Ctrl Gene Detail

Summary

• Symbol
  Ctrl
• Name
  chymotrypsin-like
• Synonyms
  0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1

• Feature Type
  protein coding gene
• IDs
  MGI:88558
  NCBI Gene: 109660
• Gene Overview
  MyGene.info: CTRL

Location & Maps

• Sequence Map
  Chr8:105932003-105933862 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    1860 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 53.06 cM
• Mapping Data
  5 experiments

Homology

• Human Ortholog
  CTRL, chymotrypsin like

• Vertebrate Orthologs
  9

• Human Ortholog
  CTRL, chymotrypsin like
  Orthology source: HomoloGene, HGNC
• Synonyms
  CTRL1
• Links
  HGNC:2524

  NCBI Gene ID: 1506

  neXtProt AC: NX_P40313

  UniProt: P40313

  
  
• Chr Location
  16q22.1; chr16:67929570-67931875 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 37549
  1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;2 zebrafish;1 macaque, rhesus
  
• HCOP
  human homology predictions: CTRL
• Protein SuperFamily
  trypsin
• Gene Tree
  Ctrl
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  1 strains or lines available

Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  2

• External Resources
  FuncBase

Expression

• Assay Results
  24
• Tissues
  12
• cDNA Data
  5
• Literature Summary
  6

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase ctrl
  ZFIN ctrl

Interactions

• Ctrl interacts with 7 markers (Mir150, Mir706, Mir883b, ...) View All

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS22620.1

• VEGA
  OTTMUSG00000062063 (Evidence)
• Ensembl
  ENSMUSG00000031896 (Evidence)
• NCBI Gene
  109660

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000062063	VEGA Gene Model | MGI Sequence Detail	1860	C57BL/6J
transcript	OTTMUST00000151534	VEGA | MGI Sequence Detail	879	Not Applicable
polypeptide	OTTMUSP00000078585	VEGA | MGI Sequence Detail	264	Not Applicable

Polymorphisms

• SNPs within 2kb
  48 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• InterPro Domains
  IPR001314 Peptidase S1A, chymotrypsin family
  IPR009003 Peptidase S1, PA clan
  IPR001254 Serine proteases, trypsin domain
  IPR018114 Serine proteases, trypsin family, histidine active site
  IPR033116 Serine proteases, trypsin family, serine active site

Molecular
Reagents

• All nucleic 9

  cDNA 6

  Primer pair 2

  Other 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731

References

• Summaries
  All 29

  Developmental Gene Expression 6

  Gene Ontology 2
• Earliest
  J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
• Latest
  J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33