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Cyp11b1
Gene Detail
Symbol

Name
ID
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
MGI:88583
Synonyms
Cyp11b, Cyp11b-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:74834125-74841643 bp, - strand
From VEGA annotation of GRCm38

  7519 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:106948  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CYP11B2
Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11b1

Human
homologs
CYP11B2, cytochrome P450, family 11, subfamily B, polypeptide 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1585
neXtProt AC: NX_P19099

Human Synonyms: ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P450C18, P-450C18

Human Chr (Location): 8q21-q22; chr8:142910558-142917862 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CYP11B2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Cyp11b1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.
 
Phenotype Images(4)
Interactions
Cyp11b1 interacts with 138 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (121)    Tissues (107)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 104
RT-PCR 16
cDNA source data(10)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(12) Primer pair(6) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000045157 (Evidence)
Ensembl Gene Model ENSMUSG00000075604 (Evidence)
Entrez Gene 110115 (Evidence)
UniGene 322606
DoTS DT.55211275
NIA Mouse Gene Index U138144
Consensus CDS Project CCDS27535.1
International Mouse Phenotyping Consortium Status Cyp11b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045157 VEGA Gene Model | MGI Sequence Detail 7519 C57BL/6J ±  kb
transcript OTTMUST00000118662 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000066226 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(3) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(57 from dbSNP Build 137)    SNPs within 2kb including multiple locations(61)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002399 Cytochrome P450, mitochondrial
References
(Earliest) J:22670 Wong M, et al., The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. J Biol Chem. 1989 Aug 5;264(22):12867-71
(Latest) J:222045 Padua MB, et al., Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
All references(52)
Other
accession IDs
MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory