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Cycs Gene Detail
Summary
  • Symbol
    Cycs
  • Name
    cytochrome c, somatic
  • Feature Type
    protein coding gene
  • IDs
    MGI:88578
    NCBI Gene: 13063
  • Gene Overview
    MyGene.info: CYCS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50562563-50566474 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.32 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88578
protein coding gene Chr6:50562563-50566538 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030730
protein coding gene Chr6:49680640-49687724 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0030626
protein coding gene Chr6:49022771-49032843 (-)
BALB/cJ MGP_BALBcJ_G0030711
protein coding gene Chr6:47709990-47713561 (-)
C3H/HeJ MGP_C3HHeJ_G0030424
protein coding gene Chr6:49051274-49055249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031166
protein coding gene Chr6:50797921-50801229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028373
protein coding gene Chr6:44970428-44974642 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030548
protein coding gene Chr6:47277603-47282533 (-)
FVB/NJ MGP_FVBNJ_G0030500
protein coding gene Chr6:46915758-46919765 (-)
LP/J MGP_LPJ_G0030633
protein coding gene Chr6:49640382-49644355 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030534
protein coding gene Chr6:55646536-55652007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031195
protein coding gene Chr6:48947734-48951813 (-)
PWK/PhJ MGP_PWKPhJ_G0029540
protein coding gene Chr6:46854251-46858109 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYCS, cytochrome c, somatic
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYCS, cytochrome c, somatic
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYC, HCS, THC4
  • Links
    NCBI Gene ID: 54205
    neXtProt AC: NX_P99999
    UniProt: P99999

  • Chr Location
    7p15.3; chr7:25118651-25125361 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CYCS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die at midgestation. By E8.5, homozygous null embryos exhibit a strikingly reduced size and are developmentally retarded.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13063 NCBI Gene Model | MGI Sequence Detail 3912 C57BL/6J ±  kb
    transcript NM_007808 RefSeq | MGI Sequence Detail 3154 C57BL/6  
    polypeptide P62897 UniProt | EBI | MGI Sequence Detail 105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 233
      Genomic 2
      cDNA 230
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2287
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 18
      Gene Ontology 16
      Phenotypes 21
    • Earliest
      J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
    • Latest
      J:266346 Yamada S, et al., Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system. J Comp Neurol. 2018 Sep 1;526(13):2099-2114

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory