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Cyp11b1
Gene Detail
 Symbol
Name
ID
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
MGI:88583
Synonyms Cyp11b, Cyp11b-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:74834892-74841643 bp, - strand
From NCBI annotation of GRCm38

  6752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:106948  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11b1

Human
homologs
Human Homolog CYP11B2, cytochrome P450, family 11, subfamily B, polypeptide 2
NCBI Gene ID 1585
neXtProt AC  NX_P19099
Human Synonyms  ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P450C18, P-450C18
Human Chr (Location)  8q21-q22; chr8:142910559-142917843 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYP11B2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Cyp11b1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.
 
Phenotype Images(2)
Interactions
Cyp11b1 interacts with 138 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process aldosterone biosynthetic process, C21-steroid hormone biosynthetic process, ...
Component mitochondrion
Function corticosterone 18-monooxygenase activity, heme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (102)    Tissues (98)    Images (1)
Theiler Stages: 22, 23, 24, 25, 26
Assay TypeResults
RNA in situ 102
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000075604 (Evidence)
Entrez Gene110115 (Evidence)
UniGene322606
DoTSDT.55211275
NIA Mouse Gene IndexU138144
Consensus CDS ProjectCCDS27535.1
International Mouse Knockout Project StatusCyp11b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 110115 NCBI Gene Model | MGI Sequence Detail 6752 C57BL/6J ±  kb
transcript NM_001033229 RefSeq | MGI Sequence Detail 2398 C57BL/6 
polypeptide NP_001028401 RefSeq | MGI Sequence Detail 501 C57BL/6 

For the selected sequences
All sequences(19) RefSeq(3) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(56 from dbSNP Build 137)    SNPs within 2kb including multiple locations(60)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002399 Cytochrome P450, mitochondrial
References (Earliest) J:22670 Wong M, et al., The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. J Biol Chem. 1989 Aug 5;264(22):12867-71
(Latest) J:199581 Bohnenpoll T, et al., Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev Biol. 2013 Aug 1;380(1):25-36
All references(51)
Other
accession IDs
MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory