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Ctrl Gene Detail
Summary
  • Symbol
    Ctrl
  • Name
    chymotrypsin-like
  • Synonyms
    0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88558
    NCBI Gene: 109660
  • Gene Overview
    MyGene.info: CTRL
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105932003-105933862 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88558
protein coding gene Chr8:105931994-105933862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034067
protein coding gene Chr8:108255738-108257606 (-)
A/J MGP_AJ_G0034048
protein coding gene Chr8:103930029-103931897 (-)
AKR/J MGP_AKRJ_G0033974
protein coding gene Chr8:106929759-106931627 (-)
BALB/cJ MGP_BALBcJ_G0034041
protein coding gene Chr8:104112564-104114432 (-)
C3H/HeJ MGP_C3HHeJ_G0033753
protein coding gene Chr8:107672563-107674431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034561
protein coding gene Chr8:112228737-112230605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031503
protein coding gene Chr8:97062934-97064804 (-)
CAST/EiJ MGP_CASTEiJ_G0033079
protein coding gene Chr8:107192019-107193887 (-)
CBA/J MGP_CBAJ_G0033726
protein coding gene Chr8:115834349-115836217 (-)
DBA/2J MGP_DBA2J_G0033881
protein coding gene Chr8:103273273-103275141 (-)
FVB/NJ MGP_FVBNJ_G0033826
protein coding gene Chr8:102204681-102206549 (-)
LP/J MGP_LPJ_G0033972
protein coding gene Chr8:108471826-108473694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033870
protein coding gene Chr8:119025379-119027247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034579
protein coding gene Chr8:106897629-106899497 (-)
PWK/PhJ MGP_PWKPhJ_G0032780
protein coding gene Chr8:102676076-102677944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032621
protein coding gene Chr8:105589647-105591524 (-)
WSB/EiJ MGP_WSBEiJ_G0033195
protein coding gene Chr8:107584224-107586092 (-)



Homology
more
  • Human Ortholog
    CTRL, chymotrypsin like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTRL, chymotrypsin like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRL1
  • Links
    NCBI Gene ID: 1506
    neXtProt AC: NX_P40313
    UniProt: P40313

  • Chr Location
    16q22.1; chr16:67929570-67931875 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit mice exhibit reduced intrapancreatic chymotrypsin activation but normal response to induced pancreatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031896 Ensembl Gene Model | MGI Sequence Detail 1860 C57BL/6J ±  kb
    transcript ENSMUST00000034368 Ensembl | MGI Sequence Detail 879 Not Applicable  
    polypeptide ENSMUSP00000034368 Ensembl | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 1
    • Earliest
      J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
    • Latest
      J:294035 Mosztbacher D, et al., Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice. Sci Rep. 2020 Jul 16;10(1):11731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/06/2021
    MGI 6.16
    The Jackson Laboratory