Ctrl
Gene Detail

Symbol

Name
ID

Ctrl
chymotrypsin-like
MGI:88558

Synonyms

0910001G08Rik, 1810004D15Rik, chymopasin, Ctra1, Ctra-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:105931994-105933862 bp, - strand From NCBI annotation of GRCm38   1869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Ctrl

Human
homologs

Human Homolog		CTRL, chymotrypsin-like
NCBI Gene ID		1506
neXtProt AC		NX_P40313
Human Synonyms		CTRL1
Human Chr (Location)		16q22.1; chr16:67929570-67931875 (-)  GRCh38

Mutations,
alleles, and
phenotypes

Incidental mutations (data from Mutagenetix , APF )
 

Four alleles of this locus were identified. The a allele in most laboratory strains and M.m. molossinus; the c allele in IS/Cam and M. castaneus lines; the d allele in SEG/1 and SPE/Pas. The b (presumed null) allele is found in PWD/Ph and PWK/Ph.

 

Interactions

Ctrl interacts with 7 markers (Mir150, Mir706, Mir883b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (4 annotations)

Process	proteolysis
Function	peptidase activity, serine-type peptidase activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (24)    Tissues (12)    Images (13)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	13
RT-PCR	11

cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(9) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000031896 (Evidence)
Entrez Gene	109660 (Evidence)
NIA Mouse Gene Index	U030188
Consensus CDS Project	CCDS22620.1
International Mouse Knockout Project Status	Ctrl

Sequences

Length	Strain/Species
genomic	109660	NCBI Gene Model | MGI Sequence Detail	1869	C57BL/6J
transcript	NM_023182	RefSeq | MGI Sequence Detail	919	Not Specified
polypeptide	NP_075671	RefSeq | MGI Sequence Detail	264	Not Specified

All sequences(26) RefSeq(2) UniProt(8)

Polymorphisms

SNPs within 2kb(51 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000006021	chymotrypsin-like protease CTRL-1

References

(Earliest) J:1547 von Deimling OH, et al., Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991 Dec;29(11-12):545-57
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(31)

Other
accession IDs

MGD-MRK-2241, MGD-MRK-2242, MGI:1913502, MGI:1915660, MGI:2142731