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Ctrl
Gene Detail
Symbol

Name
ID
Ctrl
chymotrypsin-like
MGI:88558
Synonyms
0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:105931994-105933862 bp, - strand
From NCBI annotation of GRCm38

  1869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Ctrl

Human
homologs
Human Homolog CTRL, chymotrypsin-like
NCBI Gene ID 1506
neXtProt AC  NX_P40313
Human Synonyms  CTRL1
Human Chr (Location)  16q22.1; chr16:67929570-67931875 (-)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
 
Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.
 
Interactions
Ctrl interacts with 7 markers (Mir150, Mir706, Mir883b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process proteolysis
Function peptidase activity, serine-type peptidase activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (12)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
RT-PCR 11
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031896 (Evidence)
Entrez Gene109660 (Evidence)
NIA Mouse Gene IndexU030188
Consensus CDS ProjectCCDS22620.1
International Mouse Knockout Project StatusCtrl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 109660 NCBI Gene Model | MGI Sequence Detail 1869 C57BL/6J ±  kb
transcript NM_023182 RefSeq | MGI Sequence Detail 919 Not Specified 
polypeptide NP_075671 RefSeq | MGI Sequence Detail 264 Not Specified 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000006021 chymotrypsin-like protease CTRL-1
References
(Earliest) J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(31)
Other
accession IDs
MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory