Ctrl MGI Mouse Gene Detail - MGI:88558

Symbol

Ctrl
Name

chymotrypsin-like
Synonyms

0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1

Feature Type

protein coding gene
IDs

MGI:88558
NCBI Gene: 109660
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:106658635-106660494 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.06 cM
Mapping Data

5 experiments

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88558	protein coding gene	Chr8:106658626-106660494 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034067	protein coding gene	Chr8:108255738-108257606 (-)
A/J	MGP_AJ_G0034048	protein coding gene	Chr8:103930029-103931897 (-)
AKR/J	MGP_AKRJ_G0033974	protein coding gene	Chr8:106929759-106931627 (-)
BALB/cJ	MGP_BALBcJ_G0034041	protein coding gene	Chr8:104112564-104114432 (-)
C3H/HeJ	MGP_C3HHeJ_G0033753	protein coding gene	Chr8:107672563-107674431 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034561	protein coding gene	Chr8:112228737-112230605 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031503	protein coding gene	Chr8:97062934-97064804 (-)
CAST/EiJ	MGP_CASTEiJ_G0033079	protein coding gene	Chr8:107192019-107193887 (-)
CBA/J	MGP_CBAJ_G0033726	protein coding gene	Chr8:115834349-115836217 (-)
DBA/2J	MGP_DBA2J_G0033881	protein coding gene	Chr8:103273273-103275141 (-)
FVB/NJ	MGP_FVBNJ_G0033826	protein coding gene	Chr8:102204681-102206549 (-)
LP/J	MGP_LPJ_G0033972	protein coding gene	Chr8:108471826-108473694 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033870	protein coding gene	Chr8:119025379-119027247 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034579	protein coding gene	Chr8:106897629-106899497 (-)
PWK/PhJ	MGP_PWKPhJ_G0032780	protein coding gene	Chr8:102676076-102677944 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032621	protein coding gene	Chr8:105589647-105591524 (-)
WSB/EiJ	MGP_WSBEiJ_G0033195	protein coding gene	Chr8:107584224-107586092 (-)

Human Ortholog

CTRL, chymotrypsin like

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTRL, chymotrypsin like
Synonyms

CTRL1
Links

HGNC:2524

NCBI Gene ID: 1506

neXtProt AC: NX_P40313

UniProt: P40313
Chr Location

16q22.1; chr16:67929570-67931875 (-) GRCh38.p7

Alliance of Genome Resources

Ctrl stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CTRL
Gene Tree

Ctrl

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit mice exhibit reduced intrapancreatic chymotrypsin activation but normal response to induced pancreatitis.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

696
Tissues

12
cDNA Data

7
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctrl

ZFIN ctrl

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Ctrl interacts with 7 markers (Mir150, Mir706, Mir883b, ...) View All

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS22620.1

Ensembl

ENSMUSG00000031896 (Evidence)
NCBI Gene

109660

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000031896	Ensembl Gene Model \| MGI Sequence Detail	1860	C57BL/6J	± kb

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UniProt

4 Sequences
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

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All nucleic 11

cDNA 8

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731

Summaries

All 34

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 1
Earliest

J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
Latest

J:294035 Mosztbacher D, et al., Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice. Sci Rep. 2020 Jul 16;10(1):11731

TSS for Ctrl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82718	Chr8:106660560-106660569 (-)	-71 bp
Tssr82717	Chr8:106660497-106660506 (-)	-8 bp
Tssr82716	Chr8:106660464-106660494 (-)	15 bp
Tssr82715	Chr8:106660347-106660352 (-)	144 bp
Tssr82714	Chr8:106660192-106660213 (-)	291 bp
Tssr82713	Chr8:106659860-106659891 (-)	618 bp
Tssr82712	Chr8:106659817-106659829 (-)	671 bp
Tssr82711	Chr8:106659674-106659696 (-)	809 bp
Tssr82710	Chr8:106659657-106659668 (-)	831 bp
Tssr82709	Chr8:106659649-106659656 (-)	841 bp
Tssr82708	Chr8:106659299-106659325 (-)	1,182 bp
Tssr82707	Chr8:106659226-106659236 (-)	1,263 bp
Tssr82706	Chr8:106659033-106659043 (-)	1,456 bp
Tssr82705	Chr8:106658686-106658729 (-)	1,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/10/2022 MGI 6.19