (21 records)
Data Summary: Results (162)    Tissues (116)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 94
Western blot 4
RT-PCR 62
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(22) cDNA(10) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037259 (Evidence)
Ensembl Gene Model ENSMUSG00000024365 (Evidence)
Entrez Gene 13079 (Evidence)
UniGene 440407
DFCI TC1598747, TC1708586
DoTS DT.91565167
EC 1.14.99.10
Consensus CDS Project CCDS28658.1
International Mouse Phenotyping Consortium Status Cyp21a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037259 VEGA Gene Model | MGI Sequence Detail 3214 C57BL/6J ±  kb
transcript OTTMUST00000096082 VEGA | MGI Sequence Detail 2058 Not Applicable 
polypeptide OTTMUSP00000053643 VEGA | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(52 from dbSNP Build 137)    SNPs within 2kb including multiple locations(134)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006218 steroid 21-hydroxylase
References
(Earliest) J:7260 Chaplin DD, et al., Molecular map of the murine S region. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6947-51
(Latest) J:210262 Boucher E, et al., Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20alpha-hydroxysteroid dehydrogenase in the mouse lung. BMC Res Notes. 2014;7:119
All references(75)
Other
accession IDs
MGD-MRK-1000, MGD-MRK-13021, MGD-MRK-2305, MGD-MRK-2307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory