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Cux1
Gene Detail
Symbol

Name
ID
Cux1
cut-like homeobox 1
MGI:88568
Synonyms
CDP, Cutl1, Cux, Cux-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:136248135-136567490 bp, - strand
From VEGA annotation of GRCm38

  319356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Cux1
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(27) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters.
 
Interactions
Cux1 interacts with 369 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process auditory receptor cell differentiation, intra-Golgi vesicle-mediated transport, ...
Component cytoplasm, Golgi apparatus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (141 records)
Data Summary: Results (338)    Tissues (234)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 248
Northern blot 23
Western blot 36
RT-PCR 9
cDNA source data(185)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(192) Genomic(1) cDNA(188) Primer pair(3)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040141 VEGA Gene Model | MGI Sequence Detail 319356 C57BL/6J ±  kb
transcript OTTMUST00000104306 VEGA | MGI Sequence Detail 4882 Not Applicable 
polypeptide OTTMUSP00000058365 VEGA | MGI Sequence Detail 1517 Not Applicable 

For the selected sequences
All sequences(156) RefSeq(26) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(658 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012955 CASP, C-terminal
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003350 Homeodomain protein CUT
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
References
(Earliest) J:11951 Andres V, et al., Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development. 1992 Oct;116(2):321-34
(Latest) J:209618 DeBoer EM, et al., Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior. J Neurosci. 2014 Mar 5;34(10):3674-86
All references(201)
Other
accession IDs
MGD-MRK-2253, MGI:2140722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory