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Ctrb1
Gene Detail
Symbol

Name
ID
Ctrb1
chymotrypsinogen B1
MGI:88559
Synonyms
2200008D09Rik, Prt-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr8:111686510-111691010 bp, - strand
From NCBI annotation of GRCm38

  4501 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 3 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Ctrb1

Human
homologs
Human Homolog CTRB2, chymotrypsinogen B2
NCBI Gene ID 440387
neXtProt AC  NX_Q6GPI1
Human Chr (Location)  16q23.1; chr16:75204096-75207174 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ctrb1 interacts with 10 markers (Mir33, Mir137, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process digestion, positive regulation of apoptotic process, ...
Component cytoplasm, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (17)    Tissues (3)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
RT-PCR 3
cDNA source data(2151)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2153) cDNA(2152) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031957 (Evidence)
Entrez Gene66473 (Evidence)
UniGene34374
DFCITC1573641
DoTSDT.102540027, DT.94232982, DT.94233035, DT.97393043, DT.99871581
NIA Mouse Gene IndexU030268
EC3.4.21.1
Consensus CDS ProjectCCDS22679.1
International Mouse Knockout Project StatusCtrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66473 NCBI Gene Model | MGI Sequence Detail 4501 C57BL/6J ±  kb
transcript NM_025583 RefSeq | MGI Sequence Detail 887 C57BL/6 
polypeptide Q9CR35 UniProt | EBI | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000006018 chymotrypsinogen B
Graphical View of Protein Domain Structure
References
(Earliest) J:5539 Watanabe T, et al., Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus). Biochem Genet. 1974 Nov;12(5):419-28
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(50)
Other
accession IDs
MGD-MRK-13634, MGD-MRK-2243, MGI:1913723, MGI:2138990

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory