Ctrb1
Gene Detail

Symbol Name ID

Ctrb1 chymotrypsinogen B1 MGI:88559

Synonyms

2200008D09Rik, Prt-2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr8:111686510-111691010 bp, - strand From NCBI annotation of GRCm38   4501 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Ctrb1

Human homologs

Human Homolog		CTRB2, chymotrypsinogen B2
NCBI Gene ID		440387
neXtProt AC		NX_Q6GPI1
Human Chr (Location)		16q23.1; chr16:75237994-75241072 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	digestion, positive regulation of apoptotic process, ...
Component	cytoplasm, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (3)    Images (15)
Theiler Stages: 20, 22, 23

Assay Type	Results
RNA in situ	14
RT-PCR	3

cDNA source data(2136)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(2138) cDNA(2137) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031957 (Evidence)
Entrez Gene	66473 (Evidence)
UniGene	34374
DFCI	TC1573641
DoTS	DT.102540027, DT.94232982, DT.94233035, DT.97393043, DT.99871581
NIA Mouse Gene Index	U030268
EC	3.4.21.1
Consensus CDS Project	CCDS22679.1
International Mouse Knockout Project Status	Ctrb1

Sequences

Length	Strain/Species
genomic	66473	NCBI Gene Model | MGI Sequence Detail	4501	C57BL/6J
transcript	NM_025583	RefSeq | MGI Sequence Detail	887	C57BL/6
polypeptide	Q9CR35	UniProt | EBI | MGI Sequence Detail	263	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000006018	chymotrypsinogen B

Graphical View of Protein Domain Structure

References

(Earliest) J:5539 Watanabe T, et al., Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus). Biochem Genet. 1974 Nov;12(5):419-28
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(49)

Other accession IDs

MGD-MRK-13634, MGD-MRK-2243, MGI:1913723, MGI:2138990