Cycs
Gene Detail

Symbol Name ID

Cycs cytochrome c, somatic MGI:88578

Feature Type

protein coding gene

Genetic Map

Chromosome 6

24.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:50562563-50566538 bp, - strand From VEGA annotation of GRCm38   3976 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133055  Vertebrate Homology Class
1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Cycs

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for a targeted mutation die at midgestation. By E8.5, homozygous null embryos exhibit a strikingly reduced size and are developmentally retarded.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, apoptotic process, ...
Component	cytosol, mitochondrion
Function	electron carrier activity, heme binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (142)    Tissues (20)    Images (27)
Theiler Stages: 23, 26, 28

Assay Type	Results
RNA in situ	125
Western blot	8
RT-PCR	9

cDNA source data(231)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(234) Genomic(2) cDNA(231) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000034264 (Evidence)
Ensembl Gene Model	ENSMUSG00000063694 (Evidence)
Entrez Gene	13063 (Evidence)
UniGene	35389
DFCI	TC1573177, TC1669169
DoTS	DT.101277138, DT.102540369, DT.496226
NIA Mouse Gene Index	U019315, U047743, U060791, U069135, U093555
Consensus CDS Project	CCDS20131.1
International Mouse Knockout Project Status	Cycs

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034264	VEGA Gene Model | MGI Sequence Detail	3976	C57BL/6J
transcript	OTTMUST00000087067	VEGA | MGI Sequence Detail	3123	Not Applicable
polypeptide	OTTMUSP00000047209	VEGA | MGI Sequence Detail	105	Not Applicable

All sequences(36) RefSeq(2)

Polymorphisms

RFLP(2) : SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000002321	cytochrome c, somatic

References

(Earliest) J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
(Latest) J:185833 Fernandes R, et al., NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod. 2012;86(5):138, 1-10
All references(62)

Other accession IDs

MGD-MRK-2287