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Ctrl Gene Detail
Summary
  • Symbol
    Ctrl
  • Name
    chymotrypsin-like
  • Synonyms
    0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88558
    NCBI Gene: 109660
  • Gene Overview
    MyGene.info: CTRL
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:105932003-105933862 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1860 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CTRL, chymotrypsin like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTRL, chymotrypsin like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTRL1
  • Links
    NCBI Gene ID: 1506
    neXtProt AC: NX_P40313
    UniProt: P40313

  • Chr Location
    16q22.1; chr16:67929570-67931875 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    12
  • cDNA Data
    7
  • Literature Summary
    6
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000062063 VEGA Gene Model | MGI Sequence Detail 1860 C57BL/6J ±  kb
transcript OTTMUST00000151534 VEGA | MGI Sequence Detail 879 Not Applicable  
polypeptide OTTMUSP00000078585 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 11
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 3
  • Earliest
    J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
  • Latest
    J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/11/2018
MGI 6.12 		The Jackson Laboratory