Cyp11b1
Gene Detail

Symbol Name ID

Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 MGI:88583

Synonyms

Cyp11b, Cyp11b-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:74834892-74841643 bp, - strand From NCBI annotation of GRCm38   6752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic; hamster, golden; pig, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Cyp11b1 ± 2 cM)

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11b1

Human ortholog

CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 NCBI Gene ID 1584
Human Synonyms: CPN1, CYP11B, FHI, P450C11
Human Chr8:143953773-143961236 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CYP11B1 (2)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	aldosterone biosynthetic process, C21-steroid hormone biosynthetic process, ...
Component	integral to endoplasmic reticulum membrane, mitochondrion
Function	corticosterone 18-monooxygenase activity, metal ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (102)    Tissues (98)    Images (1)
Theiler Stages: 22, 23, 24, 25, 26

Assay Type	Results
RNA in situ	102

cDNA source data(10)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000075604 (Evidence)
Entrez Gene	110115 (Evidence)
UniGene	322606
DoTS	DT.55211275
NIA Mouse Gene Index	U138144
Consensus CDS Project	CCDS27535.1
International Mouse Knockout Project Status	Cyp11b1

Sequences

Length	Strain/Species
genomic	110115	NCBI Gene Model | MGI Sequence Detail	6752	C57BL/6J
transcript	NM_001033229	RefSeq | MGI Sequence Detail	2398	C57BL/6
polypeptide	NP_001028401	RefSeq | MGI Sequence Detail	501	C57BL/6

All sequences(19) RefSeq(3) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002399	Cytochrome P450, mitochondrial

References

(Earliest) J:22670 Wong M, et al., The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. J Biol Chem. 1989 Aug 5;264(22):12867-71
(Latest) J:189572 Huang CC, et al., Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice. Mol Cell Endocrinol. 2012 Sep 25;361(1-2):165-71
All references(47)

Other accession IDs

MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249