About   Help   FAQ
Ctrb1 Gene Detail
Summary
  • Symbol
    Ctrb1
  • Name
    chymotrypsinogen B1
  • Synonyms
    2200008D09Rik, Prt-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88559
    NCBI Gene: 66473
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111686519-111691010 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88559
protein coding gene Chr8:111686510-111691010 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034144
protein coding gene Chr8:114494982-114499468 (-)
A/J MGP_AJ_G0034124
protein coding gene Chr8:109829965-109834782 (-)
AKR/J MGP_AKRJ_G0034051
protein coding gene Chr8:113044449-113053599 (-)
BALB/cJ MGP_BALBcJ_G0034118
protein coding gene Chr8:110006972-110011982 (-)
C3H/HeJ MGP_C3HHeJ_G0033829
protein coding gene Chr8:113775930-113781796 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034638
protein coding gene Chr8:118494222-118500145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031580
protein coding gene Chr8:102800197-102805196 (-)
CAST/EiJ MGP_CASTEiJ_G0033156
protein coding gene Chr8:113404790-113409935 (-)
CBA/J MGP_CBAJ_G0033802
protein coding gene Chr8:122570341-122575767 (-)
DBA/2J MGP_DBA2J_G0033958
protein coding gene Chr8:109103790-109108443 (-)
FVB/NJ MGP_FVBNJ_G0033901
protein coding gene Chr8:108081315-108086057 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033948
protein coding gene Chr8:125423538-125428758 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034656
protein coding gene Chr8:113040679-113045197 (-)
PWK/PhJ MGP_PWKPhJ_G0032858
protein coding gene Chr8:108702267-108707647 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032698
protein coding gene Chr8:111688150-111696816 (-)
WSB/EiJ MGP_WSBEiJ_G0033272
protein coding gene Chr8:113714573-113720788 (-)



Homology
more
  • Human Ortholog
    CTRB1, chymotrypsinogen B1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CTRB1, chymotrypsinogen B1
    Orthology source: HGNC
  • Synonyms
    CTRB
  • Links
    NCBI Gene ID: 1504
    neXtProt AC: NX_P17538
    UniProt: P17538

  • Chr Location
    16q23.1; chr16:75218986-75224924 (+)  GRCh38.p7

  • Human Ortholog
    CTRB2, chymotrypsinogen B2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 440387
    neXtProt AC: NX_Q6GPI1
    UniProt: Q6GPI1

  • Chr Location
    16q23.1; chr16:75204096-75207174 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031957 Ensembl Gene Model | MGI Sequence Detail 4492 C57BL/6J ±  kb
transcript ENSMUST00000034435 Ensembl | MGI Sequence Detail 878 Not Applicable  
polypeptide ENSMUSP00000034435 Ensembl | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 2154
    cDNA 2153
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13634, MGD-MRK-2243, MGI:1913723, MGI:2138990
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:5539 Watanabe T, et al., Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus). Biochem Genet. 1974 Nov;12(5):419-28
  • Latest
    J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory