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Cux1
Gene Detail
 Symbol
Name
ID
Cux1
cut-like homeobox 1
MGI:88568
Synonyms CDP, Cutl1, Cux, Cux-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
75.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:136248135-136567490 bp, - strand
From VEGA annotation of GRCm38

  319356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Cux1
Alleles
and
phenotypes
All alleles(32) : Gene trapped(27) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process auditory receptor cell differentiation, intra-Golgi vesicle-mediated transport, ...
Component cytoplasm, Golgi apparatus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (138 records)
Data Summary: Results (310)    Tissues (234)    Images (48)
Theiler Stages: 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 20
RNA in situ 212
Northern blot 26
Western blot 36
RT-PCR 16
cDNA source data(185)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(191) Genomic(1) cDNA(187) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000040141 (Evidence)
Ensembl Gene ModelENSMUSG00000029705 (Evidence)
Entrez Gene13047 (Evidence)
UniGene320317
DFCITC1576010, TC1585756, TC1585776, TC1587379, TC1675348, TC1681453, TC1689455, TC1710747
DoTSDT.101295741, DT.101391545, DT.101391547, DT.103570939, DT.494142, DT.522359, DT.55161651, DT.55229903, DT.91341063, DT.91374488
NIA Mouse Gene IndexU026833
Consensus CDS ProjectCCDS39328.1, CCDS57391.1, CCDS71684.1, CCDS71685.1
International Mouse Knockout Project StatusCux1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040141 VEGA Gene Model | MGI Sequence Detail 319356 C57BL/6J ±  kb
transcript OTTMUST00000104306 VEGA | MGI Sequence Detail 4882 Not Applicable 
polypeptide OTTMUSP00000058365 VEGA | MGI Sequence Detail 1517 Not Applicable 

For the selected sequences
All sequences(157) RefSeq(26) UniProt(20)
Polymorphisms RFLP(1) : SNPs within 2kb(658 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012955 CASP, C-terminal
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003350 Homeodomain protein CUT
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
References (Earliest) J:11951 Andres V, et al., Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development. 1992 Oct;116(2):321-34
(Latest) J:206964 Wu X, et al., A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior. J Neurosci. 2014 Jan 22;34(4):1510-22
All references(198)
Other
accession IDs
MGD-MRK-2253, MGI:2140722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory