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Ctsl Gene Detail
Summary
  • Symbol
    Ctsl
  • Name
    cathepsin L
  • Synonyms
    1190035F06Rik, Cat L, major excreted protein, MEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:88564
    NCBI Gene: 13039
  • Gene Overview
    MyGene.info: CTSV
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:64361890-64370748 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8859 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CTSV, cathepsin V
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSV, cathepsin V
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CATL2, CTSL2, CTSU
  • Links
    NCBI Gene ID: 1515
    neXtProt AC: NX_O60911
    UniProt: O60911

  • Chr Location
    9q22.33; chr9:97029677-97039643 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 76699
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;2 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CTSV
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ctsl mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    108 phenotypes from 6 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    6 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for mutant alleles may show partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13039 NCBI Gene Model | MGI Sequence Detail 8859 C57BL/6J ±  kb
    transcript NM_009984 RefSeq | MGI Sequence Detail 3509 C57BL/6  
    polypeptide P06797 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      174 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 873
      cDNA 867
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2248, MGD-MRK-9874, MGI:1338075, MGI:2443888, MGI:95581
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 13
      Phenotypes 87
    • Earliest
      J:15332 Green EL, The genetics of a new hair deficiency, furless, in the house mouse. J Hered. 1954;45:115-18
    • Latest
      J:258062 Xu S, et al., Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-kappaB pathways. Neurobiol Aging. 2018 Feb;62:159-167

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory