Ctrl
Gene Detail

Symbol Name ID

Ctrl chymotrypsin-like MGI:88558

Synonyms

0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:105931994-105933862 bp, - strand From NCBI annotation of GRCm38   1869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Ctrl

Human homologs

Human Homolog		CTRL, chymotrypsin-like
NCBI Gene ID		1506
neXtProt AC		NX_P40313
Human Synonyms		CTRL1
Human Chr (Location)		16q22.1; chr16:67929570-67931875 (-)  GRCh38

Alleles and phenotypes

Incidental mutations (data from Mutagenetix , APF )
 

Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	proteolysis
Function	hydrolase activity, peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (24)    Tissues (11)    Images (13)
Theiler Stages: 14, 22, 23, 28

Assay Type	Results
RNA in situ	13
RT-PCR	11

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031896 (Evidence)
Entrez Gene	109660 (Evidence)
NIA Mouse Gene Index	U030188
Consensus CDS Project	CCDS22620.1
International Mouse Knockout Project Status	Ctrl

Sequences

Length	Strain/Species
genomic	109660	NCBI Gene Model | MGI Sequence Detail	1869	C57BL/6J
transcript	NM_023182	RefSeq | MGI Sequence Detail	919	Not Specified
polypeptide	NP_075671	RefSeq | MGI Sequence Detail	264	Not Specified

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(51 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000006021	chymotrypsin-like protease CTRL-1

References

(Earliest) J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
(Latest) J:174611 Azhar M, et al., Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn. 2011 Jul 20;
All references(32)

Other accession IDs

MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731