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Cycs
Gene Detail
 Symbol
Name
ID
Cycs
cytochrome c, somatic
MGI:88578
Feature Type protein coding gene
Genetic Map
Chromosome 6
24.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:50562563-50566538 bp, - strand
From VEGA annotation of GRCm38

  3976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133055  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cycs

Human
homologs
Human Homolog CYCS, cytochrome c, somatic
NCBI Gene ID 54205
neXtProt AC  NX_P99999
Human Synonyms  CYC, HCS, THC4
Human Chr (Location)  7p15.3; chr7:25118651-25125361 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYCS
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted mutation die at midgestation. By E8.5, homozygous null embryos exhibit a strikingly reduced size and are developmentally retarded.
 
Interactions
Cycs interacts with 295 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, apoptotic DNA fragmentation, ...
Component cytosol, mitochondrion, ...
Function electron carrier activity, electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (167)    Tissues (45)    Images (29)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 150
Western blot 8
RT-PCR 9
cDNA source data(229)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(232) Genomic(2) cDNA(229) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000034264 (Evidence)
Ensembl Gene ModelENSMUSG00000063694 (Evidence)
Entrez Gene13063 (Evidence)
UniGene35389
DFCITC1573177, TC1669169
DoTSDT.101277138, DT.102540369, DT.496226
NIA Mouse Gene IndexU019315, U047743, U060791, U069135, U093555
Consensus CDS ProjectCCDS20131.1
International Mouse Knockout Project StatusCycs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034264 VEGA Gene Model | MGI Sequence Detail 3976 C57BL/6J ±  kb
transcript OTTMUST00000087067 VEGA | MGI Sequence Detail 3123 Not Applicable 
polypeptide OTTMUSP00000047209 VEGA | MGI Sequence Detail 105 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2)
Polymorphisms RFLP(2) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000002321 cytochrome c, somatic
References (Earliest) J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
(Latest) J:210495 Josephs TM, et al., Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release. Biochem J. 2014 Mar 1;458(2):259-65
All references(70)
Other
accession IDs
MGD-MRK-2287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory