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Ctsl Gene Detail
Summary
  • Symbol
    Ctsl
  • Name
    cathepsin L
  • Synonyms
    1190035F06Rik, Cat L, major excreted protein, MEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:88564
    NCBI Gene: 13039
  • Gene Overview
    MyGene.info: CTSV
Location & Maps
more
  • Sequence Map
    Chr13:64363214-64370306 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7093 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CTSV, cathepsin V
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSV, cathepsin V
    Orthology source: HomoloGene
  • Synonyms
    CATL2, CTSL2, CTSU
  • Links
    NCBI Gene ID: 1515
    neXtProt AC: NX_O60911

  • Chr Location
    9q22.2; chr9:97029677-97039643 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 76699
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;2 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CTSV
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 4 alleles in 9 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ctsl
  • Incidental Mutations
Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules andreduced sperm production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021477 Ensembl Gene Model | MGI Sequence Detail 7093 C57BL/6J ±  kb
transcript ENSMUST00000021933 Ensembl | MGI Sequence Detail 1971 Not Applicable  
polypeptide ENSMUSP00000021933 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    150 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 870
    cDNA 865
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-2248, MGD-MRK-9874, MGI:1338075, MGI:2443888, MGI:95581
References
more
  • Summaries
    All 146
    Developmental Gene Expression 19
    Gene Ontology 14
    Phenotypes 80
  • Earliest
    J:15332 Green EL, The genetics of a new hair deficiency, furless, in the house mouse. J Hered. 1954;45:115-18
  • Latest
    J:229244 Brindle NR, et al., Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS One. 2015;10(4):e0120348

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory