About   Help   FAQ
Cux1
Gene Detail
Symbol

Name
ID
Cux1
cut-like homeobox 1
MGI:88568
Synonyms
CDP, Cutl1, Cux, Cux-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:136248135-136567490 bp, - strand
From VEGA annotation of GRCm38

  319356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: CUX1
Gene Tree: Cux1
Human
homologs
CUX1, cut-like homeobox 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 1523
neXtProt AC: NX_P39880, NX_Q13948

Human Synonyms: CASP, CDP, CDP1, CDP/Cut, Clox, COY1, CUTL1, CUX, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75

Human Chr (Location): 7q22.1; chr7:101815904-102283958 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(27) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters.
 
Interactions
Cux1 interacts with 369 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process auditory receptor cell differentiation, intra-Golgi vesicle-mediated transport, ...
Component cytoplasm, Golgi apparatus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (172 records)
Data Summary: Results (386)    Tissues (271)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 290
Northern blot 29
Western blot 36
RT-PCR 9
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cux1 ; ZFIN cux1b    NEW 
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(33) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000040141 (Evidence)
Ensembl Gene Model ENSMUSG00000029705 (Evidence)
Entrez Gene 13047 (Evidence)
Consensus CDS Project CCDS39328.1, CCDS57391.1, CCDS71684.1, CCDS71685.1
International Mouse Phenotyping Consortium Status Cux1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040141 VEGA Gene Model | MGI Sequence Detail 319356 C57BL/6J ±  kb
transcript OTTMUST00000104306 VEGA | MGI Sequence Detail 4882 Not Applicable 
polypeptide OTTMUSP00000058365 VEGA | MGI Sequence Detail 1517 Not Applicable 

For the selected sequences
All sequences(141) RefSeq(26) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(658 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012955 CASP, C-terminal
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003350 Homeodomain protein CUT
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
References
(Earliest) J:11951 Andres V, et al., Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development. 1992 Oct;116(2):321-34
(Latest) J:222255 Knock E, et al., The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13
All references(224)
Other
accession IDs
MGD-MRK-2253, MGI:2140722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory