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Ctrl Gene Detail
Summary
  • Symbol
    Ctrl
  • Name
    chymotrypsin-like
  • Synonyms
    0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88558
    NCBI Gene: 109660
  • Gene Overview
    MyGene.info: CTRL
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105932003-105933862 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88558
 protein coding gene Chr8:105931994-105933862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034067
 protein coding gene Chr8:108255738-108257606 (-)
A/J MGP_AJ_G0034048
 protein coding gene Chr8:103930029-103931897 (-)
AKR/J MGP_AKRJ_G0033974
 protein coding gene Chr8:106929759-106931627 (-)
BALB/cJ MGP_BALBcJ_G0034041
 protein coding gene Chr8:104112564-104114432 (-)
C3H/HeJ MGP_C3HHeJ_G0033753
 protein coding gene Chr8:107672563-107674431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034561
 protein coding gene Chr8:112228737-112230605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031503
 protein coding gene Chr8:97062934-97064804 (-)
CAST/EiJ MGP_CASTEiJ_G0033079
 protein coding gene Chr8:107192019-107193887 (-)
CBA/J MGP_CBAJ_G0033726
 protein coding gene Chr8:115834349-115836217 (-)
DBA/2J MGP_DBA2J_G0033881
 protein coding gene Chr8:103273273-103275141 (-)
FVB/NJ MGP_FVBNJ_G0033826
 protein coding gene Chr8:102204681-102206549 (-)
LP/J MGP_LPJ_G0033972
 protein coding gene Chr8:108471826-108473694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033870
 protein coding gene Chr8:119025379-119027247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034579
 protein coding gene Chr8:106897629-106899497 (-)
PWK/PhJ MGP_PWKPhJ_G0032780
 protein coding gene Chr8:102676076-102677944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032621
 protein coding gene Chr8:105589647-105591524 (-)
WSB/EiJ MGP_WSBEiJ_G0033195
 protein coding gene Chr8:107584224-107586092 (-)



Homology
more
  • Human Ortholog
    CTRL, chymotrypsin like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTRL, chymotrypsin like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRL1
  • Links
    NCBI Gene ID: 1506
    neXtProt AC: NX_P40313
    UniProt: P40313

  • Chr Location
    16q22.1; chr16:67929570-67931875 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    12
  • cDNA Data
    7
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031896 Ensembl Gene Model | MGI Sequence Detail 1860 C57BL/6J ±  kb
transcript ENSMUST00000034368 Ensembl | MGI Sequence Detail 879 Not Applicable  
polypeptide ENSMUSP00000034368 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 11
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 3
  • Earliest
    J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
  • Latest
    J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory