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Cyp11b1 Gene Detail
Summary
  • Symbol
    Cyp11b1
  • Name
    cytochrome P450, family 11, subfamily b, polypeptide 1
  • Synonyms
    Cyp11b, Cyp11b-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88583
    NCBI Gene: 110115
Location & Maps
more
  • Sequence Map
    Chr15:74834125-74841643 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7519 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
    Orthology source: HGNC
  • Synonyms
    CPN1, CYP11B, FHI, P450C11
  • Links
    NCBI Gene ID: 1584
    neXtProt AC: NX_P15538

  • Chr Location
    8q21; chr8:142872354-142879846 (-)  GRCh38.p2

  • Human Ortholog
    CYP11B2, cytochrome P450 family 11 subfamily B member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P450C18, P-450C18
  • Links
    NCBI Gene ID: 1585
    neXtProt AC: NX_P19099

  • Chr Location
    8q21-q22; chr8:142910558-142917862 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cyp11b1 mouse models; 4 with human CYP11B1,CYP11B2 associations

Human Disease Mouse Models
       Adrenal Hyperplasia, Congenital, Due to Steroid 11-Beta-Hydroxylase Deficiency   OMIM: 202010 View 1 model
       Corticosterone Methyloxidase Type I Deficiency   OMIM: 203400
Corticosterone Methyloxidase Type II Deficiency   OMIM: 610600
Hyperaldosteronism, Familial, Type I; HALD1   OMIM: 103900
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Cyp11b1
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045157 VEGA Gene Model | MGI Sequence Detail 7519 C57BL/6J ±  kb
transcript OTTMUST00000118662 VEGA | MGI Sequence Detail 3165 Not Applicable  
polypeptide OTTMUSP00000066226 VEGA | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001128 Cytochrome P450
    IPR017972 Cytochrome P450, conserved site
    IPR002399 Cytochrome P450, mitochondrial
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 12
    Primer pair 6
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249
References
more
  • Summaries
    All 52
    Developmental Gene Expression 21
    Diseases 2
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:22670 Wong M, et al., The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. J Biol Chem. 1989 Aug 5;264(22):12867-71
  • Latest
    J:224628 Tevosian SG, et al., Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology. 2015 Jul;156(7):2503-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory